POTENTIATION OF AFLATOXIN B_1 INDUCED HEPATOTOXICITY IN MALE WISTAR RATS WITH ETHANOL PRETREATMENT

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概要

• 論文の詳細を見る

• The interaction of ethanol and aflatoxin B_1 (AFB_1)-induced hepatotoxicity was studied in male Wistar rats using the activity of plasma GOT and GPT, liver triglyceride and histopathologic changes of liver necrosis as indices. Pretreatment of four oral doses of ethanol (4.0 g/kg BW each) at 48, 45, 24 and 21 hrs prior to AFB_1 (0.5 to 2.0 mg/kg BW) single i.p. administration caused a significant increase in the activity of PGOT (6 folds) and PGPT (5 folds), liver triglycerides (2 folds) and severity of liver necrosis at 48 hrs after AFB_1 administration. Ethanol pretreatment potentiated AFB_1-induced hepatotoxicity by increasing MFO enzymes, aniline hydroxylase and P-nitroanisole-O-demethylase activity and lipid peroxidation, and decreasing in cytochrome b_5, epoxide hydrolase activity and hepatic glutathione content. However, it did not cause any significant change in the activity of NADPH-cytochrome c reductase and glutathione-S-transferase and cytochrome P-450. These results suggest that potentiation of ethanol pretreatment on AFB_1-induced hepatotoxicity may due to an increase in the metabolic formation of AFB_1-2, 3-oxide and subsequent binding to DNA.

• 日本トキシコロジー学会の論文
• 1986-02-25

著者

• Kuroiwa Yukio

  Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University

• Yoshida T

  Department Of Physiology Faculty Of Science Mahidol University

• Yoshida Takemi

  Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University

• TOSKULKAO Chaivat

  Department of Physiology, Faculty of Science, Mahidol University

• GLINSUKON Thirayudh

  Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University

• Toskulkao C

  Mahidol Univ. Bangkok Thl

• Toskulkao Chaivat

  Department Of Physiology Faculty Of Science Mahidol University

• Glinsukon T

  Mahidol Univ. Bangkok Thl

• KUROIWA Yukio

  Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University

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