INHIBITION OF MONOAMINE OXIDASE BY 3-METHYL-4-DIMETHYLAMINO AZOBENZENE (3-Me-DAB) IN RAT LIVER MITOCHONDRIA
スポンサーリンク
概要
- 論文の詳細を見る
Effects of 3-Me-DAB on MAO in rat liver mitochondria, <I>in vitro</I>, were investigated. 3-Me-DAB at a concentration of 1×10<SUP>-5</SUP> M inhibits MAO activity about 40%, and this inhibition recovered to the control value after dialysis overnight against 0.001 M phosphate buffer. MAO activity was inhibited in an apparently competitive fashion by 3-Me-DAB. These results indicate that 3-Me-DAB binds to mitochondrial MAO with a weak affinity <I>in vitro</I>. The K<SUB>m</SUB> value toward benzylamine was 220 μM using both the mitochondria from the liver of rats fed a basal diet and those from rats ingesting 3-Me-DAB. The activity of these enzyme preparations did not revert after dialysis to the control values of rats fed a basal diet. The titration experiment of MAO by pargyline suggests that the decrease of MAO activity, <I>in vitro</I>, is mainly due to the decrease of active MAO molecules in these mitochondrial preparations from livers of rats ingesting 3-Me-DAB.
- 社団法人 日本薬理学会の論文
著者
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Yamamoto T
Showa Univ. Tokyo Jpn
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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EGASHIRA TORU
Medical College of Oita
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Kuroiwa Y
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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KUROIWA Yukio
Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University
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