THE OPTIMAL FLOW RATE DURING REPERFUSION AFTER HYPOTHERMIC ISCHEMIC ARREST
スポンサーリンク
概要
- 論文の詳細を見る
This experiment was designed to determine the optimal flow rate during early reperfusion after ischemic arrest for one hour at 28℃ of myocardial temperature, assessed by cardiac function, biochemistry and fine structure of the left ventricle. Under cardiopulmonary bypass (CPB) at a flow rate of 80 ml/kg/min, the ascending aorta was clamped for one hour at 28℃ of myocardial temperature in 19 mongrel dogs. After the aorta was declamped, the perfusion pressure was maintained at 50 mmHg and dogs were divided into 3 groups by flow rate of 50 (Group A), 80 (Group B) and 150 ml/kg/min (Group C) for 15 min of reperfusion. The left ventricular function was measured and calculated before the institution of CPB and 30 and 60 min after the declamping of the aorta. Myocardial isoenzymes (m-GOT, MB-CPK) in the coronary sinus venous blood were measured. Myocardial adenosine triphosphate (ATP), creatine phosphate (CP) and water content were measured by the samples of the epicardial and endocardial layers of the left ventricle and the ventricular septum at the end of experiment. The subendocardium of the left ventricle was examined by electron microscopy. Mortality rates were 1/6 (16.7%) in Group A, 2/7 (28.6%) in Group B and 4/6 (66.7%) in Group C. The myocardial water content was the lowest, and ATP was significantly higher in Group A compared to others. Left ventricular endodiastolic pressure was the lowest and the ultrastructure was well maintained in Group A. These data suggest that a high flow rate is detrimental to myocardial recovery during early reperfusion, and the optimal flow rate during early reperfusion after ischemic arrest (60 min, 28) appears to be 50 ml/kg/min.
- 社団法人日本循環器学会の論文
- 1982-05-20
著者
-
Sunamori Makoto
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
-
Sunamori Makoto
Department Of Cardiothoracic Surgery Graduate School Of Medicine Tokyo Medical And Dental University
-
Suzuki Akio
Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and Dental University
-
AMANO JUN
Department of Cardiovascular Surgery, Tokyo Medical and Dental University
-
Suzuki Akio
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
-
Okumura Takao
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
-
Okamura Takao
Department Of Thoracic-cardiovascular Surgery Juntendo University School Of Medicine Tokyo Japan
-
Amano Jun
Department Of Cardio-thoracic Surgery Juntendo Univ. School Of Med. Tokyo Med.& Dent- Univ.
-
KAMEDA TAKAAKI
Department of Cardio-Thoracic Sutgery, Juntendo University, School of Medicine
-
Kameda Takaaki
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
-
Suzuki Akio
Department Of Electrical Engineering And Electronics College Of Engineering Osaka Sangyo University
-
Suzuki Akio
Department Of Thoracic Surgery And Cardiology Juntendo University School Of Medicine Tokyo
-
Suzuki Akio
Department Of Biological Science Faculty Of Science Kumamoto University
-
Suzuki Akio
Department Of Thoracic Cardiovascular Surgery Juntendo University
-
Suzuki Akio
Department Of Biological Science Faculty Of Science Graduate School Of Science And Technology Kumamo
-
Suzuki Akio
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
関連論文
- THE EFFECTS OF CARDIOPULMONARY BYPASS ON HUMAN ATRIAL NATRIURETIC PEPTIDE (hANP) : Atrial Natriuretic Polypeptide (II) : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE STUDY OF HYPERTROPHIED RAT HEART : 1. THE NEW METHOD TO MAKE HYPERTROPHIED RAT HEART : Hemodynamics, Cardiac Function (IV) : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- Immunocytochemical Analysis of the AtheroscLerotic lesion : 54th Annual Scientific Session of the Japanese Circulation Society
- 5 Autologous Mononuclear Cell Implantation Therapy for Critical Digit Ischemia in Patients with Connective Tissue Diseases(Regenerative Therapy for Peripheral Artery Disease,Symposium 12 (SY-12) (I),The 73rd Annual Scientific Meeting of The Japanese Circu
- -240-DIGITAL SUBTRACTION LEFT VENTRICULOGRAPHY BY INJECTING CONTRAST MEDIUM TO THE RIGHT PULMONARY ARTERY : PTCA, CABG : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Percutaneous Transluminal Coronary Angioplasty for Elderly Patients : PANEL DISCUSSION ON PROBLEMS IN THE TREATMENT OF CARDIOVASCULAR DISEASES IN THE ELDERLY : 51th Annual Scientific Session of the Japanese Circulation Society
- GERMLINE MUTATIONS OF THE APC GENE IN TWO JAPANESE ADENOMATOUS POLYPOSIS PATIENTS
- PJ-689 Painless Acute Aortic Dissection-Diagnostic, Prognostic, and Clinical Implications(Peripheral circulation/Vascular disease-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Complete Pleuropneumonectomy for Non-Small Cell Lung Cancer Complicated with Chronic Bacterial Empyema and Cavitary Pulmonary Tuberculosis
- Heart failure in the dog induced by rapid ventricular pacing using a newly designed cardiac pacemaker, MCMS-0102
- OE-137 Pivotal Roles of Inflammatory Factors in Arteriosclerosis and its Specific Regulation(Infection/Inflammation/Immunity-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- IS023 Antisense Proliferating-cell Nuclear Antigen Oligonucleotide Attenuates Cardiac Allograft Arteriopathy
- Successful Surgical Treatment for Acute Aortic Dissection in Pregnancy with Marfan's Syndrome
- Update of Surgical Treatment for PAD(An Update on the Contemporary Management of Peripheral Arterial Disease, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Reversible Optical Effects in Parylene-Coated Amorphous Ga-Se-S Films
- Fatal Acute Pancreatitis with Cystic Formation in Reactive Systemic AA Amyloidosis Secondary to Rheumatoid Arthritis
- Abdominal Fat Aspiration Biopsy and Genotyping of Serum Amyloid A Contribute to Early Diagnosis of Reactive AA Amyloidosis Secondary to Rheumatoid Arthritis
- Granular Cell Tumor of the Mediastinum
- TREATMENT OF LEFT VENTRICULAR FAILURE : COMBINED USE OF PHARMACOLOGICAL AGENTS WITH IABP : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Heart Failure
- STUDIES ON THE SIGNIFICANCE OF SERUM MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE ACTIVITY FOLLOWING ISCHEMIC CARDIAC ARREST
- RAPID PROGRESSION OF CORONARY ARTERY DISEASE : COMPARISON OF CINEANGIOGRAPHIC AND NECROPSY FINDINGS IN THE SURGICAL PATIENT : Ichemic Heart Disease (I) : 46th Annual Scientific Meeting, Japanese Circulation Society
- THE OPTIMAL FLOW RATE DURING REPERFUSION AFTER HYPOTHERMIC ISCHEMIC ARREST
- OPTIMAL FLOW RATE DURING REPERFUSION AFTER CARDIOPLEGIA : Cardiovascular surgery : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- PROTECTIVE EFFECT OF NIFEDIPINE IN THE REPERFUSED ISCHEMIC MYOCARDIUM : Cardiovascular drugs (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- STUDIES ON THE SIGNIFICANCE OF MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE ACTIVITY FOLLOWING HYPOTHERMIC CARDIOPLEGIA : Ventricular function (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- ADDITIVE PROTECTION OF APROTINN, PROTEASE INHIBITOR TO COLD CARDIOPLEGIA FROM ISCHEMIC MYOCARIUM
- A Subtotal Sternectomy Successfully Reconstructed with Composix Mesh^
- Giant intraatrial septal aneurysm originating from a branch of the left coronary artery
- Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats
- Cardiac Myxoma : Its Origin and Tumor Characteristics
- Cloned Cytosine Deaminase Gene Expression of Bifidobacterium longum and Application to Enzyme/Pro-drug Therapy of Hypoxic Solid Tumors(Biochemistry & Molecular Biology)
- Stromal sarcoma of the breast with leiomyosarcomatous pattern
- The Likely Transformation of Papillary Thyroid Carcinoma into Anaplastic Carcinoma During Postoperative Radioactive Iodine-131 Therapy : Report of a Case
- Solitary Brain Metastasis from Papillary Thyroid Carcinoma in a Patient with Depression : Report of a Case
- Multiple Branchial Cleft-Like Cysts in a Female Patient with Hashimoto's Thyroiditis
- Tumor Marker Levels Elevate False-Positively in Postsurgical Breast Cancer Patients with High sGPT Levels or with Receiving Oral 5-FU or Its Derivatives
- Pulsed Laser Deposition of Transparent Conducting Indium Tin Oxide Films in Magnetic Field Perpendicular to Plume : Surfaces, Interfaces, and Films
- Large Transmittance Changes Near the Ultraviolet Region Observed on a Laminated Multilayer Structure of Ga_2O_3 and In_2O_3 Prepared by the Pulsed Laser Deposition Method
- Micro-Textured Milky ZnO:Ga Thin Films Fabricated by Pulsed Laser Deposition Using Second-Harmonic-Generation of Nd:YAG Laser
- Optical Recording in Ga and In-Doped Zinc Oxide Thin Films Grown by Radio-Frequency Magnetron Sputtering
- Large Transmittance Changes Induced in Ga-Doped ZnO Thin Films Prepared by Pulsed Laser Deposition
- Surface Flatness of Transparent Conducting ZnO:Ga Thin Films Grown by Pulsed Laser Deposition
- Transparent Conducting Al-Doped ZnO Thin Films Prepared by Pulsed Laser Deposition
- Phase-Change Optical Recording Films with AgInTe_2-Sb -Te System
- Photovoltaic Effect of Amorphous In_xSe_ Film-SnO_2 Structure : II-3: AMORPHOUS SEMICONDUCTOR PHOTOVOLTAIC DEVICES
- Photocrystallization of Amorphous Ge_xSe_ Films
- Photovoltaic Effect of Amorphous Ga_xSe_-SnO_2 Heterostructure
- 105 Basic Study on Forel-H-tomy
- Novel HERG mutations in long QT syndrome in Japan
- EFFECT OF CATECHOLAMINE ON REPERFUSED MYOCARDIUM FOLLOWING HYPOTHERMIC GLOBAL ISCHEMIA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Extracorporeal Circulation
- Surgical Treatment of Annulo-aortic Ectasia : SYMPOSIUM ON CLINICAL PROBLEMS IN AORTIC DISEASES
- Multiple Carcinoids of the Duodenum Accompanied by Type I Familial Multiple Endocrine Neoplasia
- Briateral Synchronous Spindle Cell, Apocrine and Scirrhous Carcinoma Breast Cancer in a Case of Malignant Lymphoma
- Squamous Cell Carcinoma Arising from Thyroglossal Duct Remnants:Report of a Case and Results of Immunohistochemical Studies
- Postoperative Outcome of Insufficient Surgery for Small Differentiated Thyroid Carcinoma
- Expression of Fibroblast Growth Factor-2 and Fibroblast Growth Factor Receptor-1 in Thyroid Diseases : Difference between Neoplasms and Hyperplastic Lesions
- Development of Graves' Disease after Surgical Treatment for Thyroid Nodules : Report of Four Cases
- Development of Graves' Disease from Asymptomatic Autoimmune Thyroiditis: A Case Report
- A MORPHOMETRICAL STUDY OF MYOCARDIAL DISARRAY ASSOCIATED WITH RIGHT VENTRICULAR OUTFLOW TRACT OBSTRUCTION
- MORPHO-DYNAMIC STUDIES OF NATIVE CORONARY ARTERY AND VEIN GRAFT FOLLOWING AORTO-CORONARY PROCEDURE : AN ANGIOGRAPHIC ANALYSIS : Cardiac Surgery: Coronary Artery Disease : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- Physiological Comparison of Off-pump and On-pump Coronary Artery Bypass Grafting in Patients on Chronic Hemodialysis
- Hand circulation after radial artery harvest for coronary artery bypass grafting
- Oral Cibenzoline Reduces Postoperative Atrial Fibrillation in Coronary Artery Bypass Grafting
- Transaortic Stented Graft Implantation for Aortic Arch Aneurysm : Its Benefits and Risk
- Biventricular Pacing in a Patient With Severe Congestive Heart Failure
- Temporary and Permanent Biventricular Pacing via Left Ventricular Epicardial Leads Implanted during Primary Cardiac Surgery
- Lipopolysaccharide pretreatment attenuates myocardial ischemiareperfusion injury : a possible mechanism involving heat shock protein 70-I κ B α complex and attenuation of nuclear factor- κ B
- Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1
- Pure Clear Cell Papillary Thyroid Carcinoma with Chronic Thyroiditis : Report of a Case
- LEFT VENTRICULAR VOLUME AND SHAPE CHARACTERISTICS IN PRE- AND POST-RADIAL OPERATIVE PATIENTS WITH TETRALOGY OF FALLOT : Congential Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- Role of MDM2 Overexpression in Doxorubicin Resistance of Breast Carcinoma
- MDM2 in Breast Cancer
- ASSESSMENT OF MITRAL COMPLEX IN PATIENTS WITH ISOLATED PURE MITRAL STENOSIS A NEW METHOD FOR QUANTITATIVE ANALYSIS OF SUBVALVULAR INVOVLVMENT : Cardiac Performance : IIIrd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Soc
- Graft Arterial Disease (GAD) : A Model for Investigating Inflammation and T Cell-Mediated Immunity in Coronary Arteriosclerosis
- Comparison of various balance systems for energy conservation in a vertically articulated manipulator with three joints
- EXPERIMENTAL STUDIES ON VEIN GRAFT ATHEROSCLEROSIS (I) HISTOCHEMICAL STUDIES USING MONOLONAL ANTIBODIES FOR SMOOTH MUSCLE CELLS AND MACROPHAGES
- Multiple Thymoma with Myasthenia Gravis : Report of a Case
- Mediastinal Neurilemmoma Complicated With Spinal Subarachnoid Hemorrhage
- Significance of Serum Atrial and Brain Natriuretic Peptide Release After Coronary Artery Bypass Grafting
- Intrusion of UHP metamorphic rocks into the upper crust of Kyrgyzian Tien-Shan : P-T path and metamorphic age of the Makbal Complex
- Endoscopic Radial Artery Harvesting : Our Initial Experience and Results of the First 25 Patients
- Direct Observation of the Filamentary Path Formed in In-Te System
- Rupture of a Large Cell Neuroendocrine Carcinoma, Causing Early Local Recurrence
- Blastopore formation and dorsal mesoderm induction are independent events in early Cynops embryogenesis
- Immunohistochemical Expression of bcl-2 Protein in Squamous Cell Carcinoma and Basaloid Carcinoma of the Esophagus
- Painless Acute Aortic Dissection : Diagnostic, Prognostic and Clinical Implications
- Expression of nitric oxide and inducible nitric oxide synthase in acute renal allograft rejection in the rat
- Comparative study of sequential expression of the organizer-related genes in normal Cynops pyrrhogaster embryos and mesodermalized ectoderm
- The fundamental properties of Homer 1 in association with cardiac ryanodine receptor in mouse heart
- Application of Microtiter Plate Assay to Evaluate Inhibitory Effects of Various Compounds on Nine Cytochrome P450 Isoforms and to Estimate their Inhibition Patterns
- Photovoltaic Effect Observed on the Construction of Metal-Amorphous ln_xSe_ Thin Film-SnO_2 System
- Photovoltaic Effect of Ge_xSe_ Thin Film Schottky Diode
- Photovoltaic Effect of Amorphous In_xSe_-SnO_2 Heterostructure
- Electrical and Optical Properties of Ge_xSe_ Amorphous Thin Films
- Photovoltaic Effect of Ge_xSe_ -Se - SnO_2 Heterostructure
- PROTECTIVE EFFECT OF LIDOCAINE IN REPERFUSED ISCHEMIC MYOCARDIUM : Evaluation by Hemodynamic and Biochemical Study
- Effect of the Potassium-Channel Opener Nicorandil as an Adjunct to Cardioplegia on Myocardial Preservation in Isolated Rabbit Hearts
- RELATIONSHIP BETWEEN HEMODYNAMICS DURING IMMEDIATE REPERFUSION AND MITOCHONDRIAL FUNCTIONAL RECOVERY IN THE ISCHEMIC MYOCARDIUM
- EFFECT OF MAGNESIUM IN CARDIOPLEGIC SOLUTION UPON HYPOTHERMIC ISCHEMIC MYOCARDIAL MITOCHONDRIA
- Good Syndrome with Thymic Adenosquamous Carcinoma : Report of a Case