Relation between statistics and treatment-related changes obtained from toxicity studies in rats : if detected a significant difference in low or middle dose for quantitative values, this change is considered as incidental change?
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of a toxicity test is to determine the no-observed-effect level (NOEL) of test substance through biological and pharmacological techniques. If the low dose not does show statistically significant and biologically relevant changes in the data evaluated in a study, the usual practice is to consider this dose as the NOEL. To overcome this, 6 types of techniques that seemed to be appropriate are presented in this paper by investigating the results of several domestic and foreign theses on toxicology. The most appropriate techniques appear to be the trend test, comparison between treatment group and historical control by t-test, and confirmation that all individual values lie within the 95% confidence interval (2 SD) of the historical control value, if a significant difference is admitted in the low dose.
- 2010-02-01
著者
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Hirose Akihiko
National Institute Of Health Sciences
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Hirose Akihiko
National Inst. Of Health Sciences
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KOBAYASHI Katsumi
Chemical Management Center, National Institute of Technology and Evaluation
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SAKURATANI Yuki
Chemical Management Center, National Institute of Technology and Evaluation
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ABE Takemaru
Chemical Management Center, National Institute of Technology and Evaluation
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NISHIKAWA Satoshi
Chemical Management Center, National Institute of Technology and Evaluation
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YAMADA Jun
Chemical Management Center, National Institute of Technology and Evaluation
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KAMATA Eiichi
National Institute of Health Sciences
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HAYASHI Makoto
Chemical Management Center, National Institute of Technology and Evaluation
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Hirose Akihiko
Division Of Risk Assessment National Institute Of Health Sciences
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Abe Takemaru
Chemical Management Center National Institute Of Technology And Evaluation
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Kamata E
National Institute Of Health Sciences
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Kobayashi Kinji
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Nishikawa Satoshi
Chemical Management Center National Institute Of Technology And Evaluation
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Hirose Akihiko
Division Of Toxicology National Institute Of Health Sciences
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Kamata Eiichi
Division Of Risk Assessment Biological Safety Research Center National Institute Of Health Sciences
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Kamata Eiichi
National Institute Of Hygienic Sciences
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Kobayashi K
Drug Safety Research Laboratories Tanabe Seiyaku Co. Ltd.
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Hirose Akihiko
National Inst. Of Health Sciences (nihs)
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Hayashi Makoto
Chemical Management Center National Inst. Of Technol. And Evaluation (nite)
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Kamata Eiichi
National Inst. Of Health Sciences (nihs)
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Sakuratani Yuki
Chemical Management Center National Institute Of Technology And Evaluation (nite)
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Kobayashi Katsumi
Chemical Management Center National Institute Of Technology Evaluation
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Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Yamada Jun
Chemical Management Center National Institute Of Technology And Evaluation (nite)
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Kobayashi Katsumi
Chemical Management Center National Institute Of Technology And Evaluation (nite)
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Yamada Jun
Chemical Management Center National Institute Of Technology And Evaluation
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Sakuratani Yuki
Chemical Management Center National Institute Of Technology And Evaluation
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