Hepatic Lipid Peroxidation and Intracellular Calcium Accumulation in Ethanol Potentiated Aflatoxin B_1 Toxicity
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概要
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The possible role of hepatic lipid peroxidation and Ca^<2+> in enhanced hepatotoxicity of aflatoxin B_1 (AFB_1) by ethanol was examined along with changes in hepatic glutathione in male rats. Hepatic glutathione (GSH) was markedly decreased (43.9%) at 12 h after AFB_1 administration in rats treated with ethanol (4.0 g/kg BW) and AFB_1 (2.0 mg/kg BW) when compared to AFB_1 alone. At 24 h after AFB_1 administration, hepatic lipid peroxide levels in subcellular fractions, particularly in microsomes, were significantly increased (76.9%) in rats treated with ethanol and AFB_1 following the decrease in hepatic GSH content. Hepatic lipid peroxide levels returned to normal values at about 48 h after AFB_1 administration. Furthermore, Ca^<2+> in whole liver (60.9%), microsomes (83.8%) and mitochondria (51.2%) were significantly increased in the rats treated with ethanol and AFB_1 as compared to those rats treated with AFB_1 alone at 48 h after toxin administration. The increase in hepatic Ca^<2+> in rats treated with ethanol and AFB_1 was a possible consequence of the increase in hepatic lipid peroxide. These findings suggest that there is a close relationship between hepatic GSH content, lipid peroxidation and intracellular accumulation of Ca^<2+>. The pronounced effects on hepatic lipid peroxidation and intracellular accumulation of Ca^<2+> could play a role in ethanol-induced potentiation of AFB_1 hepatotoxicity in rats.
- 公益社団法人日本薬学会の論文
著者
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GLINSUKON Thirayudh
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
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Toskulkao Chaivat
Department Of Physiology Faculty Of Science Mahidol University
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