STUDIES ON THE MECHANISM OF INTERACTION BETWEEN METHAMPHETAMINE AND QUININE IN RATS
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概要
- 論文の詳細を見る
Interactions between methamphetamine and quinine were studied using two different tests. The duration and intensity of methamphetamine-induced stereotyped behavior was enhanced by pretreatment of rats with quinine. Pretreatment of rats with SKF-525 A and CCl_4 also resulted in the enhancement of methamphetamine-induced stereotyped behavior. Pretreatment with phenobarbital shortened the stereotypy evoked by methamphetamine. Furthermore, urinary excretion patterns of methamphetamine and its metabolites were determined following the administration of the drug to rats which had been pretreated with certain drugs. Quinine, SKF-525 A and CCl_4 inhibited the urinary excretion of p-hydroxylated metabolites and increased the excretion of the unchanged methamphetamine and amphetamine. These results strongly suggest that the enhancement of methamphetamine-induced stereotyped behavior in the rats pretreated with quinine, SKF-525 A and CCl _4 could be ascribed to the inhibition of the p-hydroxylation reaction of methamphetamine and thus may lead to the increased concentration and pharmacological effect of the drug.
- 公益社団法人日本薬学会の論文
著者
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YOSHIDA Takemi
Department of Biochemical Toxicology, School of Pharmacy, Showa University
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KUROIWA YUKIO
Department of Biochemical Toxicology, School of Pharmaceutical Science Showa University
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SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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YANAURA Saizo
Department of Pharmacology, School of Pharmacy, Hoshi University
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Kuroiwa Yukio
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Kuroiwa Yukio
Department Of Biochemical Toxicology Faculty Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
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Yoshida Takemi
Department Of Biochemical Toxicology School Of Pharmaceutical Science Showa University
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Chiang Horng-jen
Department Of Pharmacology School Of Pharmacy Hoshi University
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Yanaura Saizo
Dept. Of Pharmacology School Of Pharmacy Hoshi University
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Yanaura Saizo
Department Of Pharmacology Hoshi College Of Pharmacy
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Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
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Suzuki Tsutomu
Dept. Of Pharmacology School Of Pharmacy Hoshi University
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Suzuki Tsutomu
星薬科大学 歯 薬理
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Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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CHIANG Horng-Jen
Department of Applied Pharmacology, School of Pharmacy, Hoshi University
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