Lack of Modifying Effect of Arctiin on ENU-Induced Uterine Carcinogenesis in ICR Mice

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概要

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• The present study was performed to investigate the modifying effects of arctiin, a plant lignan isolated from Arctium lappa (burdock) seeds, on uterine carcinogenesis induced by N-ethyl-N-nitrosourea (ENU) initiation in mice. Female ICR mice aged 5 weeks were administered a single intra-uterine injection of ENU at a dose of 50 mg/kg via the vagina. After 1 week, the animals were fed a soybean-free diet containing 0 (control), 0.004, 0.02 and 0.1% of arctiin for 26 weeks. Histopathological examinations revealed the development of uterine proliferative lesions such as adenocarcinoma, atypical hyperplasia, adenomyosis, and endometrial hyperplasia. However, there were no significant differences in the incidences and severities of these lesions among the groups. These results indicate that arctiin showed no definite modifying effects on uterine carcinogenesis under the present experimental conditions.

• 日本毒性病理学会の論文
• 2007-09-30

著者

• MITSUMORI Kunitoshi

  Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology

• TAMURA Toru

  Division of Pathology, National Institute of Health Sciences

• Tamura Toru

  キッセイ薬品工業中央研究所

• Tamura Toru

  Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.

• Tamura Toru

  信州大学 大学院総合工学系研究科

• KURODA Junji

  Toxicology Laboratory, Kissei Pharmaceutical Co., Ltd.

• SHIBATA Nobuo

  Research and Development Division, Kissei Pharmaceutical Co. Ltd.

• SHIBATA Nobuo

  Toxicology Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd.

• Mitsumori Kunitoshi

  Laboratory Of Veterinary Pathology Division Of Animal Science Institute Of Symbiotic Science And Tec

• Okuhara Yuji

  Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.

• Hayashi Morimichi

  Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.

• Nagasawa Tatsuya

  Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.

• Hayashi Morimichi

  Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.

• Okuhara Yuji

  Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.

• Kuroda Junji

  Toxicology Lab. Kissei Pharmaceutical Co. Ltd.

• Kuroda J

  Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.

• Kuroda Junji

  Toxicology

• Nagasawa Tatsuya

  Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.

• KITAMURA Tsuyoshi

  Toxicology Laboratories, Research and Development, Kissei Pharmaceutical Co. Ltd.

• Hayashi Morimichi

  Toxicology Laboratories Research And Development Kissei Pharmaceutical Co. Ltd.

• Shibata Nobuo

  Research And Development Division Kissei Pharmaceutical Co. Ltd.

• Shibata Nobuo

  Toxicology Research Laboratory Kissei Pharmaceutical Co. Ltd.

• Shibata Nobuo

  Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.

• Kitamura Tsuyoshi

  Toxicology Laboratories Research And Development Kissei Pharmaceutical Co. Ltd.

• Tamura Toru

  Div. Of Pathology Nihs

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