Safety evaluation of biotechnology-derived pharmaceuticals : present and future(WORKSHOP 1 : THE WAY TOXICITY EVALUATIONS OF BIO-PHARMACEUTICAL PRODUCTS SHOULD BE CONDUCTED (TOXICOLOGICAL QUESTIONS & ANSWERS-ISSUE 2002).ICH-S6)
スポンサーリンク
概要
著者
-
INOUE Tohru
Center for Biological Safety and Research
-
Kitajima Satoshi
Center For Biological Safety & Research National Institute Of Health Sciences
-
Inoue Tohru
Center For Biological Safety & Research National Institute Of Health Sciences
関連論文
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- 3A-11 Effects of a peroxisome proliferator on DNA damage inducible-gene products induced by methyl methane sulfonate (MMS) in the primary hepatocytes culture of the rat
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- "C-1 Reproductive and Developmental Toxicity Studies of Toluene. : II. Effects of inhalation exposure on fertility in rats.
- Toxicity study of Garcinia cambogia extract (3) : Testicular toxicity of Hydroxycitric acid in mice(General toxicity, Proceedings of the 32nd Annual Meeting)
- Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Aryl hydrocarbon receptor (AhR) mediated hematotoxicity induced by benzene.(GENERAL SESSION BY ORAL PRESENTATION)(BLOOD SYSTEM & HEMATOLOGY)
- ASSESSMENT OF QUANTITATIVE DUAL-PARAMETER FLOW CYTOMETRIC ANALYSIS FOR THE EVALUATION OF TESTICULAR TOXICITY USING CYCLOPHOSPHAMIDE -AND ETHINYLESTRADIOL- TREATED RATS
- O10-14 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Adriamcycin and Ethynylestradiol in Rats.
- Construction of Model Mice which Have Humanized Immune System.
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- 2A-13 Reproductive and Developmental Toxicity Studies of Toluene. III. Prenatal and postnatal study by inhalation exposure in rats.
- P11-16 EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE
- P7-35 Three-months dietary toxicity study of o-cymen-5-ol(biosol) in rats : Biosol induced renal injury and thymocyte apoptosis(GENERAL TOXICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Toxicity study of Garcinia cambogia extract II : A28-day dietary exposure of hydroxycitric acid, a principal ingredient of Garcinia cambogia extract, on testicular toxicity in rats. (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings
- Toxicity study of Garcinia canbogia extract I : A 52-week-toxicity study of Garcinia cambogia extract in rats (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- "P-27 Local irritation effects in the nasal cavity and the nasopharyngeal epithelia of the rat treated per os for 10 days with repeated doses of N-(fluorodichloromethylthio) phthalimide ("fluor-folpet").
- "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
- P12-03 Is Nrf2 gene Involved in benzene metabolic pathway?
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
- "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
- O-2 The Assessment of Dual Parameter Flow Cytometry Analysis to Detect the Testicular Toxicity Caused with Cyclophosphamide in Rats.(Proceedings of the 27th Annual Meeting)
- P10-07 BASIC PROPERTIES OF UTEROTROPIC RESPONSE.
- EFFECTS OF TCDD ON THE GENE EXPRESSION IN MOUSE EMBRYONIC STEM CELLS IN CULTURE.(GENERAL SESSION BY POSTER PRESENTATION)(DEVELOPMENT AND REPRODUCTION)
- Safety evaluation of biotechnology-derived pharmaceuticals : present and future(WORKSHOP 1 : THE WAY TOXICITY EVALUATIONS OF BIO-PHARMACEUTICAL PRODUCTS SHOULD BE CONDUCTED (TOXICOLOGICAL QUESTIONS & ANSWERS-ISSUE 2002).ICH-S6)
- WI-05 Future Perspective of Safety Evaluation on Biotechnology-derived Pharmaceutical Products.
- Report 3 : BIOTECHNOLOGY PRODUCTS : SPECIFIC ISSUES AND ICH S6 (Safety assessment of biotechnology-derived pharmaceutical product.)
- W2-1 BIOTECHNOLOGY-DERIVED RECOMBINANT ANIMALS FOR TOXICOLOGICAL EVALUATION AND RESEARCH.(Proceedings of the 27th Annual Meeting)
- Report of current activities of the IUTOX (2004-2007)(Qualification test system and international situation, Proceedings of the 32nd Annual Meeting)
- Toxicogenomics opens new paradigm of toxicology(PANEL DISCUSSION : THE FUTURE OF TOXICOLOGY IN REGULATORY DECISION MAKING, YEAR 2002)