TISSUE-DEPENDENT INDUCTION OF HEME OXYGENASE-1 AND METALLOTHIONEIN-1/2 BY METHYL METHANESULFONATE
スポンサーリンク
概要
- 論文の詳細を見る
Methyl methanesulfonate (MMS), a methylating agent, is known to be a genotoxicant in testis. The purpose of this study was to investigate roles of oxidative stress-responsive proteins, heme oxygenase-1 (HO-1) and metallothionein-1/2 (MT-1/2), in genotoxicity of MMS. Cadmium, a potent genotoxicity inducer, induced HO-1 and MT-1/2 in rat livers and kidneys. Then we comparatively investigated MMS-induced HO-1 and MT-1/2 in rat livers, kidneys and testes. We found that a single administration of MMS (40 mg/kg) resulted in the induction of MT-1/2 mRNA in the liver, but not HO-1 mRNA, reaching maximum level at 6 hr and returning to the control levels by 24 hr. Interestingly, MMS induced both HO-1 and MT-1/2 mRNAs in the kidney. In contrast, MMS induced HO-1 mRNA, but not MT-1/2 mRNA in the testis. Since HO-1 and MT-1/2 have been recognized to respond to various oxidative stimuli, we further examined the inducing effect of MMS on these two proteins. MMS at dosages of 20 to 40 mg/kg for 2 consecutive weeks induced HO-1 mRNA (123 to 187% of the control) and protein (274 to 404% of the control) in rat testes. However, MT-1/2 mRNA was not induced by MMS administration, although a high level of expression was observed in comparison with the liver and kidney. These findings suggest that MMS induces HO-1 and/or MT-1/2 mRNA and its protein tissue-dependently, and the heme catabolites by HO-1 in the testis may contribute in some manner to its genotoxicity.
- 日本トキシコロジー学会の論文
- 2003-08-29
著者
-
NUMAZAWA Satoshi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
-
YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
-
Yoshida Takemi
Dep. Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa Univ.
-
Yoshida T
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
ASHINO TAKASHI
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
-
Numazawa Satoshi
Dep. Of Biochemical Toxicology School Of Pharmacy Showa Univ.
-
Numazawa Satoshi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Numazawa Satoshi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
-
Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
-
Ashino Takashi
Dept. Biochem. Toxicol. Sch. Pharmaceut. Sci. Showa University
-
OZAWA Shigenari
Toxicology research laboratories, Kissei Pharmaceutical Co., Ltd.
-
Ozawa Shigenari
Toxicology Research Laboratory Kissei Pharmaceutical Co. Ltd.
-
Ozawa Shigenari
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
-
Yoshida Takemi
昭和大学 薬学部毒物学
-
Ozawa S
Toxicology Research Laboratories Kissei Pharmaceutical Co. Ltd.
-
Ozawa Shigenari
Toxicology Laboratories R&d Kissei Pharmaceutical Co. Ltd.
-
Numazawa Satoshi
Dept. Biochem. Toxicol. Sch. Pharmaceut. Sci. Showa University
-
Yoshida Takemi
Dept. Biochem. Toxicol. Sch. Pharmaceut. Sci. Showa Univ.
-
Ashino Takashi
Dept. Biochem. Toxicol. Sch. Pharmaceut. Sci. Showa Univ.
-
Ashino Takashi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
関連論文
- Recreational drugs, 3,4-Methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite outgrowth in PC12 cells
- Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages
- Salbutamol inhibits lipopolysaccharide-induced inflammatory responses in rat peritoneal macrophages
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- Detection of Bisphenol-A in Dental Materials by Gas Chromatography-Mass Spectrometry
- P6-08 Possible role of inflammatory cytokine in liver injury caused by cocaine(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Possible role of inflammatory cytokines in liver injury caused by cocaine (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Change of oxidative stress responsive protein and cytochrome P450 in Rheumatoid arthritis model mouse.(GENERAL SESSION BY ORAL PRESENTATION)(IMMUNE AND ALLERGIC SYSTEM)
- O11-04 A role of inflammatory cytokine in CYP down-regulation caused by BCG or LPS
- Intermediate Valence State of La_Eu_Ni_2(Si_Ge_x)_2 Compounds (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- TISSUE- AND DOSE-DEPENDENT ALTERATION OF STRESS-INDUCIBLE PROTEINS BY β_2-ADRENOCEPTOR AGONIST, SALBUTAMOL, IN RATS
- QUANTITATIVE ESTIMATION OF MYOCARDIAL FIBROSIS BASED ON RECEPTOR OCCUPANCY FOR β_2-ADRENERGIC RECEPTOR AGONISTS IN RATS
- Establishment and Peculiarity of Ouabain-resistant THP-1 cells
- COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
- ALTERATIONS OF HEPATIC MITOCHONDRIAL MONOAMINE OXIDASE ACTIVITY OF RATS DURING 2-ACETYLAMINOFLUORENE FEEDING
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- P12-08 Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-metabolizing Enzymes In Vivo and In Vitro
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- O-24 HEME OXYGENASE GENE EXPRESSION BY LIPOPOLYSACCHARIDE IN IL-1 ALPHA/BETA KNOCK OUT MOUSE.(Proceedings of the 27th Annual Meeting)
- 22C-11-1 Allergic Contact Dermatitis in IL-1 α/β Doubly Deficient Mice.
- Relationship between Various Obesity Indices and Brachial-Ankle Pulse Wave Velocity According to Age among Japanese Females
- INTEGRATED NMR-BASED METABONOMIC INVESTIGATION OF EARLY METABOLIC EFFECTS OF ETHYLENE GLYCOL MONOMETHYL ETHER (EGME) ON MALE REPRODUCTIVE ORGANS IN RATS
- A TIME-COURSE CHARACTERIZATION OF MALE REPRODUCTIVE TOXICITY IN RATS TREATED WITH METHYL METHANESULPHONATE (MMS)
- P-93 Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeaated Dose Studeis in Rats. : 13)Two-week and 4-Week Administration Studies of Methyl Methanesulfonate (MMS).(Proceedings of the 27th Annual Meeting)
- COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 15)TWO-WEEK AND 4-WEEK ADMINISTRATION STUDY OF METHYL METHANESULFONATE(MMS)
- Induction of oxidative stress responsive proteines by methyl methanesulfonate, which produces reproductive toxicity (DEVELOPMENT AND REPRODUCTION) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- TISSUE-DEPENDENT INDUCTION OF HEME OXYGENASE-1 AND METALLOTHIONEIN-1/2 BY METHYL METHANESULFONATE
- COMPARISON OF SPERM MOTILITY TEST METHODS(EXCEPT COMPUTER-ASSISTED SPERM ANALYSIS)IN RATS UNDER THE CONDITION OF ALFA-CHLOROHYDRIN TREATMENT : COLLABORATIVE INVESTIGATION
- Micronucleus test in rats after oral administration of methyl methanesulfonate for 4 weeks
- STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
- Bisphenol-A contents in materials used in pediatric dentistry
- Regulation of ERK-Mediated Signal Transduction by p38 MAP Kinase in Human Monocytic THP-1 Cells
- INDUCTION OF HEPATIC CYP2B1/2 BY A TERATOGENIC COMPOUND cis-1-[-4-P-MENTHANE-8-YLOXY)PHENYL]PIPERADINE(YM9429)IN RATS
- Mechanism of Heme Oxygenase-1 (HO-1) Induction by a Glutathione Depletor, Phorone in Rar Livers
- Selective Inhibition of Chondrogenic Differentiation in Embryonic Cells by a Teratogenic Compound
- "B-10 MECHANISM OF HEME OXYGENASE-1 (HO-1) INDUCTION UNDER OXIDATIVE STRESS EVOKED BY A GLUTATHIONE DEPLETOR, PHORONE, IN RAT LIVERS.
- Possible Role of Glutathione Depletion in the Induction of Rate-Limiting Enzymes Involved in Heme Degradation and Polyamine Biosynthesis in the Liver of Rats
- Comparative Studies on the Inducing Effects of Cobalt Chloride and Co-Protoporphyrin on Hepatic Ornithine Decarboxylase and Heme Oxygenase in Rats
- DEPLETION OF HEPATIC GLUTATHIONE IS FOLLOWED BY THE INDUCTION OF HEME OXYGENASE AND CHANGES IN DRUG-METABOLIZING ENZYMES
- Relationship between Hepatic Glutathione Consumption and the Induction of Enzymes Involved in Polyamine Biosynthesis Evoked by Various Drugs and Chemicals (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- EVALUATION OF THE INDUCTION OF HEPATIC DRUG-METABOLIZING ENZYMES IN THE RAT AND MOUSE TREATED WITH TEMAZEPAM USING TRIMETHADIONE AS THE INDICATOR
- RELATIONSHIP BETWEEN TRIMETHADIONE METABOLISM AND HEPATIC DRUG-OXIDIZING ENZYME ACTIVITIES IN DIFFERENT ANIMAL SPECIES
- STUDIES ON THE TRIMETHADIONE METABOLISM AS A TOOL FOR THE ASSESSMENT OF DRUG-METABOLIZING CAPACITY USING PLASMA AND URINE OF RATS PRETREATED WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE
- DETERMINATION OF PLASMA TRIMETHADIONE AND ITS METABOLITE IN CARBON TETRACHLORIDE-INTOXICATED RATLIVER : A USEFUL TOOL FOR ESTIMATION OF HEPATIC DRUGMETABOLIZING CAPACITY
- SALIVA LEVELS OF TRIMETHADIONE AND ITS METABOLITE AS AN INDEX OF DRUG METABOLIZING ACTIVITY IN RATS
- Crystal structures of betaine phosphate/Arsenate mixed crystal
- Crystal structure and phase transition at low temperature in betaine phosphate
- XAFS Study on the Structure of Ytterbium(III)Trifluoromethanesulfonates as a New Type Catalyst (Proceedings of the Second International Conference on SRMS(Synchrotron Radiation in Materials Science)(2))
- INDUCTION OF HEME OXYGENASE AND INHIBITION OF δ-AMINOLEVULINIC ACID SYNTHETASE OF RAT LIVER BY THIOACETAMIDE AND THIOACETAMIDE-S-OXIDE
- P6-07 Protection against cocaine-induced liver injury by auranofin(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Tests : with Special Reference to Alterenative Sensitization Test
- Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Sensitization Tests
- S12-5 Oxidative stress response mechanisma as defenses from toxic insults(SYMPOSIUM 12: OXIDATIVE STRESS AND ORGAN DAMAGE)(Proceedings of the 31st Annual Meeting)
- SIMULTANEOUS INDUCTION OF ORNITHINE DECARBOXYLASE AND HEME OXYGENASE UNDER VARIOUS EXPERIMENTAL CONDITIONS
- The Mode of Induction of Ornithine Decarboxylase by Heavy Metals (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Metallothionein Synthesis Induced by Interferon α/β in Mice of Various Zinc Status
- Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities
- Determination of muscimol and ibotenic acid in Amanita mushrooms by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry
- Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications
- POTENTIATION OF AFLATOXIN B_1 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS WITH ETHANOL PRETREATMENT
- AN INDUCTION OF HEME OXYGENASE AND ITS POSSIBLE RELATION TO THE DECREASE OF CYTOCHROME P-450 CONTENT DURING LIVER REGENERATION
- ALTERATIONS OF DRUG AND HEME METABOLIZING ENZYMES DURING LIVER REGENERATION
- EFFECT OF HEAVY METALS ON SOME ENZYMES OF RAT LIVER AND FACTORS WHICH MODIFY THE METAL ACTIONS, ESPECIALLY OF CADMIUM
- Interleukin-1 Controls the Constitutive Expression of the Cyp7a1 Gene by Regulating the Expression of Cyp7a1 Transcriptional Regulators in the Mouse Liver
- The mechanism of induction of HO-1 gene transactivation by 4-HNE.(GENERAL SESSION BY POSTER PRESENTATION)(ACTIVE OXYGEN ETC)
- O-56 Involvement of aPKC in Oxidative Stress-induced Heme Oxygenase-1.(Proceedings of the 27th Annual Meeting)
- Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
- Induction of Ornithine Decarboxylase by Heavy Metals : With Special Reference to Cadmium (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- ANALYSIS OF THE EXPRESSION OF HEME OXYGENASE-1 GENE IN HUMAN ALVEOLAR EPITHELIAL CELLS EXPOSED TO CIGARETTE SMOKE CONDENSATE
- Nrf2-DEPENDENT GENE EXPRESSIONS : A MOLECULAR TOXICOLOGICAL ASPECT
- Biological Surveillance and Defense Mechanism for Drug Toxicity and Its Breakdown(SYMPOSIUM 1 : MECHANISMS OF HEPATOTOXIC EFFECTS)
- Regulation of ERK-Mediated Signal Transduction by p38 MAP Kinase in Human Monocytic THP-1 Cells
- Comparison of in vitro metabolic conversion of capecitabine to 5-FU in rats, mice, monkeys and humans - toxicological implications
- TRIMETHADIONE AS A MODEL DRUG FOR THE EVALUATION OF HEPATIC DRUG-METABOLIZING CAPACITY IN NORMAL AND D-GALACTOSAMINE INTOXICATED RATS
- MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion
- Effects of Cabbage Leaf Protein Concentrate on the Serum and Liver Lipid Concentrations in Rats
- Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1
- 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
- PRODUCTION OF TOLERANCE TO FENITROTHION I N MALE RATS
- Possible Involvement of Transient Receptor Potential Channels in Electrophile-Induced Insulin Secretion from RINm5F Cells
- Involvement of Interleukin-1 in Lead Nitrate-Induced Hypercholesterolemia in Mice
- A TIME-COURSE CHARACTERIZATION OF MALE REPRODUCTIVE TOXICITY IN RATS TREATED WITH METHYL METHANESULPHONATE (MMS)
- Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
- Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta