The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice
スポンサーリンク
概要
- 論文の詳細を見る
To determine the threshold dose of dicyclanil (DC) that induces hepatocellular tumor-promoting effects associated with reactive oxygen species (ROS) generation via their metabolic pathways, partial hepatectomized ICR male mice were fed diets containing 0, 187.5, 375 or 750 ppm DC after an intraperitoneal injection of N-diethylnitrosamine (DEN) to initiate hepatocarcinogenesis. Immunohistochemically, the proliferating cell nuclear antigen (PCNA)-positive cell ratio was significantly increased in the DEN + 750 ppm DC group compared with the DEN alone group. However, significant increases in the number of γ-glutamyltranspeptidase (GGT)-positive cells and formation of microsomal ROS were not observed in the DEN + DC groups compared with the DEN alone group. Real-time polymerase chain reaction (RT-PCR) showed that the expression of Cyp1a1, Cyp1a2, and OGG1genes was significantly up-regulated in mice given diets containing 375 ppm DC or more, 187.5 ppm DC or more, and 750 ppm DC, respectively. These results suggest that the threshold dose of DC that induces ROS-mediated liver tumor promotion in mice is more than 750 ppm, although expression of the Cyp1a2 gene, which is related to ROS generation, was up-regulated in the liver of mice, even at a DC dose of 187.5 ppm.
- 2010-02-01
著者
-
JIN Meilan
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
DEWA Yasuaki
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
KAWAI Masaomi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
NISHIMURA Jihei
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
SAEGUSA Yukie
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
KEMMOCHI Sayaka
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
HARADA Tomoaki
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
-
Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Mitsumori Kunitoshi
東京大学医科学研究所 癌細胞シグナル分野
-
Mitsumori Kunitoshi
国立医薬品食品衛生研究所 病理部
-
Mitsumori K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
三森 国敏
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Dewa Yasuaki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Dewa Yasuaki
東京農工大学 獣医病理学
-
Maita K
The Institute Of Environmental Toxicology:agrotox Inc.
-
Mitsumori Kunitoshi
Department Of Pathology National Institute Of Health Sciences
-
Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
-
Jin Meilan
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Saegusa Yukie
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Kawai Masaomi
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Harada Tomoaki
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Shibutani Makoto
Division Of Pathology National Institute Of Health Sciences
-
Matsumoto K
Kyushu Univ. Fukuoka Jpn
-
Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
-
三森 国敏
Division Of Pathology National Institute Of Health Sciences
-
Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Nishimura Jihei
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Nishimura Jihei
Laboratory Of Applied Physiology Faculty Of Agriculture Kobe University Graduate School Of Science A
-
Kemmochi Sayaka
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
関連論文
- The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice
- A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
- Low dose effects of dichlorodiphenyltrichloroethane (DDT) on gene transcription and DNA methylation in the hypothalamus of young male rats : implication of hormesis-like effects
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Lack of Modifying Effects of Combined Treatment of t-butylhydroquinone and Sodium Nitrite on Forestomach Carcinogenesis in rasH2 Mice Initiated with N-ethyl-N-nitrosourea
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lack of Modifying Effects of 2,6-Dimethylaniline on Lung Carcinogenesis in Transgenic Mice Carrying Human Prototype c-Ha-ras Gene Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Difference in the Types of Uterine Tumors between Heterozygous p53-deficient and Wild Type CBA Mice Treated with Ethinylestradiol after N-ethyl-N-nitrosourea Initiation
- Modifying effect of atrazine on DMBA-induced mammary carcinogenesis in ovariectomized rats.(GENERAL SESSION BY POSTER PRESENTATION)(CARCINOGENICITY)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Crosstalk between PTEN/Akt2 and TGFβ signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model
- A Case Report of a Cerebellar Neuroblastoma in a p53 Null Mutation Mouse(Pathology)
- Suppressive effect of Siraitia grosvenorii extract on dicyclanil-promoted hepatocellular proliferative lesions in male mice
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Modifying effect of Siraitia grosvenori extract on piperonyl butoxide-promoted hepatocarcinogenesis in rats
- Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats
- Reactive Oxygen Species Are Possibly Involved in the Mechanism of Flumequine-Induced Hepatocarcinogenesis in Mice
- Molecular Analysis on the Possible Mechanism of β-Naphthoflavone-Induced Hepatocarcinogenesis in Rats
- Molecular Pathological Analysis of Apoptosis Induced in Testicular Germ Cells after a Single Administration of Mono-(2-ethylhexyl) phthalate to F344 Rats
- The expression of Ras-related molecules in DMBA-induced forestomach tumors in rasH2 mice(Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In vitro genotoxic potential and liver initiation activity of ciprofloxacin(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- Induction of Hepatocellular Proliferative Lesions in CBA Mice by a 26-week Dietary Administration of Kojic Acid
- Absence of DNA Damage in Comet Assay and Liver Initiation Activity of Cinnamaldehyde
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene
- Enhancing Effects β-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
- GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- O-16 Analysis of gene expression profiles of forestomach tumors in rasH2 mice initiated with N-ethyl-N-nitrosourea(ENDOCRINE SYSTEM/DEVELOPMENT AND REPRODUCTION/CARCINOGENICITY/TOXICOGENOMICS)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Analysis of Gene Expression Profile on Uterine Tumorigenesis Initiated with N-ethyl-N-nitrosourea and Inhibited by Ethinylestradiol in rasH2 Mice
- THIRTEEN-WEEK REPEATED DOSE TOXICITY OF RICE BRAN GLYCOSPHINGOLIPID IN WISTAR HANNOVER (GALAS) RATS
- THIRTEEN-WEEK REPEATED DOSE TOXICITY STUDY OF WORMWOOD (ARTEMISIA ABSINTHIUM) EXTRACT IN RATS
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Investigation on liver initiation activity and DNA damages of flumequine in mice.(GENERAL SESSION BY ORAL PRESENTATION)(CARCINOGENICITY)
- A case report of a renal mixed epithelial and stromal tumor in a heterozygous S1P2 receptor deficient mouse
- Optimization of Enhancement of Therapeutic Efficacy of Ultrasound : Frequency-Dependent Effects on Iodine Formation from KI-Starch Solutions and Ultrasound-Induced Killing of Rat Thymocytes
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- A Case Report of an Uncommon Sex-Cord Stromal Tumor consisted of Luteal and Sertoli Cells in a Spayed Bitch
- Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
- O-13 Genotoxic potential in vitro and liver initiation activity of norfloxacin(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- O-12 Molecular pathological analyses on hepatocarcinogenesis induced by dicyclanil in mouse two-stage liver carcinogenesis model(CARCINOGENICITY)(GENERAL SESSION BY ORAL PRESENTATION)(Proceedings of the 31st Annual Meeting)
- MULTIPLICITY OF SPONTANEOUS LUNG TUMORS IN CD-1 MICE
- SPONTANEOUS TUMORS IN F344/DuCrj RATS FROM 12 CONTROL GROUPS OF CHRONIC AND ONCOGENICITY STUDIES
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN MICE
- 24-MONTH CHRONIC TOXICITY STUDY WITH GUAZATINE IN RATS
- RENAL TUMOR INDUCED BY METHYLMERCURY CHLORIDE IN ICR MICE
- SUBACUTE TOXICITY STUDIES WITH ZNSO_4 IN RATS AND MICE (The 6th Meeting for the Study of Toxic Effect)
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH METHYL MERCURY CHLORIDE IN RATS (The 5th Meeting for the Study of Toxic Effect)
- Time Course of Expression of 7,12-Dimethylbenz[a]anthracene-induced CYP1A1 and CYP1B1 mRNA and Protein in Rat Liver
- THIRTY-MONTH CHRONIC TOXICITY STUDIES WITH ZINC ETHYLENE BISDITHIOCARBAMATE (ZINEB) IN RATS (The 6th Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN RATS (The Fourth Meeting for the Study of Toxic Effect)
- TWENTY-FOUR-MONTH CHRONIC TOXICITY STUDIES WITH DICHLORODIISOPROPYLETHER (DCIP) IN MICE (The Fourth Meeting for the Study of Toxic Effect)
- 214. CHRONIC TOXICITY STUDIES IN RATS WITH METHYL MERCURY CHLORIDE (The Third Meeting for the Study of Toxic Effect)
- ABSENCE OF IN VIVO GENOTOXICITY AND LIVER INITIATION ACTIVITY OF DICYCLANIL
- Ultrastructural Morphology of Motor Endplate Neurotoxicities in Rats
- 6例のF344ラットの耳介に発生した無色素性黒色腫〔英文〕
- THIRTEEN-WEEK SUBACUTE TOXICITY STUDY OF 4-BROMOPHENYL CHLOROMETHYL SULFONE (BCS) IN RATS
- SPONTANEOUS RADICULONEUROPATHY IN AGING RATS
- TWENTY FOUR-MONTH CHRONIC TOXICITY STUDY WITH BIS (DIMETHYLTHIOCARBAMOYL) DISULFIDE (THIRAM) IN BEAGLES
- DELAYED NEUROTOXICITY STUDIES IN JAPANESE QUAIL (The 6th Meeting for the Study of Toxic Effect)
- The Influence of Pre- and Post-natal Exposure to Methoxychlor on the Immune System and Renal Function of Sprague-Dawley Rats
- Age-Related Hematological Changes in Normal F344 Rats: during the Neonatal Period
- Point Mutations of the c-H-ras Gene in Spontaneous Pulmonary Tumors of Transgenic Mice Carrying the Human c-H-ras Gene
- Immunohistochemical demonstration of ornithine decarboxylase (ODC) expression in altered liver cell foci of rats treated with peroxisome proliferators.
- Evaluation of carcinogenicity on chemicals using transgenic mice
- Alterations in the Developing Immune System of the Rat after Perinatal Exposure to Methoxychlor
- P11-10 Kidney damages induced by tetrabromobisphenol A in newborn rats
- B25 HEPATOTOXICITY OF TOCP IN RATS
- EFFECTS OF CONTINUOUS ALCOHOL INGESTION ON LOCOMOTOR ACTIVITY AND EATING BEHAVIOR
- EFFECTS OF ALCOHOL ON SUBACUTE TOXICITY OF PESTICIDES
- Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma
- Lack of Modifying Effect of Arctiin on ENU-Induced Uterine Carcinogenesis in ICR Mice
- Cytokeratin 8/18 Is a Useful Immunohistochemical Marker for Hepatocellular Proliferative Lesions in Mice
- Classification of Renal Proliferative Lesions in Rats and/or Mice and Their Diagnostic Problems : Report from the Working Group of the Japanese Society of Toxicologic Pathology
- POSSIBLE MECHANISM ON ENHANCED CARCINOGENESIS OF GENOTOXIC CARCINOGENS AND UNSOLVED MECHANISMS ON LESSER CARCINOGENIC SUSCEPTIBILITY TO SOME CARCINOGENS IN RASH2 MICE
- Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model
- A Neuroendocrine Carcinoma of Undetermined Origin in a Dog
- No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
- Gene Expression Profiling and Cellular Distribution of Molecules with Altered Expression in the Hippocampal CA1 Region after Developmental Exposure to Anti-Thyroid Agents in Rats
- Preparation and Characterization of Liposomal Microencapsulated Poly-γ-glutamic Acid for Prevention of Ca-Phosphate Precipitation under Intestinal Environment
- Preventive Effects of Calcitriol on the Development of Capsular Invasive Carcinomas in a Rat Two-Stage Thyroid Carcinogenesis Model
- Spontaneous Renal Mixed Epithelial and Stromal Tumor (MEST) in a Beagle
- Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
- Threshold dose of liver tumor promoting effect of β-naphthoflavone in rats
- Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action
- Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats
- Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats
- A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
- No Modifying Effect of Antioxidant N-Acetyl-L-Cysteine on Fenofibrate-induced Hepatocarcinogenesis in Rats
- A Case Report of a Renal Mixed Epithelial and Stromal Tumor in a Heterozygous S1P2 Receptor Deficient Mouse(Pathology)
- Induction of ovarian toxicity in a subchronic oral toxicity study of citrinin in female BALB/c mice