Angiotensin II Type 1a Receptor Signals are Involved in the Progression of Heart Failure in MLP-Deficient Mice
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概要
- 論文の詳細を見る
Background Angiotensin II (AT) is implicated in the development of cardiac remodeling, which leads to heart failure, and pharmacological inhibition of the AT type 1 (AT_1) receptor has improved mortality and morbidity in patients of heart failure. The aim of this study was to elucidate the role of the AT_1 receptor in disease progression in muscle LIM protein (MLP)-deficient mice, which are susceptible to heart failure because of defective function of mechanosensors in cardiomyocytes. Method and Results Hearts from MLP knockout (MLPKO) mice and MLP-AT_<1a> receptor double knockout (DKO) mice were analyzed. MLPKO hearts showed marked chamber dilatation with cardiac fibrosis and reactivation of the fetal gene program. All of these changes were significantly milder in the DKO hearts. Impaired left ventricular (LV) contractility and filling were alleviated in DKO hearts. However, the impaired relaxation and downregulated expression of sarcoplasmic reticulurn calcium-ATPase 2 were unchanged in DKO hearts. Conclusions The AT_<1a> receptor is involved in progression of LV remodeling and deterioration of cardiac function in the hearts of MLPKO mice. These results suggest that blockade of the receptor is effective in preventing progression of heart failure in dilated cardiomyopathy.
- 社団法人日本循環器学会の論文
- 2007-11-20
著者
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Akazawa Hiroshi
Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine
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Komuro Issei
Department of Cardiovascular Science and Medicine, Chiba University graduate School of Medicine
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Qin Yingjie
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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YASUDA Noritaka
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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ITO Kaoru
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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KUDO Yoko
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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YAMAMOTO Rie
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Itoh Kaoru
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
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Toko Haruhiro
Department of Cardiovascular Science and Medicine
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Sano Masanori
Department of Cardiovascular Science and Medicine
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Sugaya Takeshi
Discovery Laboratory, Tanabe Seiyaku Co, Ltd
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Chien Kenneth
Cardiovascular Research Center, Massachusetts General Hospital
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Horii Taiko
Kagawa University
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Takano H
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Yamamoto Rie
Department Of Cardiovascular Science And Medicine
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Itoh Kaoru
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Akazawa H
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Akazawa Hiroshi
千葉大学 循環病態医科学
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Akazawa Hiroshi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Toko Haruhiro
千葉大学 循環病態医科学
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Toko Haruhiro
大阪医科大学 3内
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夛田 浩
群馬県立心臓血管センター
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Kudo Yoko
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Sakai Masashi
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Yamamoto Rie
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Yasuda Noritaka
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Yasuda Noritaka
Department Of Cardiovascukar Science Arid Medicine Chiba University Graduate School Of Medicine
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Chien Kenneth
Cardiovascular Research Center Massachusetts General Hospital
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Sugaya Takeshi
Discovery Laboratory Tanabe Seiyaku Co Ltd
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Hoshi Tomoya
Institute Of Clinical Medicine University Of Tsukuba
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Komuro Issei
Department Of Cardiovascular Medicine Chiba University School Of Medicine
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Sano Masanori
Department Of Biology Faculty Of Science And Engineering Konan University
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Sano Masanori
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Toukou Haruhiro
Third Division Department Of Internal Medicine Osaka Medical College
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Ito Kaoru
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine
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Toko Haruhiro
Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medecine
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Horii Taikou
Department Of Cardiovascular Surgery Hayama Heart Center
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Akazawa Hiroshi
Department Of Cardiovascular Science And Medicine Chiba University
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Akazawa Hiroshi
Department Of Cardiovascular Science And Medicine
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Toko Haruhiro
Department Of Cardiovascular Medicine Chiba University Graduate School Of Medicine
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Komuro Issei
Department Of Cardiovascular Medicine
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ITO Kaoru
Department of Anesthesiology, School of Medicine, Tokai University
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