Role of Nitric Oxide in the Convulsions Following the Coadministration of Enoxacin With Fenbufen in Mice
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概要
- 論文の詳細を見る
Effects of nitric oxide (NO) synthase inhibitors on the enoxacin-induced convulsions were examined in mice pretreated with fenbufen. 7-Nitroindazole markedly suppressed the incidence of convulsions, whereas L-arginine did not modify the convulsions at all. The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine. Brain NO synthase activity was significantly raised at 30 min after enoxacin when combined with fenbufen. The increased NO synthase activity was found to be suppressed by the pretreatment of 7-nitroindazole. These findings suggest that endogenous NO may be involved as a proconvulsant substance in the development of enoxacin-induced convulsions in mice pretreated with fenbufen.
- 社団法人 日本薬理学会の論文
- 1998-04-01
著者
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Natsuki Reiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Masukawa Tohru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University
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Masukawa Tohru
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi K
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Kunio
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Masukawa Tohru
Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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MASUKAWA Tohru
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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