Involvement of Blood Glucose in the Dimethylthiourea-Induced Protection against Alloxan-Induced Diabetes.
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概要
- 論文の詳細を見る
Dimethylthiourea (DMTU, 4.0 mmol/kg) injected into mice 30 min prior to alloxan injection markedly protected mice against the diabetogenic actions of 75 mg/kg alloxan. At 30 min after the above dose of DMTU alone (no alloxan), there was a marked rise in blood glucose. Mannoheptulose, an antagonist of glucose action at pancreatic β-cells, when given 24 min after DMTU and 6 min before alloxan, eliminated the DMTU-induced protection. The protection was also removed in the fasted mice in which DMTU did not cause hyperglycemia. These results indicate that DMTU protected mice from alloxan-induced diabetes by the indirect mechanism of producing hyperglycemia at the time of alloxan injection.
- 公益社団法人 日本薬理学会の論文
著者
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Nakanishi Kunio
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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MASUKAWA Tohru
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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