COMPARISON OF THE EFFECT OF AN EQUIMOLAR AND LOW DOSE OF FENITROTHION AND METHYLPARATHION ON THEIR OWN METABOLISM IN RAT LIVER
スポンサーリンク
概要
- 論文の詳細を見る
The effects of fenitrothion and methylparathion on the activities of cholinesterase and hepatic microsomal monooxygenases were investigated and Compared following a single or repeated oral administration of an equimolar and low dose of the insecticides. The activities of cholinesterase in brain and plasma were inhibited equally by the repetitive administration of both insecticides. Aminopyrine N-demethylase activity and cyt. P-450 content were not affected under the same experimental conditions. However, methylparathion, when given repeatedly, inhibited the dearylation and desulfuration of its own. The results may indicate that low dose continuous exposure to methylparathion could cause the depression of its own metabolism in rat.
- 日本トキシコロジー学会の論文
- 1982-02-25
著者
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YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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Egashira Toru
Department Of Cardiology Keio University School Of Medicine
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Yamamoto T
Showa Univ. Tokyo Jpn
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Yamamoto Toshinori
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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EGASHIRA TORU
Medical College of Oita
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Yoshida Takemi
School Of Pharmaceutical Sciences Showa University
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Kuroiwa Y
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Yamamoto Toshinori
Department Of Pharmacology Medical College Of Oita
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