TRIMETHADIONE METABOLISM IN PATIENTS WITH NORMAL LIVER AND IN PATIENTS WITH CHRONIC LIVER DISEASE
スポンサーリンク
概要
- 論文の詳細を見る
Serum dimethadione (DMO)/trimethadione (TMO) ratios after oral administration of TMO have been investigated in 10 patients with normal livers, 8 patients with hepatoma and 8 patients with hepatoma and cirrhosis. Serum concentration ratios of DMO to TMO at 4 h after oral administration of TMO in patients with chronic liver disease were significantly decreased by 27% for those with hepatoma and 52% for those with hepatoma and cirrhosis. Serum DMO/TMO ratios at 4 h correlated well with liver function characteristics (total protein r=0.741,plasma albumin r=0.826,total bilirubin r=-0.725,cholinesterase r=0.853) as well as with pharmacokinetic parameters (total body clearance r=0.852,half-life r=-0.636) in both patients with normal livers and patients with chronic liver disease. This study suggests that serum DMO/TMO ratios in a blood sample obtained by a single collection after an oral administration of TMO might provide a clinically useful index of the hepatic drug-oxidizing capacity in an individual patient with chronic liver disease without determining the liver function characteristics or the pharmacokinetic parameters.
- 公益社団法人日本薬学会の論文
著者
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Ishikawa Akio
筑波大学
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Ono Atsushi
Toxicogenomics Project National Institute Of Biomedical Innovation:national Institute Of Health Scie
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Ono Atsushi
Biological Safety Research Center National Institute Of Health Science
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Misawa S
Inst.of Commun.med
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Misawa Shogo
Institute Of Community Medicine University Of Tsukuba
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Okamura Takao
Institute Of Community Medicine:institute Of Clinical Medicine University Of Tsukuba:tsukuba Gakuen
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Ishikawa Akio
Institute Of Clinical Medicine University Of Tsukuba
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Ishikawa Akio
Inst.of Clin.med. Tsukuba Univ.
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Tanaka Einosuke
Institute Of Community Medicine And Institute Of Clinical Medicine University Of Tsukuba
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Tanaka E
Univ. Tsukuba Ibaraki Jpn
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Takabatake E
Department Of Toxicology Faculty Of Pharmaceutical Sciences Setsunan University
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ONO ATSUSHI
Institute of Community Medicine
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Takabatake E
Inst.of Commun.med
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Tanaka Einosuke
Inst.of Commun.med
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Ishikawa Akio
Institute For Solid State Physics University Of Tokyo
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MISAWA Shogo
Institute of Community Medicine
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