Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
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概要
- 論文の詳細を見る
Nanomaterials of carbon origin tend to form various shapes of particles in micrometer dimensions. Among them, multi-wall carbon nanotubes (MWCNT) form fibrous or rod-shaped particles of length around 10 to 20 micrometers with an aspect ratio of more than three. Fibrous particles of this dimension including asbestos and some man-made fibers are reported to be carcinogenic, typically inducing mesothelioma. Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos. Our results point out the possibility that carbon-made fibrous or rod-shaped micrometer particles may share the carcinogenic mechanisms postulated for asbestos. To maintain sound activity of industrialization of nanomaterials, it would be prudent to implement strategies to keep good control of exposure to fibrous or rod-shaped carbon materials both in the workplace and in the future market until the biological/carcinogenic properties, especially of their long-term biodurability, are fully assessed.
- 日本トキシコロジー学会の論文
- 2008-02-15
著者
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Hirose Akihiko
Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science
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OHASHI Norio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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OGATA Akio
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Ogata Akio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ogata Akio
東京都健康安全研究センター
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Ogata Akio
東京都健康安全研究センター 環境保健部
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KANNO Jun
Division of Cellular and Molecular Toxicology, Kangwon National University
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Hirose Akihiko
National Inst. Of Health Sciences
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Nishimura Tetsuji
Environmental Chemistry National Institute Of Health Sciences
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Kitajima Satoshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Satoh Kanako
東京都健康安全研究センター 環境保健部
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Satoh Kanako
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ohashi Norio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ohashi Norio
東京都健康安全研究センター
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NISHIMURA Tetsuji
Division of Environmental Health, National Institute of Health Sciences
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Shirao Kuniaki
Gastrointestinal Oncology Division National Cancer Center Hospital
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Sai Kimie
Divislon Of Toxicology National Institute Of Health Sciences
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Sai-kato Kimie
Division Of Toxicology
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Hirose Akihiko
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Sekita Kiyoshi
Division Of Cellular & Molecular Toxicology National Institute Of Health Sciences
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KITAJIMA Satoshi
Division of Cellular and Molecular Toxicology, BSRC, National Institute of Health Sciences
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Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
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Nishimura Tetsuji
Division Of Environmental Chemistry
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Kanno Jun
Division Of Molecular Toxicology National Institute Of Health Sciences
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Kanno Jun
New Business Development Biacore K. K.
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Takagi Atsuya
Division Of Cellular And Molecular Toxicology Biological Safety Research Center National Institute O
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Takagi Atsuya
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
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Fukumori Nobutaka
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Sakemi Kazue
Division Of Pharmacology And Biological Safety Research Center National Institute Of Health Sciences
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Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
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Takagi Atsuya
Division Of Toxicology National Institute Of Health Sciences
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Kitajima S
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Kanno Jun
国立医薬品食品衛生研究所安全性生物試験研究センター
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Ohashi Norio
Department Of Dermatology Saitama Medical Center Saitama Medical School
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Kanno Jun
Cel. Mol. Tox. Div. Nihs
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Kitajima S
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Kitajima Satoshi
Division Of Cellular And Molecular Toxicology Biological Safety Research Center National Institute O
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Hirose Akihiko
National Inst. Of Health Sciences (nihs)
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Fukumori Nobutaka
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Kanno Jun
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Kanno Jun
Division Of Toxicology National Institute Of Health Sciences
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Takagi Atsuya
Division Of Cellular & Molecular Toxicology Center For Biological Safety Research National Insti
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Kanno Jun
Division Of Cellular & Molecular Toxicology Biological Safety Research Center National Institute
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Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Hirose Akihiko
Division Of Risk Assessment Biological Safely Research Center National Institute Of Health Sciences
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