Noninvasive Detection of Cardiac Repair After Acute Myocardial Infarction in Rats by 111In Fab Fragment of Monoclonal Antibody Specific for Tenascin-C
スポンサーリンク
概要
- 論文の詳細を見る
Left ventricular (LV) remodeling after acute myocardial infarction (MI) causes heart failure, and thus it is important to evaluate cardiac repair as the early stage of LV remodeling. Tenascin-C (TNC), an extracellular matrix glycoprotein, is transiently and abundantly expressed in the heart during the early stage of tissue remodeling after MI. However, it is not expressed in healthy adult heart. This study was undertaken to develop a new noninvasive diagnostic technique to detect cardiac repair after acute MI using 111In Fab fragment of a monoclonal antibody specific for TNC. 111In-anti-TNC-Fab was injected intravenously in 13 rats at 1 (D1, n = 3), 3 (D3, n = 5), and 5 (D5, n = 5) days after producing MI and in 5 sham-operated rats (S). We performed autoradiography and dual-isotope single-photon emission computed tomography imaging (SPECT) of 111In-anti-TNC-Fab and 99mTc methoxyisobutyl isonitrile (MIBI). The radioactivity in the heart was significantly higher in D (D1, 0.45 ± 0.06% injected-dose/g; D3, 0.64 ± 0.12; D5, 0.38 ± 0.07) than S (0.27 ± 0.06, P < 0.01 versus D1 and D3, P < 0.05 versus D5). By autoradiography, higher radioactivities were observed in the infarcted area than in the noninfarcted area of MI hearts. Dual-isotope SPECT demonstrated the regional myocardial uptake of 111In-anti-TNC-Fab, which was complementary to the perfusion image. The results of the present study indicated that we can localize the infarcted region in the heart by ex vivo and in vivo imaging methods using 111In-anti-TNC-Fab, and suggested the potential usefulness of noninvasive detection of cardiac repair.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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Hiroe Michiaki
Department of Nephrology and Cardiology, International Medical Center of Japan
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Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine
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Imanaka-Yoshida Kyoko
Department of Laboratory Medicine, Mie University School of Medicine
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Hasegawa Hiroshi
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Tadokoro Hiroyuki
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Odaka Kenichi
Department of Cardiovascular Science and Medicine
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Yoshida Katsuya
Department of Cardiolvascular Science and Medicine, Chiba University Graduate School of Medicine
-
Imanaka-yoshida Kyoko
Department Of Department Of Pathology Mie University School Of Medicine
-
Odaka Kenichi
放射線医学総合研究所分子イメージング研究センター
-
Irie Toshiaki
放射線医学総合研究所分子イメージング研究センター
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Uehara Tomoya
Department of Molecular Imaging and Radiotherapy, Chiba University Graduate School of Pharmaceutical
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Arano Yasushi
Department of Molecular Imaging and Radiotherapy, Chiba University Graduate School of Pharmaceutical
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Adachi Sayaka
Department of Molecular Imaging and Radiotherapy, Chiba University Graduate School of Pharmaceutical
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Yoshida Toshimichi
Department of Pathology, Mie University School of Medicine
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Irie Toshiaki
Department of Medical Imaging, National Institute of Radiological Sciences
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Tanada Shuji
Department of Medical Imaging, National Institute of Radiological Sciences
-
Tanada Shuji
Department Of Medical Imaging National Institute Of Radiological Sciences
-
Irie Toshiaki
Department Of Medical Imaging National Institute Of Radiological Sciences
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Uehara Tomoya
Department Of Molecular Imaging And Radiotherapy Chiba University Of Pharmaceutical Sciences
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Arano Yasushi
Department Of Molecular Imaging And Radiotherapy Chiba University Of Pharmaceutical Sciences
-
Hiroe Michiaki
Department Of Cardiology International Medical Center Of Japan
-
Yoshida Toshimichi
Department Of Pathology
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Odaka Kenichi
Department Of Cardiolvascular Science And Medicine Chiba University Graduate School Of Medicine
-
Tadokoro Hiroyuki
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Yoshida Katsuya
Department Of Cardiology Kawasaki Medical School
-
Hasegawa Hiroshi
Department Of Adme And Toxicology For Screening Developmental Research Laboratories Shionogi & Co. Ltd.
-
Komuro Issei
Department Of Cardiovascular Medicine
-
Yoshida Katsuya
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
-
Imanaka-Yoshida Kyoko
Department of Pathology, Mie University School of Medicine
-
Odaka Kenichi
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Uehara Tomoya
Department of Molecular Imaging and Radiotherapy, Chiba University Graduate School of Pharmaceutical Sciences
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