Assessment of Benzydamine N-Oxidation Mediated by Flavin-Containing Monooxygenase in Different Regions of Rat Brain and Liver Using Microdialysis
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概要
- 論文の詳細を見る
N-Oxidation of benzydamine (BZY) mediated by flavin-containing monooxygenase (FMO) was evaluated by microdialysis in vivo in different regions of rat brain and liver. The probe was implanted into local regions of the brain, such as the olfactory bulb, cerebral cortex, corpus striatum, hippocampus and cerebellum, or the hepatic lobe. By perfusing BZY via the probe, BZY N-oxide was identified in the dialysate. The estimated concentrations of BZY N-oxide in extracellular fluid were almost the same as those in the olfactory bulb, hippocampus and cerebral cortex, half the concentration in the hepatic lobe; however, the concentration in the corpus striatum was lower and that in the cerebellum was higher than in the other regions. These results demonstrate that the extracellular concentration of BZY N-oxide formed in vivo was unexpectedly high in every brain region.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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YAMAGUCHI Tomohiro
Department of Surgery, Shiga University of Medical Science
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TOCHINO Yoshihiro
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University
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ISOBE Masakazu
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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TAKABATAKE Eigo
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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Isobe M
Setsunan Univ. Osaka Jpn
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Isobe M
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Faculty Of Pharmaceutical Sciences University Of Setsunan
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KAWAJI AKIKO
Department of Micro System Engineering, Graduate School of Engineering, Nagoya University
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Takabatake E
Setsunan Univ. Osaka Jpn
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Takabatake Eigo
Department Of Pharmaceutical Sciences Institute Of Public Health
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Yamaguchi Tomohiro
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Yamaguchi Tomohiro
Department Of Applied Chemistry Faculty Of Engineering Kumamoto University
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Kawaji A
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Kawaji Akiko
Department Of Micro System Engineering Graduate School Of Engineering Nagoya University
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Kawaji Akiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Laboratory Of Drug Metabolism Ε-toxicology Department Of Hygienic Chemistry Tokyo College Of Pharmac
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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Tochino Y
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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TOCHINO Yoshihiro
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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