Circadian Variation in Enoxacin : Induced Convulsions in Mice Coadministered with Fenbufen
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概要
- 論文の詳細を見る
Susceptibility to enoxacin (80 mg/kg, p.o.)-induced convulsions was examined in mice coadministered with fenbufen (100 mg/kg, p.o.) over 24 hr at 3-hr intervals (light 7:00-19:00 hr). There was a marked circadian variation in the incidence of clonic and tonic convulsions and mortality. The susceptibility to enoxacin was higher around 15:00-18:00 hr and lower around 3:00-9:00 hr; the 50% clonic convulsive dose (CD<SUB>50</SUB>) at 9:00 and 15:00 hr was 95.0 and 56.5 mg/kg, respectively, its ratio being 1.64. Under these conditions, brain enoxacin level at 15:00 hr was increased 2.43-fold over that at 9:00 hr 30 min after enoxacin administration. Thus, the change of brain enoxacin may contribute to one of the causes of the above circadian variation.
- 社団法人 日本薬理学会の論文
- 1997-02-01
著者
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Masukawa Tohru
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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Nakanishi Kunio
Department Of Clinical Biochemistry Faculty Of Pharmaceutical Sciences Setsunan University
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MASUKAWA Tohru
Department of Biology and Clinical Physiology, Faculty of Pharmaceutical Sciences, Setsunan University
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