HEPATIC TRIMETHADIONE-OXIDIZING CAPACITY REMAINS NORMAL IN PATIENTS WITH EXTRAHEPATIC CHOLELITHIASIS
スポンサーリンク
概要
- 論文の詳細を見る
In the present study, using trimethadione (TMO) as an indicator substrate, we estimated pre- and post-operative differences in hepatic drug-oxidizing capacity in patients with extrahepatic cholelithiasis. Only total and direct bilirubin values were significantly higher in preoperative patients than in the controls. After operative procedures, those parameters did not show significant differences from corresponding control values. The serum dimethadione (DMO)/TMO ratios estimated 4 h after administration of 4 mg/kg of TMO. Neither pre- nor post-operative serum DMO/TMO ratios were significantly different from those in the controls. These results suggest that the hepatic drug-oxidizing capacity in patients with extrahepatic cholelithiasis remains unchanged even though the bilirubin level deviated from normal.
- 公益社団法人日本薬学会の論文
著者
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ISHIKAWA Akio
Department of Chemical System Engineering, The University of Tokyo
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Ishikawa Akio
筑波大学
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TANAKA EINOSUKE
Department of Legal Medicine, Institute of Community Medicine
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MISAWA SHOGO
Department of Legal Medicine, Institute of Community Medicine
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Ono Atsushi
Toxicogenomics Project National Institute Of Biomedical Innovation:national Institute Of Health Scie
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Ono Atsushi
Biological Safety Research Center National Institute Of Health Science
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Misawa S
Inst.of Commun.med
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Misawa Shogo
Department Of Legal Medicine Institute Of Community Medicine University Of Tsukuba
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Okamura Takao
Institute Of Community Medicine:institute Of Clinical Medicine University Of Tsukuba:tsukuba Gakuen
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Okamura Takao
Department Of Thoracic-cardiovascular Surgery Juntendo University School Of Medicine Tokyo Japan
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Ishikawa Akio
Institute Of Clinical Medicine University Of Tsukuba
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ONO Atsushi
Department of Neurosurgery, Yokohama City University School of Medicine
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Ishikawa Akio
Inst.of Clin.med. Tsukuba Univ.
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Ishikawa Akio
Department Of Applied Physics Nagoya University:department Of Food And Nutrition Faculty Of Domestic
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Takabatake E
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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TAKADA AKIRA
Department of Legal Medicine, Department of Surgery, University of Tsukuba
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Takada Akira
Department Of Legal Medicine Department Of Surgery University Of Tsukuba:tsukuba Gakuen Hospital
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Tanaka Einosuke
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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Takada Akira
Department Of Internal Medicine Kanazawa Medical University
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Ono Atsushi
Department Of Neurosurgery Yokohama City University School Of Medicine
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TAKADA Akira
Department of Applied Chemistry, Faculty of Science and Technology, Keio University
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