Immunocytochemical Analysis of the AtheroscLerotic lesion : 54th Annual Scientific Session of the Japanese Circulation Society

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概要

• 論文の詳細を見る

• We have performed immunocytochemical investigations on the distribution of various cell types and proliferating cells in human atherosclerotic lesions. Studies include fibrocellular tissue response following percutaneous transluminal coronary angioplasty (PTCA) or aortocoronary (A-C) bypass operation using monoclonal antibodies specific to smooth muscle cells, macrophages. endothelial cells, lymphocytes and proliferating cell nuclear antigen (PCNA). All studies were performed on methanol-Carnoy's-fixed. paraffin-embedded tissues. The cellular composition of the following three types of raised lesions were analyzed: 1) fibro-fatty lesions composed almost exclusively of macrophages: 2) fibrous lesions predominantly composed of smooth muscle cells; 3) advanced plaques characterized by complex layers of smooth muscle cells and macrophages with considerable variation from region to region. Also noted were foci of medial and even intimal vascularization subjacent to the more advanced plaques. Cells encountered within the fibrous intimal thickening in the vein graft or fibrocellular tissue reponse following PTCA were predominantly smooth muscle cells in origin. Some cells were PCNA-positive. These studies demonstrate the application of monoclonal antibody technology to the study of the cellular composition and cell kinetics of human atherosclerotic lesions.

• 社団法人日本循環器学会の論文
• 1991-10-20

著者

• UEDA Makiko

  Department of Pathology, Osaka City University Graduate School of Medicine

• Ueda Makiko

  Department Of Pathology Osaka City University Graduate School Of Medicine

• Ueda Makiko

  First Department Of Pathology Osaka City University Medical School

• TSUKADA TOYOHIRO

  Department of Internal Medicine (2), Sanraku Hospltal

• KUBOTA AKIYOSHI

  Department of Internal Medicine (2), Sanraku Hospltal

• AMANO JUN

  Department of Cardiovascular Surgery, Tokyo Medical and Dental University

• SHIMOKADO KENTARO

  Research Institute of the National Cardiovascular Center

• NUMANO FUJIO

  Department of Internal Medicine (3), Tokyo Medical and Dental University

• Numano Fujie

  The Their Department Of Internal Medicine Tokyo Medical And Dentao University

• Kubota Akiyoshi

  Department Of Internal Medicine (2) Sanraku Hospltal

• Kubota Akiyoshi

  三楽病院

• Numano Fujio

  Third Department Of Internal Medicine Tokyo Medical And Dental University

• Ueda Makiko

  Department Of Pathology Graduate School Of Medicine Osaka City University

• Numano Fujio

  Department Of Cardiovascular Medicine Tokyo Medical And Dental University

• Numano Fujio

  Department Of Internal Medicne Tokyo Medical And Dental University.

• Amano Jun

  Department Of Cardio-thoracic Surgery Juntendo Univ. School Of Med. Tokyo Med.& Dent- Univ.

• NUMANO FUJIO

  Depertment of Internal Medicine

• Tsukada Toyohiro

  Second Department Of Internal Medicine Sanraku Hospital

• Tsukada Toyohiro

  Department Of Internal Medicine (2) Sanraku Hospital

• Amano Jun

  Department Of Cardiovascular Surgery Tokyo Medical And Dental University

• Numano Fujio

  Institute For Cardiovascular Diseases Tokyo Medical And Dental University

• Shimokado Kentaro

  Department Of Internal Medicne Tokyo Medical And Dental University.

• Numano Fujio

  Department Of Internal Medicine (3) Tokyo Medical And Dental University

• Tsukada Toyohiro

  Department Of Internal Medicine (2) Sanraku Hospltal

• Numano Fujie

  Department Of Internal Medicine (3) Tokyo Medical And Dental University

• Numano Fujio

  The Third Division Department Of Internal Medicine Tokyo Medical And Dental Univ.

• UEDA MAKIKO

  First Department of Pathology, Osaka City University Medical School

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