Differences in Enzymatic Properties of Flavin-Containing Monooxygenase in Brain Microsomes of Rat, Mouse, Hamster, Guinea Pig and Rabbit
スポンサーリンク
概要
- 論文の詳細を見る
To characterize flavin-containing monooxygenase (FMO) in brain microsomes of rat, mouse, hamster, guinea pig and rabbit, profiles of its enzyme activities were investigated by HPLC-fluorometrical assay using benzydamine (BZY) as a substrate. The optimum pH of BZY N-oxidation activity in brain microsomes from rat, mouse, hamster or guinea pig was between 8.5 and 9,though that of the rabbit brain microsomes was near 10.0. The activities were thermally unstable in brain microsomes from all the species examined in the absence of NADPH, but the activity in rabbit brain microsomes was rather thermostable in the presence of NADPH. The activity in rabbit brain microsomes was depressed in the presence of 5 mM n-octylamine. In the presence of MnCl_2,the enzyme activity in rabbit brain microsomes was markedly decreased. ZnCl_2 markedly decreased the enzyme activities in brain microsomes from rat, mouse and rabbit. It was concluded that BZY N-oxidation activity in brain microsomes from rat, mouse, hamster and guinea pig are similar in enzymatic properties but different from the activity of that rabbit. These results suggest that common FMO isoform(s) other than FMO-4 might exist in the brains of the four rodent species tested.
- 公益社団法人日本薬学会の論文
- 1997-08-15
著者
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ISOBE Masakazu
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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TAKABATAKE Eigo
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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Isobe M
Setsunan Univ. Osaka Jpn
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Isobe M
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Faculty Of Pharmaceutical Sciences University Of Setsunan
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KAWAJI AKIKO
Department of Micro System Engineering, Graduate School of Engineering, Nagoya University
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Takabatake E
Setsunan Univ. Osaka Jpn
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Takabatake Eigo
Department Of Pharmaceutical Sciences Institute Of Public Health
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Kawaji A
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Kawaji Akiko
Department Of Micro System Engineering Graduate School Of Engineering Nagoya University
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Kawaji Akiko
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Laboratory Of Drug Metabolism Ε-toxicology Department Of Hygienic Chemistry Tokyo College Of Pharmac
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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