STUDIES ON METABOLISM AND TOXICITY OF STYRENE. I. BIOTRANSFORMATION OF STYRENE TO STYRENE GLYCOL VIA STYRENE OXIDE BY RAT LIVER MICROSOMES

スポンサーリンク

概要

• 論文の詳細を見る

• Biotransformation of styrene (ethenylbenzene) into styrene glycol (1-phenyl-1,2-ethanediol) via styrene oxide (phenyloxirane), a mutagen and skin carcinogen, by rat liver microsomes in the presence of an NADPH-generating system has been investigated. Both metabolites were identified by gas-chromatography-mass spectroscopy. In the microsomal system, styrene oxide appeared only after a brief incubation and disapeared thereafter in spite of the continued formation of styrene glycol. This phenomenon was rationally interpreted on the basis of previously obtained evidence that during aerobic incubations, NADPH-dependent microsomal lipid peroxidation decreased P-450 activities selectively to a remarkable extent compared with epoxide hydratase activities. Addition of 3,3,3-trichloropropene oxide, a potent epoxide hydratase inhibitor, to the incubation medium prolonged the biological half-life of styrene oxide significantly, indicating one of major factors determining the biological level of the mutagen to be the relative ratio of these enzyme activities.

• 公益社団法人日本薬学会の論文

著者

• ISOBE Masakazu

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University

• WATABE TADASHI

  Laboratory of Drug Metabolism and Toxicology, Department of Hygienic Chemistry, Tokyo College of Pha

• TAKABATAKE Eigo

  Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University

• ISOBE MASAKAZU

  Laboratory of Drug Metabolism and Toxicology, Department of Hygienic Chemistry, Tokyo College of Pha

• Isobe M

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

• Isobe Masakazu

  Laboratory Of Drug Metabolism & Toxicology Department Of Hygienic Chemistry Tokyo College Of Pha

• Isobe Masakazu

  Faculty Of Pharmaceutical Sciences University Of Setsunan

• Watabe Tadashi

  Laboratory Of Drug Metabolism & Toxicology Department Of Hygienic Chemistry Tokyo College Of Pha

• Takabatake E

  Setsunan Univ. Osaka Jpn

• Yoshikawa Kunie

  Department Of Microbiology National Institute Of Hygienic Sciences

• Takabatake Eigo

  Department Of Pharmaceutical Sciences Institute Of Public Health

• Watabe Tadashi

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University:laboratory Of Drug M

• Takabatake E

  Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University

• Isobe Masakazu

  Laboratory Of Drug Metabolism Ε-toxicology Department Of Hygienic Chemistry Tokyo College Of Pharmac

• Takabatake E

  Inst.of Commun.med

• Watabe Tadashi

  Laboratory Of Drug Metabolism And Toxicology Department Of Hygienic Chemistry Tokyo College Of Pharm

• Watabe Tadashi

  Laboratory Of Drug Metabolism & Toxicology Department Of Hygienic Chemistry Tokyo College Of Pha

関連論文

• Partial Purification and Substrate Specificity of Flavin-Containing Monooxygenase from Rat Brain Microsomes
• Determination of Flavin-Containing Monooxygenase Activity in Rat Brain Microsomes with Benzydamine N-Oxidation
• TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
• THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
• Purification and Characterization of Hamster Hepatic Microsomal N, O-Acetyltransferase
• Involvement of Human Blood Arylesterases and Liver Microsomal Carboxylesterases in Nafamostat Hydrolysis
• Effect of Ring Substituent on the Stability of the Epoxide Derived from Phenyl Vinyl Ether
• An Unstable Epoxy Intermediate Formed by the Microsomal Oxidation of 4-Nitrophenyl Vinyl Ether
• Metabolic Activation of Carcinogenic Arylmethanols by Sulfation : Microheterogeneity and Expression of Sulfotransferases (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
• NOVEL TYPE OF GLUTATHIONE S-TRANSFERASES (θCLASS) IN RAT LIVER CYTOSOL
• Metabolic Activation and Inactivation of Carcinogenic Arylmethanols : Rat Liver Cytosolic Sulfotransferases and Glutathione S-Transferases (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
• METABOLIC ACTIVATION OF CARCINOGENIC METHYL-SUBSTITUTED POLYNUCLEAR AROMATIC HYDROCARBONS BY HEPATIC P-450/SULFOTRANSFERASE : 7-METHYL- AND 7,12-DIMETHYLBENZ [α] ANTHRACENES AND 5-METHYL-CHRYSENE
• ROLE OF EPOXIDE IN THE METABOLIC TOXICATION OF VINYL ETHERS
• Accumulation of the Toxic Steroids, Cholesterol 7-Hydroperoxides, in Rat Skin and Their Glutathione-dependent Reduction (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
• "B-6 Accumulation of the toxic cholesterol 7-hydroperoxides in rat skin by aging and a glutathione-dependent reduction of the hydroperoxides.
• METABOLIC ACTIVATION OF DRUGS BY HEPATIC MICROSOMAL LIPID PEROXIDATION
• Hepatic Enzyme Systems that Mediate Activation and Inactivation of Olefins : Metabolism and Toxicity of Styrene (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
• DETOXICATION MECHANISMS FOR CARCINOGENIC EPOXIDES BY GLUTATHIONE S-TRANSFERASE
• The Role of Epoxides in the Metabolic Activation of Styrene to Mutagens (Regular Presentations) (Proceedings of the 8th Symposium on Environmental Pollutants and Toxicology)
• METABOLIC ACTIVATION AND INACTIVATION OF CARCINOGENS AND MUTAGENS INVOLVING EPOXIDES AS THEIR ULTIMATE FORMS
• The Reaction of S-Acylthiamine and 2-Mercaptoethanol
• RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
• Metal Response Element-binding Transcription Factor-1 Is Activated by Degradation of Metallothionein
• THE INADEQUACY OF THE RANEY NICKEL DESULFURATION METHOD FOR THE STRUCTURAL ELUCIDATION OF AN EPOXIDE-GLUTATHIONE S-CONJUGATE : DESULFURATION OF PHENYLOXIRAN-GLUTATHIONE S-CONJUGATES TO PHENYLOXIRAN
• MICROSOMAL METABOLISM OF d-LIMONENE AND MUTAGENICITY OF OLEFIN OXIDES TOWARD SALMONELLA TYPHIMURIUM
• Biotransformation of Styrene to Mutagenic 1-Vinylbenzene 3,4-Oxide by Hepatic Microsomes (Regular Presentations) (Proceedings of the 9th Symposium on Environmental Pollutants and Toxicology)
• DRUG OXIDATION BY ACTIVE OXYGENS FORMED DURING HEPATIC MICROSOMAL LIPID PEROXIDATION : METABOLIC ACTIVATION OF CARCINOGENS BY EPOXIDATION
• Liver Microsomal N, O-Acetyltransferase which Activates Carcinogenic Arylacetohydroxamic Acids
• Purification and Characterization of Hamster Hepatic Microsomal N, O-Acetyltransferase.
• EFFECT OF LIVER S9 FROM 3,4,5,3', 4'-PENTACHLOROBIPHENYL-PRETREATED RATS ON THE MUTAGENIC ACTIVITY OF THE VARIOUS CARCINOGENS TOWARD SALMONELLA TYPHIMURIUM TA 98
• ISOZYMES OF EPOXIDE HYDROLASE : CEHase AND XEHase
• THE ROLE OF L-REGION METHYL SUBSTITUENTS IN THE METABOLIC ACTIVATION OF THE POTENT CARCINOGEN, 7,12-DIMETHYLBENZ [a] ANTHRACENE (DMBA)
• ABSORPTION AND EXCRETION OF INDOMETHACIN GEL OINTMENT CONTAINING EGG LECITHIN
• Modification of Drug-Metabolizing Enzyme Activity of Rats in Carrageenin-Inflammation
• The Effect of AF2 [2-(2-Furyl)-3-(5-nitro-2-furyl) acrylamide] on Hepatic Microsomal Mixed Function Oxidase System in Rats
• Metabolism of Benzydamine Hydrochloride
• Comparative N-Demethylation of Antihistaminic Agents possessing Dimethylaminoalkyl Group by Liver Preparations from Four Animal Species
• The Inductive Effect of Mepirizole on the Drug Metabolizing Enzymes of Rat Liver
• The Metabolic Fate of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398) in Rats and Rabbits
• PHARMACOKINETIC STUDIES OF TRIMETHADIONE AND ITS METABOLITE IN RATS WITH CHEMICAL-INDUCED LIVER INJURY
• Studies on Natural p-Terphenyls: Total Syntheses of Vialinin A and Terrestrin B
• Vialinin A, a Novel Potent Inhibitor of TNF-α Production from RBL-2H3 Cells(Molecular and Cell Biology)
• Vialinin A, a Novel 2,2-Diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenger from an Edible Mushroom in China
• Protective Effect of Zinc against Lipopolysaccharide/D-Galactosamine-Induced Lethality
• COVALENT BINDING OF 7-HMBA SULFATE, A NEW ACTIVE METABOLITE OF DMBA, TO BIOMACROMOLECULES
• 7-Ethenyloxycoumarin as a New Substrate for Fluorophotometric Assay of Hepatic Microsomal Epoxidizing Activities
• Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300
• Age-related changes in hepatic drug-oxidizing activity using trimethadione as a probe drug in human
• Assessment of Benzydamine N-Oxidation Mediated by Flavin-Containing Monooxygenase in Different Regions of Rat Brain and Liver Using Microdialysis
• Effect of Cooking Process on the Deoxynivalenol Content and Its Subsequent Cytotoxicity in Wheat Products
• Glutathione S-Transferase Isozymes Responsible for Detoxication of Carcinogenic Epoxides
• STUDIES ON METABOLISM AND TOXICITY OF STYRENE. II. MUTAGENESIS IN SALMONELLA TYPHIMURIUM BY METABOLIC ACTIVATION OF STYRENE WITH 3-METHYLCHOLANTHRENE PRETREATED RAT LIVER
• STUDIES ON METABOLISM AND TOXICITY OF STYRENE. I. BIOTRANSFORMATION OF STYRENE TO STYRENE GLYCOL VIA STYRENE OXIDE BY RAT LIVER MICROSOMES
• In Vitro Inhibitory Effects of Pulvinic Acid Derivatives Isolated from Chinese Edible Mushrooms, Boletus calopus and Suillus bovinus, on Cytochrome P450 Activity
• Hydroxysteroid Sulfotransferase-mediated DNA Modification with Carcinogenic Polycyclic Hydroxymethylarenes (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
• THIOL S-SULFATES, A NEW TYPE OF ACTIVE METABOLITES
• Heterogeneity of Rat Liver Cytosolic Hydroxysteroid Sulfotransferase Activating Carcinogens
• A USEFUL MEASURE OF HEPATIC DRUG-OXIDIZING CAPACITY IN HUMANS : CAFFEINE AND TRIMETHADIONE ELIMINATION AS INDICATORS
• 326 A USEFUL MEASURE OF HEPATIC DRUG-OXIDIZING CAPACITY : CAFFEINE AND TRIMETHADIONE ELIMINATION AS THE INDICATORS
• The Metabolism and Excretion of Trimethadione in Patients with Percutaneous Transhepatic Biliary Drainage and Renal Dysfunction
• Sex-Related Differences in Hepatic Drug-Oxidizing Capacity of Streptozotocin-Induced Diabetic Rats
• TRIMETHADIONE METABOLISM IN PATIENTS WITH NORMAL LIVER AND IN PATIENTS WITH CHRONIC LIVER DISEASE
• HEPATIC TRIMETHADIONE-OXIDIZING CAPACITY REMAINS NORMAL IN PATIENTS WITH EXTRAHEPATIC CHOLELITHIASIS
• Detoxication of Ultimate Carcinogens by Rat Liver Zinc-Metallothionein (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
• No Immunotoxic Effect on T Cells with Di(2-Ethylhexyl)Phthalate in Male C57BL/6 Mice
• Differences in Enzymatic Properties of Flavin-Containing Monooxygenase in Brain Microsomes of Rat, Mouse, Hamster, Guinea Pig and Rabbit
• Metabolic Activation of Carcinogenic Arylamides by Liver Microsomal Carboxylesterase (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
• DEPLETION OF GLUTATHIONE AND HEPATO-TOXICITY CAUSED BY VINYL ETHERS IN MICE
• IN VITRO TOXICITY TEST OF POISONOUS MUSHROOM EXTRACTS WITH ISOLATED RAT HEPATOCYTES
• Comparative Studies on the Metabolism and Mutagenicity of Vinyl Ethers
• B30 EFFECT OF AFLATOXIN B_1 ON ISOLATED RAT HEPATOCYTES
• p-NITROPHENYL VINYL ETHER, A NOVEL SUBSTRATE FOR THE ASSAY OF CYTOCHROME P-450 DEPENDENT OLEFINIC EPOXIDATION IN HEPATIC MICROSOMES
• PURIFICATION AND CHARACTERIZATION OF HEPATIC MICROSOMAL ACYLTRANSFERASES IN DOGS
• B29 EFFECTS OF POISONOUS MUSHROOM EXTRACTS AND α-AMANITIN ON ISOLATED RAT HEPATOCYTES
• CHOLESTEROL DIET INCREASES PLASMA AND LIVER CONCENTRATIONS OF CHOLESTEROL EPOXIDES AND CHOLESTANETRIOL
• Effects of Mushroom Toxins on Glycogenolysis : Comparison of Toxicity of Phalloidin, α-Amanitin and DL-Propargylglycine in Isolated Rat Hepatocytes
• EFFECTS OF CIMETIDINE AND DIETHYLAMINOETHYL 2,2-DIPHENYLVALERATE HCL (SKF 525-A) ON TRIMETHADIONE METABOLISM IN THE RAT
• MECHANISTIC STUDIES ON THE MODIFICATION OF NUCLEIC ACIDS AND MUTAGENESIS BY 2-NAPHTHOHYDROXAMIC ACID
• Studies on Natural p-Terphenyls : Total Syntheses of Vialinin A and Terrestrin B
• In Vitro Inhibitory Effects of Pulvinic Acid Derivaties Isolated from Chinese Edible Mushrooms, Boletus calopus and Suillus bovinus, on Cytochrome P450 Activity
• Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300
• METABOLIC ACTIVATION OF 7, 12-DIMETHYLBENZ [a] ANTHRACENE (DMBA) AND 7-METHYLBENZ [a] ANTHRACENE (7-MBA) BY RAT LIVER P-450 AND SULFOTRANSFERASE

もっと見る 閉じる

スポンサーリンク