REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TOLUENE I. TERATOGENICITY STUDY OF INHALATION EXPOSURE IN PREGNANT RATS
スポンサーリンク
概要
- 論文の詳細を見る
Toluene is a widely used solvent in industry which is the subject of abuse among the younger generation. A teratogenicity study of toluene by inhalation exposure was carried out in Sprague-Dawley rats and the effects on dams, fetuses and offspring were assessed. Pregnant females were exposed to 600 or 2000 ppm toluene for 6 h/day from day 7 to day 17 of pregnancy. The control group inhaled conditioned clean air under the same exposure conditions. Maternal exposure to 2000 ppm toluene caused significant toxic effects such as body weight suppression of dams and offspring, high fetal mortality and embryonic growth retardation, but no external, internal or skeletal anomalies were observed in the fetuses of any treated group. In addition, there were no differences in the results of pre- and postweaning behavioral tests of the offspring. However, no toxic or teratogenic changes which could be related to toluene exposure were apparent in the 600 ppm group. Further studies are warranted with toluene at higher concentrations applied during the period of organogenesis.
- 日本トキシコロジー学会の論文
- 1995-05-25
著者
-
Hirose Akihiko
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science
-
KANEKO Toyozo
Division of Cellular and Molecular Toxicology, Kangwon National University
-
Hirose Akihiko
National Inst. Of Health Sciences
-
Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Satoh Kanako
東京都健康安全研究センター 環境保健部
-
Sai-kato Kimie
Division Of Toxicology
-
KANEKO Toyozo
National Center for Drug Safety Evaluation
-
Hirose Akihiko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
-
KUROKAWA Yuji
Division of Toxicology
-
Ono Atsushi
Division of Toxicology, National Institute of Health Sciences
-
Sekita Kiyoshi
Division of Toxicology, National Institute of Health Sciences
-
Ogawa Yukio
Division of Toxicology, National Institute of Health Sciences
-
Saito Minoru
Division of Toxicology, National Institute of Health Sciences
-
Naito Katsushi
Division of Toxicology, National Institute of Health Sciences
-
Furuya Tsuyoshi
Division of Toxicology, National Institute of Health Sciences
-
Matsumoto Kiyoshi
Institute of Experimental Animals, Shinshu University School of Medicine
-
Tanaka Satoru
Division of Toxicology, National Institute of Health Sciences
-
OHNO Keiko
Division of Toxicology, National Institute of Health Sciences
-
Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
-
TANAKA Satoru
Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.
-
Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
-
Ohno Keiko
Division Of Toxicology National Institute Of Health Sciences
-
Ohno Keiko
国立衛研
-
Ogawa Yumie
Fuji Gotemba Research Labs. Chugai Pharm. Co. Ltd.
-
Ono Atsushi
Toxicogenomics Project National Institute Of Biomedical Innovation:national Institute Of Health Scie
-
Ono Atsushi
Biological Safety Research Center National Institute Of Health Science
-
Saito Minoru
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
-
Saito Masako
Department Of Applied Physics University Of Tokyo:(present Address)institute For Solid State Physics
-
Tanaka Satoru
Division Of Pharmacology National Institute Of Hygienic Sciences
-
Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
-
SATO Michio
Div. of Medical Devices National Institute of Hygienic Sciences
-
FURUYA Tsuyoshi
Biological Safety Research Center, National Institute of Health Science
-
Ogawa Yukio
Fuji Gotemba Research Labs. Chugai Pharm. Co. Ltd.
-
Sugi M
Toin Univ. Yokohama Yokohama Jpn
-
Naito Katsushi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
-
Naitoh Katsusi
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
-
Kaneko Toyozo
Dlv. Of Toxicology Biological Safety Reseach Center National Institute Of Hygienic Sciences
-
Tanaka S
Toxicology Laboratory Kissei Pharmaceutical Co. Ltd.
-
Kaneko Toyozo
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
-
Kaneko T
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
-
Tanaka Satoru
Division Of Internal Medicine Shizuoka City Hospital
-
Furuya Tsuyoshi
Biological Safety Research Center National Institute Of Health Science
-
Naito K
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
-
Ono Atsushi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
-
Matsumoto Kiyoshi
Institute Of Experimental Animals Shinshu Univ.sch Of Med.
-
Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
-
Tanaka Satoru
Division Of Internal Medicine And Thoracic Surgery Shizuoka City Hospital
-
Hirose Akihiko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
-
Takayama Satoshi
Research Department Saitama Daiichi Pharmaceutical Co. Ltd. Japanese Pharmaceutical Manufacturers Association
-
OGAWA Yukio
Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
関連論文
- Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced rat pulmonary toxicity
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Relation between statistics and treatment-related changes obtained from toxicity studies in rats : if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change?
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- Evaluation of developmental toxicity of UV stabilizer 2-(3', 5'-di-tert-butyl-2'-hydroxyphenyl)-5-chlorobenzotriazole in rats(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Effects of progesterone on implantation failure induced by dibutyltin dichloride in rats (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- 3A-11 Effects of a peroxisome proliferator on DNA damage inducible-gene products induced by methyl methane sulfonate (MMS) in the primary hepatocytes culture of the rat
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- Reproductive and Developmental Toxicity Studies of Toluene.I.Teratogenicity Study of Inhalation Exposure in Pregnant Rats.
- REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TOLUENE I. TERATOGENICITY STUDY OF INHALATION EXPOSURE IN PREGNANT RATS
- THE TOXICITY STUDY OF BIODEGRADABLE PLASTIC IN RATS BY DIETARY ADMINISTRATION
- TWENTY-EIGHT-DAY REPEATED DOSE TOXICITY TESTS OF O-NITROTOLUENE IN WISTAR RATS
- ACUTE INHALATION TOXICITY TESTS OF DICHLOROSILANE AND TETRAFLUOROSILANE(THE SPECIALTY GASES)
- 306 A 28-DAY REPEATED DOSE TOXICITY TEST OF EUROPIUM AND GADORINIUM IN WISTAR RAT IN COMPARISON WITH LANTHANUM AND YTTRIUM
- 407 A 28-DAY REPEATED DOSE TOXICITY TEST OF LANTHANUM AND YTTRIUM IN WISTAR RAT
- 206 A 28-DAY REPEATED INHALATION TOXICITY TEST OF 2,2,3,3,3-PENTAFLUOROPROPANOL IN F344 RAT
- 21C-03-4 Effects of 2-Mercaptobenzimidazole (MBI) and its methyl derivatives MMBI on rat hepatic drug metabolizing enzymes.
- "B-11 Effects of triazine herbicides on isolated and primary cultured hepatocytes of rat.
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Comparison of the early gene responses of Ahr-activating chemicals using the Percellome system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- The development of Chemical Toxicogenomics Database by the "Percellome" system for the mechanism-based toxicology(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- Toxicity study of Garcinia cambogia extract (3) : Testicular toxicity of Hydroxycitric acid in mice(General toxicity, Proceedings of the 32nd Annual Meeting)
- Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effects of preparation methods for multi-wall carbon nanotube (MWCNT) suspensions on MWCNT induced rat pulmonary toxicity
- Peroxisome Proliferators Attenuate Free Arachidonic Acid Pool in the Kidney Through Inducing Lysophospholipid Acyltransferases
- "POINTS TO CONSIDER" REGARDING SAFETY ASSESSMENT OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS IN NON-CLINICAL STUDIES (ENGLISH TRANSLATION)
- Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
- REVISION AND ESTABLISHMENT OF JAPANESE DRINKING WATER QUALITY GUIDELINES FOR DI(2-ETHYLHEXYL) PHTHALATE, TOLUENE AND VINYL CHLORIDE : DIFFERENCES FROM THE LATEST WHO GUIDELINE DRAFTS
- Letter to the Editor
- Response to Letter to the Editor(2)
- Response to Letter to the Editor(1)
- Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
- Effects of Oseltamivir Phosphate (Tamiflu) and Its Metabolite (GS4071) on Monoamine Neurotransmission in the Rat Brain(Communications to the Editor)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Construction of Model Mice which Have Humanized Immune System.
- Construction of Model Mice Which Have Humanized Immune System
- Increase in in utero exposure to a migrant, 4,4'-butylidenebis(6-t-butyl-m-cresol), from nitrile-butadiene rubber gloves on brain aromatase activity in male rats
- Endocrine Disruptive Effects of Chemicals Eluted from Nitrile-Butadiene Rubber Gloves Using Reporter Gene Assay Systems(Molecular and Cell Biology)
- In Vitro Screening Assay for Detecting Aromatase Activity Using Rat Ovarian Microsomes and Estrone ELISA(Biochemistry)
- In Vitro Screening of Psychoactive Drugs by [^S]GTPγS Binding in Rat Brain Membranes(Pharmacology)
- Androgenic and Antiandrogenic Effects of Alkylphenols and Parabens Assessed Using the Reporter Gene Assay with Stably Transfected CHO-K1 Cells (AR-EcoScreen System)
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- 2A-13 Reproductive and Developmental Toxicity Studies of Toluene. III. Prenatal and postnatal study by inhalation exposure in rats.
- A 13-WEEK TOXICITY STUDY OF SIMULTANEOUS ADMINISTRATION OF COCHINEAL AND ALUMINUM POTASSIUM SULFATE IN RATS
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-ISOBUTYLIDENEBIS (4,6-DIMETHYLPHENOL) IN RATS
- Analysis of the effect of dietary phytoestrogens on the gene expression profiles of endocrine disruptors using the "Percellome" system(Toxicogenomics, Toxicoproteomics, Proceedings of the 32nd Annual Meeting)
- P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Toxicity study of Garcinia cambogia extract II : A28-day dietary exposure of hydroxycitric acid, a principal ingredient of Garcinia cambogia extract, on testicular toxicity in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings
- Toxicity study of Garcinia canbogia extract I : A 52-week-toxicity study of Garcinia cambogia extract in rats (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- Effects of granulocyte-colony stimulatig factor in newborn rats.
- Sample surveillance for clinical pathology testing.
- RESULTS OF A 28-MONTH CHRONIC INHALATION TOXICITY STUDY OF FORMALDEHYDE IN MALE FISHER-344 RATS
- "P-27 Local irritation effects in the nasal cavity and the nasopharyngeal epithelia of the rat treated per os for 10 days with repeated doses of N-(fluorodichloromethylthio) phthalimide ("fluor-folpet").
- B-22 A 28-DAY REPEATED DOSE TOXICITY TEST AND THE TIME COURSE OF CHOLINESTERASE ACTIVITY TEST FOR CHLORPYRIFOS IN WISTAR RAT
- C07 TOXICITY OF 2-MERCAPTOBENZOTHIAZOLE(MBT) IN MICE
- C06 TOXICOLOGICAL STUDY ON 2-(4-MORPHOLINOTHIO)BENZOTHIAZOLE (2-MTBT) IN MICE
- CHRONIC TOXICITY STUDY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) IN MICE
- "C-5 Validation of alternatives to eye irritation tests for cosmetic ingredients (Results of the first, second, and third validation).
- Metabolism of 2,2,3,3,3-Pentafluoropropanol (5-FP) in Rats (Proceedings of the 20th Symposium on Toxicology and Environmental Health)
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (2ND REPORT) SUBACUTE TOXICITY IN MICE
- P12-03 Is Nrf2 gene Involved in benzene metabolic pathway?
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
- SEMI-QUANTITATIVE IMMUNOHISTOCHEMICAL ANALYSIS OF MALE RAT-SPECIFIC α_2u-GLOBULIN ACCUMULATION FOR CHEMICAL TOXICITY EVALUATION
- Risk assessment for the endocrine distruption effects by bisphenol A (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- P10-17 Risk assessment for formaldehyde in drinking water via oral and inhalation exposure.
- P-75 Toxicity evaluation of a strong mutagen MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) in drinking water.(Proceedings of the 27th Annual Meeting)
- TOXICOLOGICAL EFFECTS OF SOME INHALED CHEMICALS ON THE RESPIRATORY TRACT AND THE LUNGS OF RATS (first report)
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) III TRANSFER THROUGH THE MATERNAL MILK AND EFFECT OF 2-MIZ TO THE OFFSPRING MICE
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (1ST REPORT) ACUTE TOXICITY AND IMMUNOTOXICITY OF 2-MIZ IN MICE
- Subcellular Distribution of Rat Liver NADPH-2,4-Dienoyl-CoA Reductase
- STUDIES ON DAIZE EYE IRRITATION TEST AND CORRELATION TO HISTOPATHOLOGICAL FINDINGS
- Principles of risk assessment for determining the safety of chemicals : Recent assessment of residual solvents in drugs and di(2-ethylhexyl) phthalate
- Disappearance of gender-related difference in the toxicity of benzotriazole ultraviolet absorber in juvenile rats
- Placental-transfer of tetrabromobisphenol A in mice(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE.(GENERAL SESSION BY POSTER PRESENTATION)(DEVELOPMENT AND REPRODUCTION)
- EFFECTS OF METYRAPONE ON PLASMA CORTICOSTERONE LEVELS AND INCIDENCE OF CLEFT PALATE IN PREGNANT ddY-Slc MICE FED POLYCHLORINATED TERPHENYLS
- INHALATION TOXICITY STUDY OF FORMALDEHYDE (NASAL CAVITY CANCER OF RATS)
- Influence of coefficient of variation in determining significant difference of quantitative values obtained from 28-day repeated-dose toxicity studies in rats
- Fullerene (C_) Is Negative in the In Vivo Pig-A Gene Mutation Assay
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- WI-05 Future Perspective of Safety Evaluation on Biotechnology-derived Pharmaceutical Products.
- Report 3 : BIOTECHNOLOGY PRODUCTS : SPECIFIC ISSUES AND ICH S6 (Safety assessment of biotechnology-derived pharmaceutical product.)
- Toxicological bases for micro-dose study(Toxicological Bases for Micro-dose Study, Proceedings of the 32nd Annual Meeting)
- Clofibric Acid Increases the Formation of Oleic Acid in Endoplasmic Reticulum of the Liver of Rats
- Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
- Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
- Determination of dose dependence in repeated dose toxicity studies when mid-dose alone is insignificant
- Repeated dose and reproductive/developmental toxicity of perfluorooctadecanoic acid in rats
- No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats
- Sub-acute oral toxicity study with fullerene C60 in rats
- A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats
- P-061(O-9) Using Existing In Vitro Structural Alters For Chromosome Damage To Predict In Vivo Activity And Direct Future Testing(Poster presentation)