METHAMPHETAMINE-INDUCED BEHAVIORAL EFFECTS AND RELEASES OF BRAIN CATECHOLAMINES AND BRAIN CONCENTRATIONS OF METHAMPHETAMINE IN MICE

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The characteristic behavioral effect of methamphetamine (MA) at 2.5 mg/kg was enhanced locomotor activity which lasted over 2.5 hr. At 10.0 mg/kg MA, stereo-typed behavior was predominant and lasted over 3 hr. The behavioral effect of 5.0 mg/ kg MA was of the mixed type. MA at 5.0 and 10.0 mg/kg lowered the brain NE level from 2 hr after drug treatment, while the accumulation of MHPG-SO<SUB>4</SUB> was increased over 2 hr at 2.5 and 5.0 mg/kg MA. The accumulation of HVA was significantly increased at 10.0 mg/kg MA over 3 hr. Accordingly, the behavioral effects of MA at the earlier period were compatible with the biochemical effects of MA. The behavioral effects during the 2- to 4-hr period, however, seem to be unrelated to the actions on brain catecholamines. Measurement of brain MA concentrations revealed that approx. 2 μg/g in the brain may be necessary to produce enhanced locomotor activity and the increased accumulation of brain M H PG-SO<SUB>4</SUB>. It appeared that approx. 8 to 9 μg/g MA in the brain was required to produce characteristic stereotyped behavior and the increased accumulation of HVA. Therefore, the behavioral and biochemical effects of MA were correlated with the brain MA concentrations.
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