Comparison of Contamination Levels on the Exterior Surfaces of Vials Containing Platinum Anticancer Drugs in Japan
スポンサーリンク
概要
- 論文の詳細を見る
Contamination of the external surface of anticancer drug vials supplied to hospital pharmacies has been recognized as a potential health hazard. The aim of this study was to investigate the levels of contamination on the exterior surface of vials containing platinum anticancer drugs in Japan. Platinum contamination on the exterior surface of vials containing cisplatin or carboplatin was examined using products commercially available in Japan. Cisplatin vials from 42 batches (2 drug contents, 10 products and 5 manufacturers) and carboplatin vials from 28 batches (3 drug contents, 7 products and 3 manufacturers) were used. Five vials were randomly sampled from each batch. Exterior contamination levels of 0.070–144 ng/vial as cisplatin and 0.21–1630 ng/vial as carboplatin were detected. Significant differences in the levels of contamination among the batch numbers were observed in 6 of 10 cisplatin products and 6 of 7 carboplatin products. Significant differences in the levels of contamination were observed in 3 cisplatin products with different contents of drug within the vials and 1 carboplatin product with different contents of drug within the vials. Significant differences in the contamination levels among the cisplatin manufacturers but not carboplatin manufacturers were observed. The degree of contamination of the carboplatin products was significantly higher than that of the cisplatin products. In conclusion, external contamination was confirmed in all cisplatin and carboplatin vials tested. The degree of contamination was different among different batch numbers, drug contents, manufacturers, and platinum anticancer drug.
著者
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NAITO Takafumi
Department of Clinical Pharmacy, Oita Medical University
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Nakanishi Kunio
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Kawakami Junichi
Department Of Hospital Pharmacy Hamamatsu University School Of Medicine
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Suzuki Naoya
Department Of Mechanical Engineering Faculty Of Science And Engineering Kinki University
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Takada Akira
Department Of Internal Medicine Kanazawa Medical University
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Nakanishi Kunio
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University
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Osawa Takashi
Department of Hospital Pharmacy, School of Medicine, Hamamatsu University
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Goto Toshiya
Department of Pharmacy, Iwata City Hospital
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Nakamichi Hidenori
Department of Pharmacy, Seirei Hamamatsu General Hospital
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Onuki Yoshiko
Department of Pharmacy, Seirei Hamamatsu General Hospital
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Imai Kimie
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University
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Takada Akira
Department of Pharmacy, Iwata City Hospital
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Suzuki Naoya
Department of Hospital Pharmacy, School of Medicine, Hamamatsu University
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Naito Takafumi
Department of Hospital Pharmacy, School of Medicine, Hamamatsu University
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Kawakami Junichi
Department of Hospital Pharmacy, School of Medicine, Hamamatsu University
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