Study of 1,4-Dioxane Intake in the Total Diet Using the Market-Basket Method
スポンサーリンク
概要
- 論文の詳細を見る
1,4-Dioxane has been classified by the US Environmental Protection Agency and the International Agency for Research on Cancer as a compound that may be carcinogenic in humans. Although there are several reports of 1,4-dioxane being detected in the environment, such as in tap water, there have been few reports on the content of 1,4-dioxane in food. We therefore studied the intake of 1,4-dioxane in food based on the average intake of food in the Kanto area of Japan as reported by the Ministry of Health, Labor and Welfare. The food was cooked in the normal manner and then homogenized in a mixer. A 20 g of sample of the homogenate was added to a solution of the purified water with 0.2 μg of 1,4-dioxane-d_8 as a surrogate and the 200 ml azeotropic solution was recovered using the steam distillation method. This solution was applied to a pair of active carbon solid-phase cartridges and the analyte was eluted from each cartridge with dichloromethane. The eluted solution was prepared for gas chromatographic/mass spectrometric analysis by reduction to a volume of 1 ml under a gentle stream of nitrogen. The detection limit of the analysis was 2 μg/kg. We found that the 1,4-dioxane content of 12 food groups ranged between 2 μg/kg and 15 μg/kg. From these results, the total daily intake of 1,4-dioxane was calculated to be 0.440 μg. An intake of this magnitude corresponds to 0.055% of the calculated total daily intake (TDI) (16 μg/kg body weight/day). This study indicates that the amount of 1,4-dioxane intake contributed by food is very low and that this value does not represent a potential problem as it does not raise the risk of carcinogenesis.
- 社団法人日本薬学会の論文
- 2004-02-01
著者
-
Nishimura Tetsuji
Environmental Chemistry National Institute Of Health Sciences
-
Nishimura Tetsuji
Div. Of Environmental Chemistry National Inst. Of Health Sciences
-
Nishimura T
National Inst. Of Health Sci. Tokyo Jpn
-
NISHIMURA Tetsuji
Division of Environmental Health, National Institute of Health Sciences
-
Nishimura Tetsuji
Division Of Environmental Chemistry
-
Nishimura Tetsuji
Division Of Environmental Chemistry National Institute Of Health Sciences
-
Iizuka Seiichiro
Section of Applied Testing, Japan Food Research Laboratories Osaka Branch
-
Kibune Nobuyuki
Section of Applied Testing, Japan Food Research Laboratories Osaka Branch
-
Ando Masanori
Division of Environmental Chemistry, National Institute of Health Sciences
-
Kibune Nobuyuki
Section Of Applied Testing Japan Food Research Laboratories Osaka Branch:(present Address)section Of
-
Ando Masanori
Division Of Environmental Chemistry National Institute Of Health Sciences
-
Ando Masanori
Division Of Environmental Chemistry National Institute Of Health Science
-
Iizuka Seiichiro
Section Of Applied Testing Japan Food Research Laboratories Osaka Branch:(present Address)section Of
関連論文
- Serum level of expressed in renal carcinoma (ERC)/ mesothelin in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube (MWCNT)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Analysis of Active Oxon Forms of Nine Organophosphorus Pesticides in Water Samples Using Gas Chromatography with Mass Spectrometric Detection
- Effects of coating materials and size of titanium dioxide particles on their cytotoxicity and penetration into the cellular membrane
- Study of 1, 4-Dioxane Intake in the Total Diet
- Study of 1,4-Dioxane Intake in the Total Diet Using the Market-Basket Method
- Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats
- Letter to the Editor
- Response to Letter to the Editor(2)
- Response to Letter to the Editor(1)
- Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube
- Estrogenic Activities of UV Stabilizers Used in Food Contact Plastics and Benzophenone Derivatives Tested by the Yeast Two-Hybrid Assay
- Letter to the Editor(1)
- Activation of MAP Kinases by Arsenic Compounds in Normal Human Keratinocytes(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Hepatotoxicity of Disinfection By-products, Haloacetic Acids and Haloacetones(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Study of Different Induced S9 Fractions in Ames Assay Using Amine Compounds (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Mutagenicity and Hepatotoxicity of Diphenyl Ether Herbicides (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- RELATIONSHIP BETWEEN TOXICITY AND CADMIUM ACCUMULATION IN RATS GIVEN LOW AMOUNTS OF CADMIUM CHLORIDE OR CADMIUM-POLLUTED RICE FOR 22 MONTHS
- CADMIUM ACCUMULATION IN RATS TREATED ORALLY WITH CADMIUM CHLORIDE FOR 8 MONTHS
- Determination of EDTA in Water Samples by SPE-Gas Chromatography/Mass Spectrometry
- Effects of coating materials and size of titanium dioxide particles on their cytotoxicity and penetration into the cellular membrane
- -0428-SERIAL ASSESSMENT OF DENERVATED BUT VIABLE MYOCARDIUM IN PATIENTS WITH MYOCARDIAL INFARCTION USING SIMULTANEOUS I-123-MIBG AND TlCl-201 MYOCARDIAL SPECT
- THE EVALUATION OF THE CORRELATION BETWEEN LOCATION AND SIZE OF MYOCARDIAL INFARCTION AND REGIONAL, GLOBAL CARDIAC FUNCTION IN THE 150 PATIENTS OF MYOCARDIAL INFARCTION : Ventricular Function in Ischemic Heart Disease I : PROCEEDINGS OF THE 44th ANNUAL SCI
- Development of a SYBR Green Real-time Polymerase Chain Reaction Assay for Quantitative Detection of Human N-methyl-D-aspartate Receptors Subtype 1 Splice Variants
- Activation of the Human Transient Receptor Potential Vanilloid Subtype 1 by Essential Oils
- Effects of Long-Term Ingestion of Cadmium-Polluted Rice or Low-Dose Cadmium-Supplemented Diet on the Endogenous Copper and Zinc Balance in Female Rats
- Determination of Dimethyl Fumarate and Other Fumaric and Maleic Acid Diesters in Desiccants and Consumer Products in Japan
- NONlNVASIVE IDENTIFICAITON OF HIGH-RISK CORONARY ARTERY DISEASE PATIENTS : THE ROLE OF REST-EXERCISE LVET AND TRANSIENT-PERSISTENT DEFECT : Ichemic Heart Disease (II) : 46th Annual Scientific Meeting, Japanese Circulation Society
- Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice
- Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice
- Teratogenicity of multi-wall carbon nanotube (MWCNT) in ICR mice
- Sub-acute oral toxicity study with fullerene C60 in rats
- Risk Assessment of Fenthion Oxide Derivatives in Aqueous Environment
- Response to Letter to the Editor(2)
- Survey of Primary Aromatic Amines Originating from Azo Dyes in Commercial Textile Products in Direct Contact with Skin and in Commercial Leather Products in Japan
- Analysis of Isothiazolinones and Other Preservatives in Gel-Products Used for Cooling in Japan