Report 3 : BIOTECHNOLOGY PRODUCTS : SPECIFIC ISSUES AND ICH S6 (<Session 6B>Safety assessment of biotechnology-derived pharmaceutical product.)
スポンサーリンク
概要
- 論文の詳細を見る
- 日本トキシコロジー学会の論文
- 1996-12-20
著者
-
KANEKO Toyozo
Division of Cellular and Molecular Toxicology, Kangwon National University
-
KANEKO Toyozo
National Center for Drug Safety Evaluation
-
INOUE Tohru
Center for Biological Safety and Research
-
Takagi Atsuya
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
-
Inoue Tohru
Division Of Toxicol. Mutagen. Nihs
-
Takagi Atsuya
Division Of Toxicology National Institute Of Health Sciences
-
Kaneko Toyozo
Division Of Cellular And Molecular Toxicology Kangwon National University
-
Kaneko Toyozo
Dlv. Of Toxicology Biological Safety Reseach Center National Institute Of Hygienic Sciences
-
Kaneko Toyozo
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
-
Kaneko T
Division Of Toxicology Biological Safety Research Center National Institute Of Health Sciences
-
Takagi Atsuya
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
-
Inoue Tohru
Division Of Cellular And Molecular Toxicology Center For Biological Safety And Research National Ins
-
Inoue Tohru
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
関連論文
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- 3A-11 Effects of a peroxisome proliferator on DNA damage inducible-gene products induced by methyl methane sulfonate (MMS) in the primary hepatocytes culture of the rat
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- Reproductive and Developmental Toxicity Studies of Toluene.I.Teratogenicity Study of Inhalation Exposure in Pregnant Rats.
- REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDIES OF TOLUENE I. TERATOGENICITY STUDY OF INHALATION EXPOSURE IN PREGNANT RATS
- THE TOXICITY STUDY OF BIODEGRADABLE PLASTIC IN RATS BY DIETARY ADMINISTRATION
- TWENTY-EIGHT-DAY REPEATED DOSE TOXICITY TESTS OF O-NITROTOLUENE IN WISTAR RATS
- ACUTE INHALATION TOXICITY TESTS OF DICHLOROSILANE AND TETRAFLUOROSILANE(THE SPECIALTY GASES)
- 306 A 28-DAY REPEATED DOSE TOXICITY TEST OF EUROPIUM AND GADORINIUM IN WISTAR RAT IN COMPARISON WITH LANTHANUM AND YTTRIUM
- 407 A 28-DAY REPEATED DOSE TOXICITY TEST OF LANTHANUM AND YTTRIUM IN WISTAR RAT
- 206 A 28-DAY REPEATED INHALATION TOXICITY TEST OF 2,2,3,3,3-PENTAFLUOROPROPANOL IN F344 RAT
- Toxicity study of Garcinia cambogia extract (3) : Testicular toxicity of Hydroxycitric acid in mice(General toxicity, Proceedings of the 32nd Annual Meeting)
- Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Aryl hydrocarbon receptor (AhR) mediated hematotoxicity induced by benzene.(GENERAL SESSION BY ORAL PRESENTATION)(BLOOD SYSTEM & HEMATOLOGY)
- Effects of Neopterin on the Hematopoietic Microenvironment of Senescence-Accelerated Mice (SAM)(Molecular and Cell Biology)
- Letter to the Editor
- Response to Letter to the Editor(2)
- Response to Letter to the Editor(1)
- Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Construction of Model Mice which Have Humanized Immune System.
- Construction of Model Mice Which Have Humanized Immune System
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- 2A-13 Reproductive and Developmental Toxicity Studies of Toluene. III. Prenatal and postnatal study by inhalation exposure in rats.
- P11-16 EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-ISOBUTYLIDENEBIS (4,6-DIMETHYLPHENOL) IN RATS
- P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Toxicity study of Garcinia cambogia extract II : A28-day dietary exposure of hydroxycitric acid, a principal ingredient of Garcinia cambogia extract, on testicular toxicity in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings
- Toxicity study of Garcinia canbogia extract I : A 52-week-toxicity study of Garcinia cambogia extract in rats (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- ACUTE, SUBCHRONIC AND CHRONIC TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYLPHENOL) IN RATS
- RESULTS OF A 28-MONTH CHRONIC INHALATION TOXICITY STUDY OF FORMALDEHYDE IN MALE FISHER-344 RATS
- "P-27 Local irritation effects in the nasal cavity and the nasopharyngeal epithelia of the rat treated per os for 10 days with repeated doses of N-(fluorodichloromethylthio) phthalimide ("fluor-folpet").
- CHRONIC ORAL TOXICITY STUDY OF A SYNTHETIC ANTIOXIDANT, 2, 2'-METHYLENEBIS(4-ETHYL-6-TERT-BUTYLPHENOL)(MBEBP)IN RATS
- TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS (4-ETHYL-6-TERT-BUTYLPHENOL) IN RATS 1. ACUTE AND SUBCHRONIC TOXICITY
- B-30 STUDY ON ESSENYIAL METAL CONCENTRATION IN THE ORGANS OF RATS
- B-22 A 28-DAY REPEATED DOSE TOXICITY TEST AND THE TIME COURSE OF CHOLINESTERASE ACTIVITY TEST FOR CHLORPYRIFOS IN WISTAR RAT
- C07 TOXICITY OF 2-MERCAPTOBENZOTHIAZOLE(MBT) IN MICE
- C06 TOXICOLOGICAL STUDY ON 2-(4-MORPHOLINOTHIO)BENZOTHIAZOLE (2-MTBT) IN MICE
- B38 COMPARISON OF TOXICITY OF p-DCB IN MALE AND FEMALE RATS
- CHRONIC TOXICITY STUDY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) IN MICE
- JaCVAM statement on new alternatives to animal testing
- "C-5 Validation of alternatives to eye irritation tests for cosmetic ingredients (Results of the first, second, and third validation).
- Results from Draize eye-irritation test and implications of their variations.
- Validation of alternative methods to eye irritaion test for safety evaluation of cosmetic ingredients, project and progress.
- Letter to the Editor(1)
- "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (2ND REPORT) SUBACUTE TOXICITY IN MICE
- P12-03 Is Nrf2 gene Involved in benzene metabolic pathway?
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
- "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
- TOXICITY STUDIES OF A SYNTHETIC ANTIOXIDANT, 2,2'-METHYLENEBIS (4-ETHYL-6-TERT-BUTYLPHENOL) IN RATS 2. UNCOUPLING EFFECT ON OXIDATIVE PHOSPHORYLATION OF LIVER MITOCHONDRIA
- TOXICOLOGICAL EFFECTS OF SOME INHALED CHEMICALS ON THE RESPIRATORY TRACT AND THE LUNGS OF RATS (2nd report)
- TOXICOLOGICAL EFFECTS OF SOME INHALED CHEMICALS ON THE RESPIRATORY TRACT AND THE LUNGS OF RATS (first report)
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) III TRANSFER THROUGH THE MATERNAL MILK AND EFFECT OF 2-MIZ TO THE OFFSPRING MICE
- TOXICITY OF 2-MERCAPTOIMIDAZOLINE (2-MIZ) (1ST REPORT) ACUTE TOXICITY AND IMMUNOTOXICITY OF 2-MIZ IN MICE
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- Estimation of Acute Inhalation Toxicity (LC_) from Acute Toxicity (LD_) of Other Exposure Routes (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- P10-07 BASIC PROPERTIES OF UTEROTROPIC RESPONSE.
- STUDIES ON DAIZE EYE IRRITATION TEST AND CORRELATION TO HISTOPATHOLOGICAL FINDINGS
- EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE.(GENERAL SESSION BY POSTER PRESENTATION)(DEVELOPMENT AND REPRODUCTION)
- EFFECTS OF METYRAPONE ON PLASMA CORTICOSTERONE LEVELS AND INCIDENCE OF CLEFT PALATE IN PREGNANT ddY-Slc MICE FED POLYCHLORINATED TERPHENYLS
- INHALATION TOXICITY STUDY OF FORMALDEHYDE (NASAL CAVITY CANCER OF RATS)
- THE INTERACTION OF POLYCHLORINATED BIPHENYLS AND METHYLMERCURY CHLORIDE IN RATS
- Safety evaluation of biotechnology-derived pharmaceuticals : present and future(WORKSHOP 1 : THE WAY TOXICITY EVALUATIONS OF BIO-PHARMACEUTICAL PRODUCTS SHOULD BE CONDUCTED (TOXICOLOGICAL QUESTIONS & ANSWERS-ISSUE 2002).ICH-S6)
- "A-13 p-Phenylenediamines, antioxidative ingredients for rubber compound : a quantitative evaluation of their skin sensitization in guinea pig (GPMT)
- Fullerene (C_) Is Negative in the In Vivo Pig-A Gene Mutation Assay
- ACUTE AND CHRONIC TOXICITY OF DIISOPROPYLNAPHTHALENE
- Single-dose Toxicities of 2,5-Di(Tert-Butyl)-1,4-Hydroquinone In the Rat : Toxicants as of Hydroquinone Derivative or a Microsomal Ca^ ATPase Inhibitor?
- WI-05 Future Perspective of Safety Evaluation on Biotechnology-derived Pharmaceutical Products.
- Report 3 : BIOTECHNOLOGY PRODUCTS : SPECIFIC ISSUES AND ICH S6 (Safety assessment of biotechnology-derived pharmaceutical product.)
- Serum-free culture of murine embryonic stem (ES) cells for the analysis of developmental toxicity(Development, Reproduction, Proceedings of the 32nd Annual Meeting)
- Additive Estrogenic Effect Of Genistein And Bisphenol A, And Anti-Estrogenic Effect Of (-)-Epigallocatechin Gallate In MCF-7 Cells.
- Rapid screening method of endocrine disrupting chemicals using surface plasmon resonance sensor (ENDOCRINE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- W2-1 BIOTECHNOLOGY-DERIVED RECOMBINANT ANIMALS FOR TOXICOLOGICAL EVALUATION AND RESEARCH.(Proceedings of the 27th Annual Meeting)
- Radiation Injury and the Chernobyl Catastrophe
- Future prospect of humanized experimental animal model for toxicological evaluation.
- Ovariectomized mouse uterotrophic assay of 36 chemicals
- Response to Letter to the Editor(2)