DEPLETION OF GLUTATHIONE AND HEPATO-TOXICITY CAUSED BY VINYL ETHERS IN MICE
スポンサーリンク
概要
- 論文の詳細を見る
4-Nitrophenyl vinyl ether (NPVE) and phenyl vinyl ether (PVE) administered i.p. in mice lowered hepatic non-protein sulfhydryl (NP-SH) content, but did not elevate the serum glutamate pyruvate transaminase (GPT) activity. n-Butyl vinyl ether (BVE) showed no significant effects either on the NP-SH content or on the serum GPT activity. Mice pretreated with buthionine sulfoximine were sensitive to the potential toxicity of NPVE. These results showed that aryl vinyl ethers, NPVE and PVE, are more toxic than the alkyl vinyl ether, BVE, and that glutathione plays an important role on the protection of hepatic injury by reactive metabolite(s) derived from vinyl ethers.
- 日本トキシコロジー学会の論文
- 1995-05-25
著者
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SONE Tomomichi
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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ISOBE Masakazu
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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TAKABATAKE Eigo
Department of Toxicology, Faculty of Pharmaceutical Sciences, Setsunan University
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Sone T
Osaka Univ. Osaka Jpn
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Sone Tomomichi
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Sone Tomomichi
Laboratory Of Drug Metabolism And Toxicology Department Of Hygienic Chemistry Tokyo College Of Pharm
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Isobe M
Setsunan Univ. Osaka Jpn
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Isobe M
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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Isobe Masakazu
Faculty Of Pharmaceutical Sciences University Of Setsunan
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Takabatake E
Setsunan Univ. Osaka Jpn
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Sone Tomomichi
Faculty Of Pharmaceutical Sciences Setsunan University
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Takabatake Eigo
Department Of Pharmaceutical Sciences Institute Of Public Health
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Sone T
Setsunan Univ. Osaka Jpn
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Isobe Masakazu
Laboratory Of Drug Metabolism Ε-toxicology Department Of Hygienic Chemistry Tokyo College Of Pharmac
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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