A Mixed Apocrine Gland Tumor with Metastases to the Bone and Bone Marrow in a Miniature Poodle
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概要
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A 10-year-old female miniature poodle had a mass in its carpal joint of the left forelimb. The tumor was divided into small multiple lobules by delicate connective tissues, and necroses were found in some of the central lobules. In some connective stromal areas, chondroid and osteoid tissues were formed. The tumor cells were similar to the structure of apocrine gland epithelial cells with apical blebs resembling apocrine secretion and eosinophilic secretary materials within the luminal space, and spindle cells were sometimes found in the basal area of the glandular structure. In some areas, tumor cells invaded in the blood vessels, bone and bone marrow. Immunohistochemically, the tumor cells forming tubulo-acinar to solid structures were intensely positive for cytokeratin and keratin K8/K18, and the spindle cells were positive for vimentin and alpha-smooth muscle actin. This case was diagnosed as a malignant mixed apocrine gland tumor with metastases to the bone and bone marrow.
著者
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SHIBUTANI Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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MITSUMORI Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Morita Reiko
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Jin Meilan
Division Pathology, Biological Safety Research Center, National Institute of Health Sciences
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Ogawa Bun-ichiro
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Kuwata Kazunori
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
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Mitsumori Kunitoshi
Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec
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Shibutani Makoto
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
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