CADMIUM ACCUMULATION IN RATS TREATED ORALLY WITH CADMIUM CHLORIDE FOR 8 MONTHS
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概要
- 論文の詳細を見る
To investigate the accumulation pattern of cadmium(Cd)in the liver and kidney following Cd intake from diet, female SD rats were fed cadmium choride(CdCl_2)-contained diets(1.24 and 4.96ppm Cd)for 2 or 4 months. The other rats were fed CdCl_2-contained diets(8, 40, 200, and 600ppm Cd)for 2, 4 or 8 months. The control rats were given diet without Cd addition(lower than 0.01ppm Cd). The concentrations of Cd in the liver and kidney derived from all rats were determined. The concentrations of Cd in the liver and kidney increased depending on the dosage of Cd. The concentrations of Cd in the liver did not reach plateau level even in the 200 and 600ppm groups. On the other hand, the concentrations of Cd in the kidney in the 200 and 600ppm groups reached a plateau level, which was approximately 250 μg/g. In the 600ppm group, the concentrations of Cd in the kidney reached 250 μg/g at 2 months, but did not exceed that level at 4 months. In the 200ppm group, the concentrations of Cd in the kidney increased to nearly the level of 250 μg/g at 8 months. The ratio of the concentrations of Cd in the kidney versus liver decreased as the dosage of Cd increased, suggesting that a low dosage of Cd was distributed preferentially to the kidney, but a high dosage of Cd w distributed to the liver. The relation curves between total amounts of Cd intake and Cd levels in the kidney in the 2-, 4-, and 8-month groups showed a parabola. The curves were shifted in parallel in the direction of higher levels of ingested Cd in order of length of Cd exposure period. These results suggested that when Cd is ingested over a long time at low concentrations, the amount of Cd accumulation in the kidney is small even for equal amounts of total ingested Cd.
- 日本トキシコロジー学会の論文
- 1998-08-17
著者
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Mitsumori Kunitoshi
Toxicology Division Institute Of Environmental Toxicology
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Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
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MITSUMORI Kunitoshi
Division of Pathology, National Institute of Health Sciences
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Mitsumori Kunitoshi
杏林製薬研究センター
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Hayashi Yuzo
Department of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirogane, Minato-ku, Tokyo 108-0
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Hayashi Yuzo
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Hayashi Yuzo
Department Of Pharmaceutical Sciences Kitasato University
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Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
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MITSUMORI Kunitoshi
Institute of Environmental Toxicology
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Ando Masanori
Division of Environmental Chemistry, National Institute of Health Sciences
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Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
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SATOH Shin-ichi
Second Laboratory, Ina Research Inc.
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HIRATSUKA Hideaki
Mitsubishi Chemical Safety Institute Ltd.
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NAKAGAWA Jun-ichi
Division of Food Sanitation, The Tokyo Metropolitan Research Laboratory of Public Health
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NAKAGAWA Jun-ichi
Tokyo Metropolitan Research Laboratory Public Health
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SATO Shin-ichi
Ina Research Inc.
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Sato Shin-ichi
Second Laboratory Ina Research Inc.
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Hiratsuka Hideaki
Kashima Laboratory Of Mitsubishi Chemical Safety Institute Ltd.
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三森 国敏
Division Of Pathology National Institute Of Health Sciences
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Nakagawa Jun-ichi
Department Of Environmental Health And Toxicology Tokyo Metropolitan Institute Of Public Health
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Ando Masanori
Division Of Environmental Chemistry National Institute Of Health Science
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Mitsumori K
The Institute Of Environmental Toxicology:agrotox Inc.
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Hayashi Yuzo
Department Of Cardiology Kasugai Municipal Hospital
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Sato Shin-ichi
Ina Res. Inc.
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