EFFECT OF MAGNESIUM IN CARDIOPLEGIC SOLUTION UPON HYPOTHERMIC ISCHEMIC MYOCARDIAL MITOCHONDRIA
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概要
- 論文の詳細を見る
Twelve anesthetized mongrel dogs were subjected to systemic hypothermia and potassium-induced cardioplegia for 60 minutes with or without magnesium-1-aspartate. The effect of magnesium was assessed by indices of mitochondrial oxidative phosphorylation. Cardiac arrest was induced by potassium (20 mEq per liter) (6 dogs) or potassium (20 mEq per liter)-magnesium (8 mM per liter). The heart was reperfused for ten minutes following arrest. Dogs were supported by standard cardiopulmonary bypass with hypothermia at 20℃ of myocardial temperature. Mitochondria were isolated from the endocardium, the epicardium of the left ventricle and the ventricular septum. ADP : 0 ratio state 3 respiration were well maintained in both groups following 60 minutes of ischemic arrest and 10 minutes of reperfusion. Magnesium suppressed the non-phosphorylated oxygen consumption of mitochondria, therefore, respiratory control index was significantly enhanced in the group of potassium-magnesium-1-aspartate cardioplegia. These data suggest that magnesium protects functional capacity of mitochondrial phosphorylation in the myocardium from ischemia.
- 社団法人日本循環器学会の論文
- 1980-03-20
著者
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Sunamori Makoto
Department Of Cardiothoracic Surgery Graduate School Of Medicine Tokyo Medical And Dental University
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Sunamori Makoto
Department Of Thoracic And Cardiovascular Surgery Juntendo University
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Suzuki Akio
Department Of Electrical Engineering And Electronics College Of Engineering Osaka Sangyo University
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HARRISON Jr.
School of Medicine and Cardiovascular Disease, Mayo Clinic
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Harrison Jr.
School Of Medicine And Cardiovascular Disease Mayo Clinic
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Suzuki Akio
Department Of Biological Science Faculty Of Science Kumamoto University
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Suzuki Akio
Department Of Thoracic And Cardiovascular Surgery Juntendo University
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Suzuki Akio
Department Of Biological Science Faculty Of Science Graduate School Of Science And Technology Kumamo
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Suzuki Akio
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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