Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat
スポンサーリンク
概要
- 論文の詳細を見る
A subcutaneous mass was noted in the abdomen of a 50-week-old male Wistar Hannover GALAS rat. Histologically, the tumor was composed of vimentin-positive small round cells with scant cytoplasm arranged in a trabecular, sheet or pericytoma-like pattern and spindle cells arranged in a bundle pattern and vimentin-negative round cells proliferating in an island-shaped pattern. Argentophilic thin fibers were observed to wrap up the individual cells, and some of the tumor cells showed coexpression of vimentin and cytokeratin that formed juxtanuclear globes in the cytoplasm by double immunohistostaining. Transmission electron microscopy did not reveal any characteristic features suggesting cellular differention toward a specific cell type. Based on these findings, it was difficult to specify the origin, and the tumor was diagnosed as a poorly differentiated mesenchymal tumor and classified as a sarcoma, NOS (not otherwise specified).
著者
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Tamura Toru
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Onozato Tomoya
Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.
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Okuhara Yuji
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology
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Nagasawa Tatsuya
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Hayashi Morimichi
Toxicology Laboratories Research And Development Kissei Pharmaceutical Co. Ltd.
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Tamura Toru
Toxicology Research Laboratory, R, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan
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Hayashi Morimichi
Toxicology Research Laboratory, R, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan
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Kuroda Junji
Toxicology Research Laboratory, R, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan
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Okuhara Yuji
Toxicology Research Laboratory, R, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan
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Nagasawa Tatsuya
Toxicology Research Laboratory, R, Kissei Pharmaceutical Co., Ltd., 2320-1 Maki, Hotaka, Azumino, Nagano 399-8305, Japan
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- Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat
- Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat
- Spontaneous Subcutaneous Sarcoma in a 50-week-old Male Wistar Hannover GALAS Rat
- A TIME-COURSE CHARACTERIZATION OF MALE REPRODUCTIVE TOXICITY IN RATS TREATED WITH METHYL METHANESULPHONATE (MMS)