PROTECTIVE EFFECTS OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON LIVER INJURY BY CARBON TETRACHLORIDE (CCl_4)
スポンサーリンク
概要
- 論文の詳細を見る
Effects of NKK-105 against lipid peroxidation of microsomes by CCl_4 are investigated, in vitro. NKK-105 had no effect on microsomal lipid peroxidation. When the microsomal fraction was preincubated with NKK-105 before adding CCl_4, the lipid peroxidation induced with CCl_4 was almost prevented by NKK-105. Effects of NKK-105 administration on aminopyrine N-demethylase, cyt.b_5, cyt.p-45O and lipid peroxidation in CCl_4-induced liver damage were investigated, in vivo. NKK-105 had no effect on the activity of aminopyrine N-demethylase and the content of cyt.b5, cyt.p-450 and peroxide. The content of cyt.b5, cyt.p-450 and the activity of demethylase remarkably decreased with CCl_4 administration, but the content of cyt. p-450 and the demethylase activity were restored about 75% of the control values and cyt.b5 content was completely restored with previous administration of NKK-105. The amount of peroxide in the microsomal fraction increased with CCl_4 administration was restored to the control level with previous administration of NKK-105.
- 日本トキシコロジー学会の論文
- 1982-02-25
著者
-
Egashira Toru
Department Of Cardiology Keio University School Of Medicine
-
Yamamoto T
Showa Univ. Tokyo Jpn
-
Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
-
Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
-
EGASHIRA TORU
Medical College of Oita
-
Kuroiwa Y
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
Yamamoto Toshinori
Department Of Pharmacology Medical College Of Oita
関連論文
- PE-436 Hydrogen Gas Protects Cardiomyocyte Cell Death and Reduces the Infarct Size in the Rat Model of Myocardial Ischemia-Reperfusion Injury(PE073,Myocardial Ischemia-reperfusion (Basic) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting o
- PE-452 Cardiomyocytes Derived from Bimaternal Parthenogenetic ES Cells by Epigenetic Modification have a Different Property and Genetic Presentation in Cardiogenesis(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the
- OE-251 Molecular Characterization, Safety and Feasibility of Induced Pluripotent Stem (iPS) Cell-derived Cardiomyocytes for Heart Regenerative Therapy(OE43,Regeneration (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- OE-251 Molecular Characterization, Safety and Feasibility of Induced Pluripotent Stem (iPS) Cell-derived Cardiomyocytes for Heart Regenerative Therapy(OE43,Regeneration (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- THE EFFECT OF INDOMETHACIN ON HEPATIC DRUG-OXIDIZING CAPACITY IN THE RAT : TRIMETHADIONE AND ANTIPYRINE METABOLISM AS AN INDICATOR
- A METHOD FOR ESTIMATION OF HEPATIC DRUG-METABOLIZING CAPACITY : DETERMINATION OF CONCENTRATION OF TRIMETHADIONE AND ITS METABOLITE IN HUMAN SERUM
- EVALUATION OF HUMAN HEPATOCYTE CHIMERIC MICE AS A MODEL FOR TOXICOLOGICAL INVESTIGATION USING PANOMIC APPROACHES : EFFECT OF ACETAMINOPHEN ON THE EXPRESSION PROFILES OF PROTEINS AND ENDOGENOUS METABOLITES IN LIVER, PLASMA AND URINE
- INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER : TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS
- IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM
- Investigation of protein expression induced by hepatotoxicants in rat hepatocytes cultures and livers(Proceedings of the 32nd Annual Meeting)
- Comparison between in vitro- and in vivo-hepatotoxicity for the investigation of a hepatotoxicity screening system in primary cell cultures(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH
- EFFECTS OF MALE REPRODUCTIVE TOXICANTS ON GENE EXPRESSION IN RAT TESTES
- PROTEIN EXPRESSION ANALYSIS OF RAT TESTES INDUCED TESTICULAR TOXICITY WITH SEVERAL REPRODUCTIVE TOXICANTS
- INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES : WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?
- Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro
- Stimulation of In Vitro Angiogenesis by Tetrahydrobiopterin in Bovine Aortic Endothelial Cells
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION III : EFFECT ON DOPAMINE β-HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- P7-24 Investigation of the hepato-toxicity screening system in primary cell culture(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-46 Effect of reproductive toxicants on the protein expression in the rat testis(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- P6-45 Effect of reproductive toxicants on the gene expression in the testes of rats(TOXICOGENOMICS)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- FLOW CYTOMETRIC DETECTION AND ANALYSIS OF TAILLESS SPERM CAUSED BY SONICATION OR A CHEMICAL AGENT
- 22A-09-3 Flow cytometric analysis (FCM) of sperms taken from rats treated with nitrobenzene (NB).
- EVALUATION OF RAT SPERM BY FLOW CYTOMETRY : SIMULTANEOUS ANALYSIS OF SPERM COUNT AND SPERM VIABILITY
- Scattering Observables of NN Interaction in the SU_6 Quark Model
- SELECTIVE EFFECT OF CHRONIC LEAD INGESTION ON TYROSINE HYDROXYLASE ACTIVITY IN BRAIN REGIONS OF RATS
- Human Organic Anion Transporters Mediate the Transport of Tetracycline
- PHARMACOKINETIC STUDIES OF TRIMETHADIONE AND ITS METABOLITE IN RATS WITH CHEMICAL-INDUCED LIVER INJURY
- A USEFUL MEASURE OF HEPATIC DRUG METABOLISM : TRIMETHADIONE ELIMINATION AS AN INDICATOR
- Establishment and Peculiarity of Ouabain-resistant THP-1 cells
- INITIAL METABOLISM OF GAMMA-HEXACHLOROCYCLOHEXANE (γ-HCH) BY RAT LIVER MICROSONES
- Nadph-dependent Lipid Peroxidation in the Liver Microsome of Rats Fed A 3′-Methyl-4-dimethyl-aminoazobenzene(3′-Me-DAB)-contaning Diet
- Effects of Cephem Antibiotics on Rat Liver Aldehyde Dehydrogenases
- COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
- PROTECTIVE EFFECTS OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENE MALONATE (NKK-105) ON LIVER INJURY BY CARBON TETRACHLORIDE (CCl_4)
- Inhibition of Monoamine Oxidase by 3′-Methyl-4-Dimethylamino Azobenzene (3′-Me-DAB) in Rat Liver Mitochondria
- ALTERATIONS OF HEPATIC MITOCHONDRIAL MONOAMINE OXIDASE ACTIVITY OF RATS DURING 2-ACETYLAMINOFLUORENE FEEDING
- Involvement of Adenosine A_2 Receptors in the Changes of Tissue Factor-Dependent Coagulant Activity Induced by Polymorphonuclear Leukocytes in Endothelial Cells
- Induction and Inhibition of Cytochrome P450 and Drug-Metabolizing Enzymes by Climbazole
- P12-08 Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-metabolizing Enzymes In Vivo and In Vitro
- CLIMBAZOLE IS A NEW POTENT INDUCER OF RAT HEPATIC CYTOCHROME P450
- Changes of Tissue Factor-Dependent Coagulant Activity Mediated by Adhesion Between Polymorphonuclear Leukocytes and Endothelial Cells
- Effect of 4-(4-Chlorobenzyl)pyridine on Rat Hepatic Microsomal Cytochrome P450 and Drug-Metabolizing Enzymes in Vivo and in Vitro
- SEX-RELATED EFFECT OF HEMIN ON CYTOCHROME P450 AND DRUG-METABOLIZING ENZYMES IN RAT LIVER
- Antigenic characterization in ampiroxicam-induced photosensitivity using an in vivo model of contact hypersensitivity
- Toxicomarker Discovery for Hepatotoxicity using Proteome Analysis Technology (TOXICOGENOMICS AND TOXICOPROTEOMICS) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Effects of KUR-1246, a selective uterine relaxant, on transplacental passage and transmigration to milk
- Ribosomal protein L3 mediated the transport of digoxin in Xenopus laevis oocyte
- Protective Effect of Ninjin-yoei-to on Damage to Isolated Hepatocytes Following Transient Exposure to tert-Butly Hydroperoxide
- Day/Night Variation of 5-Hydroxyindole Acetic Acid Concentration in Rat Cerebrospinal Fluid After Acute and Long-Term Administration of a Selective Serotonin Reuptake Inhibitor, Fluvoxamine
- The Inhibition of Monoamine Oxidase Activity by Various Antidepressants: Differences Found in Various Mammalian Species
- Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats
- Variation of Monoamines and Their Metabolite Contents in the Cerebrospinal Fluid of Conscious Rats
- "P-17 NO contribution to lipopolysaccharide-induced hepatic damage of galactosamine-sensitized mice.
- Effects of Bifemelane on Muscarinic Receptors and Choline Acetyltransferase in the Brains of Aged Rats Following Chronic Cerebral Hypoperfusion Induced by Permanent Occlusion of Bilateral Carotid Arteries
- Effect of Fluvoxamine on 5-Hydroxytryptamine Uptake, Paroxetine Binding Sites and Ketanserin Binding Sites in the Japanese Monkey Brain and Platelets, In Vivo and In Vitro
- Role of oxygen-derived free radicals and lipid peroxidation in blood induced by lipopolysaccharide(LPS).
- THE MULTIPLE HYDROPEROXIDES OF CHOLINE PHOSPHOLIPIDS OCCURRING IN PLASMA AFTER ISCHEMIA-REPERFUSION IN RAT LIVER
- Idenitification of phospholipid hydroperoxides in plasma of hepatic ischemiareperfused rats
- W-4 Investigation of the Other Organ Injury Caused by Liver Ischemia-Reperfusion
- MONOAMINE OXIDASE (MAO) IN PLASMA OF RATS AFTER HEPATOTOXINS ADMINISTRATION
- The Case for a Shift in Pharmacists' Activities and Pharmacy Education : Based on Those in The English Speaking Western Countries
- Pharmaceutical Terms Reflecting the Change in Practice in Japan
- Antioxidant and Hepatoprotective Actions of the Medicinal Herb Artemisia campestris from the Okinawa Islands
- ROLE OF PHOSPHATIDIC ACID IN CONTRACTILE MECHANISMS OF SMOOTH MUSCLE
- Mechanism of Salivary Secretion Enhancement by Byakkokaninjinto(Pharmacology)
- Inhibition by Zn^ of A-form Monoamine Oxidase in Monkey Brain Mitochondria
- Effect of Long-Term Fluvoxamine Treatment on Endogenous Serotonin Uptake Inhibitor-Like Substance in Monkey Cerebrospinal Fluid
- METHAMPHETAMINE-INDUCED BEHAVIORAL EFFECTS AND RELEASES OF BRAIN CATECHOLAMINES AND BRAIN CONCENTRATIONS OF METHAMPHETAMINE IN MICE
- EFFECTS OF CEPHEM ANTIBIOTICS ON RAT LIVER ALDEHYDE DEHYDROGENASES
- NADPH-DEPENDENT LIPID PEROXIDATION IN THE LIVER MICROSOME OF RATS FED A 3-METHYL-4-DIMETHYL-AMINOAZOBENZENE (3-Me-DAB)-CONTAINING DIET
- Effect of Methylprednisolone on Plasma Lipid Peroxidation Induced by Lipopolysaccharide
- SUPPRESSIVE EFFECT OF BIFEMELANE ON LIPID PEROXIDATION IN RAT LIVER
- NO CONTRIBUTION TO LIPOPOLYSACCHARIDE-INDUCED HEPATIC DAMAGE IN GALACTOSAMINE-SENSITIZED MICE
- EFFECTS OF ETHANOL ON CATECHOLAMINE LEVELS AND RELATED ENZYME ACTIVITIES IN DIFFERENT BRAIN REGIONS OF RATS
- FURTHER STUDIES ON THE SYNTHESIS OF A-FORM MONOAMINE OXIDASE
- INHIBITION OF MONOAMINE OXIDASE BY 3-METHYL-4-DIMETHYLAMINO AZOBENZENE (3-Me-DAB) IN RAT LIVER MITOCHONDRIA
- Concernment of Drug Consultation on Improvement in Patient's Knowledge by Pharmacist
- BINDING PROPERTIES OF HYDROPHILIC MUSCARINIC ANTAGONIST [^3H] NMeQNB IN THE SINGLE SMOOTH MUSCLE CELLS FROM GUINEA-PIG ILEUM
- EFFECT OF SODIUM NITRITE ON MONOAMINE OXIDASE ACTIVITY IN RAT LIVER AND BRAIN
- SYNTHETIC RATES OF MONOAMINE OXIDASE IN RAT LIVER AFTER CLORGYLINE OR DEPRENYL ADMINISTRATION
- B-8 An injury of the liver caused by ischemia-reperfusion in rat liver.
- EFFECTS OF PLURONIC F-127 ON LOADING OF FURA 2/AM INTO SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM GUINEA PIG TAENIA COLI
- Attenuation of Dysfunction in the Ischemia-Reperfused Liver by Glycyrrhizin
- Characteristics of Mitochondrial and Synaptosomal Monoamine Oxidase in Monkey Brain
- Some Interrelated Properties of A and B Form Monoamine Oxidase in Monkey Brain Mitochondria
- Functional characterization and substrate specificity of a novel gene encoding zinc finger-like protein, ZfLp, in Xenopus laevis oocytes
- PRODUCTION OF TOLERANCE TO FENITROTHION I N MALE RATS
- Three-dimensional echocardiography findings of biventricular thrombi complicated by cerebral embolism
- Efficacy and safety of short- and long-term treatment of itraconazole on chronic necrotizing pulmonary aspergillosis in multicenter study
- Application of Human iPS Cell-Technologies to Arrhythmia Researches
- Measurement of antifungal drug levels in cerebrospinal fluid for cryptococcal meningoencephalitis
- Novel Insights into Disease Modeling Using Induced Pluripotent Stem Cells
- Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
- Effects of d-methamphetamine on monkey brain monoamine oxidase, in vivo and in vitro.
- 18F-FDG-PET CT Findings in a Patient with Early-phase Cardiac Sarcoidosis
- Changes in amine oxidase in plasma of rats treated with hepatotoxins.
- Effect of bifemelane hydrochloride on an injury of the liver caused by ischemia-reperfusion in rats.
- Changes in MAO activities in several organs of rats after administration of l-thyroxine.
- Studies on monoamine oxidase. XVIII. Enzymic properties of placental monoamine oxidase.