Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients
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概要
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Background: S100A8/A9 complex (S100A8/A9) is expressed in activated human neutrophils and macrophages. Enhanced expression of S100A8/A9 in atherosclerotic plaque of patients with unstable angina pectoris (UAP) has been demonstrated, but its profile in acute myocardial infarction (AMI) has not been clarified. Methods and Results: Serum S100A8/A9 levels were serially measured in patients with AMI (n=55) and UAP (n=16) during the acute period. The expression of S100A8/A9 was examined immunohistochemically in the infarcted myocardium of 7 autopsied patients with AMI. Serum S100A8/A9 levels on the 1st day were 1,118±115 (SE) ng/ml in AMI patients as compared with 787±147 ng/ml in UAP patients. On days 3-5, serum S100A8/A9 levels in AMI patients reached a peak value and were significantly higher than the values in UAP patients (1,690±144 ng/ml vs 844±100 ng/ml; P<0.0001). In AMI patients, peak S100A8/A9 levels positively correlated with peak white blood cell and neutrophil counts, and peak creatine kinase-MB and peak C-reactive protein levels. Double immunostaining revealed that S100A8/A9 was specifically expressed in neutrophils and macrophages infiltrating the infarcted myocardium. Conclusions: S100A8/A9 is implicated in the pathophysiology of AMI and may be an additional biomarker of the local inflammatory response following AMI.
著者
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Sato Akira
Department of Cardiology, Yokosuka Kyosai Hospital
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Hiroe Michiaki
Department of Nephrology and Cardiology, International Medical Center of Japan
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FUJITA Masatoshi
Human Health Sciences, Graduate School of Medicine, Kyoto University
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Kitaura Yasushi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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IKURA Yoshihiro
Department of Pathology, Osaka City University Graduate School of Medicine
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UEDA Makiko
Department of Pathology, Osaka City University Graduate School of Medicine
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NARUKO Takahiko
Department of Cardiology, Osaka City General Hospital
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Hiroe Michiaki
国立国際医療センター研究所 遺伝子診断治療開発研究部
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Otsuka Kaoru
Department of Internal Medicine III, Osaka Medical College
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Terasaki Fumio
Department of Internal Medicine III, Osaka Medical College
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Katashima Takashi
Department of Internal Medicine III, Osaka Medical College
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Murakami Shougo
Department of Internal Medicine III, Osaka Medical College
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Ikemoto Masaki
Human Health Sciences, Kyoto University Graduate School of Medicine
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