Long-term Pulmonary Responses to Quadweekly Intermittent Intratracheal Spray Instillations of Magnetite (Fe3O4) Nanoparticles for 52 Weeks in Fischer 344 Rats
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概要
- 論文の詳細を見る
Information about potential risks of iron nanomaterials is still limited, while a wide variety of applications are expected. We recently reported acute phase responses of male and female Fischer 344 rats after a single intratracheal spray instillation of Fe3O4 nanoparticles (magnetite), clearly showing dose-dependent pulmonary inflammatory changes (Tada et al., J Toxicol Pathol 25, 233–239, 2012). The present study assessed long-term responses of male and female Fischer 344 rats to multiple administrations of magnetite. Ten-week-old male and female Fischer 344 rats (n=20/group) were exposed to a total of 13 quadweekly intermittent intratracheal spray instillations of magnetite during the experimental period of 52 weeks, at doses of 0, 0.2 (low), 1.0 (medium) and 5.0 (high-dose) mg/kg body weight per administration. Absolute and relative lung weights of the high-dose group were significantly higher than those of the control group. Macroscopically, slight enlargement and scattered black patches were recognized in the lungs and the lung-associated lymph nodes of the high-dose group. Histopathologically, infiltration of macrophages phagocytosing magnetite (all dose groups) and of chronic inflammatory cells (medium- and high-dose males and high-dose females), alveolar bronchiolization and granuloma (high-dose group) were observed. In addition, alveolar hyperplasias were observed in some rats of the high-dose group, and cytoplasmic overexpression of β-catenin protein was immunohistochemically found in such lesions. The present results clearly show that instilled magnetite causes chronic inflammatory responses in the lung. These responses occur in a dose-dependent manner without apparent differences among sexes.
- 日本毒性病理学会の論文
著者
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Ogata Akio
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Nakae Dai
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Kubo Yoshikazu
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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TADA Yukie
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
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Yano Norio
Department Of Electronics Faculty Of Engineering Kyushu University
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Nagasawa Akemichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Yuzawa Katsuhiro
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ando Hiroshi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Takahashi Hiroshi
Department Of Applied Aquabiology National Fisheries University
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Ando Hiroshi
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku, Tokyo 169-0073, Japan
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Ogata Akio
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku, Tokyo 169-0073, Japan
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Inomata Akiko
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku, Tokyo 169-0073, Japan
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Kubo Yoshikazu
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku, Tokyo 169-0073, Japan
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Yano Norio
Department of Applied Chemistry, University of Osaka Prefecture
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