A TIME-COURSE CHARACTERIZATION OF MALE REPRODUCTIVE TOXICITY IN RATS TREATED WITH METHYL METHANESULPHONATE (MMS)
スポンサーリンク
概要
- 論文の詳細を見る
Methyl methanesulphonate (MMS), a potent alkylating agent and testicular toxicant, was orally administered to rats for 5 days at doses of 20, 30, and 40mg/kg. During the recovery period of 5 weeks, males were evaluated for multiple endpoints such as organ weights, fertility, and sperm parameters. The 5-week recovery periods are designated as follows : Day 1 (1 day after final treatment); Week 1, Week 2, Week 3, Week 4, and Week 5 (first, second, third, fourth, and fifth week after final treatment). A clear time-course of dominant lethals was observed. The peak severities of the dominant lethals were observed in Week 2. It was judged that the most sensitive cellular targets for the dominant lethals are late spermatids. Sperm examination revealed a clear time-course and dose-dependent changes in the frequency of sperm morphological abnormalities. The peak severities of the sperm morphological alterations in cauda epididymis were observed in Week 4. Sensitive cellular stages for the induction of sperm morphological abnormalities were judged to be late spermatocytes and early spermatids. The most frequently observed type of morphologically abnormal spermatozoa was tailless sperm, followed by no-hook head sperm. Although the initial cause for both sperm morphological alterations and dominant lethals was suggested to be genetic insult to the germ cells, there were no obvious relationships observed between these two findings.
- 日本トキシコロジー学会の論文
- 2005-05-25
著者
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SUDA Satoshi
Toxicology Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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Hayashi Morimichi
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Yokoi Ryohei
Toxicology Research Laboratory R & D Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology Lab. Kissei Pharmaceutical Co. Ltd.
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Kuroda J
Toxicology Research Laboratory R&d Kissei Pharmaceutical Co. Ltd.
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Kuroda Junji
Toxicology
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OZAWA Shigenari
Toxicology research laboratories, Kissei Pharmaceutical Co., Ltd.
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Kuriyama Kazuya
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Ozawa Shigenari
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Ozawa S
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
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Kobayashi Kazuo
Pharmacodynamics Research Laboratories Sankyo Co. Ltd.
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Kobayashi Kazuo
Toxicology Research Laboratory, R & D, Kissei Pharmaceutical Co., Ltd.
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Suda S
Toxicology research laboratories, Kissei Pharmaceutical Co., Ltd.
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Hayashi M
Toxicology research laboratories, Kissei Pharmaceutical Co., Ltd.
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Tsujii H
Faculty of Agriculture, Shinshu University
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YOKOI Ryohei
Toxicology Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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KOBAYASHI Kazuo
Toxicology Research Laboratories, Kissei Pharmaceutical Co., Ltd.
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