Brain glutathione and the anti-hypoxic effect of glutathione depletors in mice.
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概要
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The anti-hypoxic effect (assessed by a standard hypoxia survival test) 3 hr after 2-cyclohexene-1-one (CHX) was completely abolished by injections of L-cysteine after CHX. Under these conditions, brain GSH was depleted to about 50% of the control level in CHX-treated mice and recovered to about 80% of control level following L-cysteine post-treatment. However, D-cysteine could not cause such effects. Intracerebroventricular injection of CHX, which caused a selective depletion of brain GSH, produced an anti-hypoxic effect. Thus, the anti-hypoxic effect may be related to the decrease of brain GSH levels.
- 公益社団法人 日本薬理学会の論文
著者
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TOCHINO Yoshihiro
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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MASUKAWA Tohru
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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SAI Midori
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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