STUDIES ON THE SIGNIFICANCE OF SERUM MITOCHONDRIAL ASPARTATE AMINOTRANSFERASE ACTIVITY FOLLOWING ISCHEMIC CARDIAC ARREST
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概要
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Aspartate aminotransferase (EC 2.6.1.1.:AST) is known to have two isoenzymes, one associated with the cytoplasm (c-AST) and the other with the mitochondria (m-AST). We studied the relationships of m-AST activity in the coronary sinus blood to left ventricular function, coronary blood flow, water content and high-energy phosphate stores of the left ventricle following hypothermic ischemic cardiac arrest. Under cardiopulmonary bypass with hypothermia of 20℃ of myocardial temperature, 120 min of aortic occlusion was employed in 15 mongrel dogs. Left ventricular function (peak left ventricular pressure, left ventricular enddiastolic pressure, max dp/dt, cardiac index, left ventricular stroke work index), coronary blood flow, myocardial oxygen consumption, myocardial enzyme activity (m-AST, CK-MB), myocardial water content and high-energy phosphate stores (adenosine triphosphate, creatine phosphate) of the subendocardium of the left ventricle were measured. Data was obtained in the control state, and after 0, 30 and 60 min of reperfusion. Significant negative correlations were obtained between m-AST activity and peak left ventricular pressure (r = -0.81, p<0.001), max dp/dt (r = -0.83, p<0.001), cardiac product (r= -0.73, p<0.01), coronary blood flow (r = -0.59, p<0.05), adenosine triphosphate level (r = -0.72, p<0.01) and creatine phosphate level (r = -0.72, p<0.02) after 60 min of reperfusion. Significant positive correlations were obtained between m-AST activity and left ventricular end-diastolic pressure (r = 0.75, p<0.01) and water content (r = 0.78, p<0.0 1 ) after 60 min of reperfusion. These results led to the assumption that serum m-AST activity in the coronary venous blood is a useful index to evaluate the degree of myocardial injury.
- 社団法人日本循環器学会の論文
- 1982-12-20
著者
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Sunamori Makoto
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
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Sunamori Makoto
Department Of Cardiothoracic Surgery Graduate School Of Medicine Tokyo Medical And Dental University
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Suzuki Akio
Department of Thoracic and Cardiovascular Surgery, Tokyo Medical and Dental University
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AMANO JUN
Department of Cardiovascular Surgery, Tokyo Medical and Dental University
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Suzuki Akio
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
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Okumura Takao
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
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Amano Jun
Department Of Cardio-thoracic Surgery Juntendo Univ. School Of Med. Tokyo Med.& Dent- Univ.
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KAMEDA TAKAAKI
Department of Cardio-Thoracic Sutgery, Juntendo University, School of Medicine
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Kameda Takaaki
Department Of Thoracic & Cardiovascular Surgery Juntendo University School Of Medicine
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Suzuki Akio
Department Of Electrical Engineering And Electronics College Of Engineering Osaka Sangyo University
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Suzuki Akio
Department Of Thoracic Surgery And Cardiology Juntendo University School Of Medicine Tokyo
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Suzuki Akio
Department Of Biological Science Faculty Of Science Kumamoto University
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Suzuki Akio
Department Of Thoracic Cardiovascular Surgery Juntendo University
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Suzuki Akio
Department Of Biological Science Faculty Of Science Graduate School Of Science And Technology Kumamo
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Suzuki Akio
Department of Applied Chemistry, Faculty of Engineering, Yamagata University
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