Combined Effects of Psychostimulants and Morphine on Locomotor Activity in Mice
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概要
- 論文の詳細を見る
Simultaneous administration of psychostimulants and opioids is a major drug abuse problem worldwide. This combination appears to produce synergistic effects on behavior at low doses; however, there is little direct evidence that the combination is stronger than either drug alone. Therefore, we investigated interactions between psychostimulants and morphine on locomotor activity in mice. Low doses of cocaine (5.0 mg/kg) or methamphetamine (0.5 mg/kg) and morphine (10 mg/kg) enhance locomotor activity in a synergistic fashion. Effective doses of cocaine (20 mg/kg) and morphine (20 mg/kg) increased locomotion in an additive fashion. In contrast, combination of methamphetamine (1.0 and 2.0 mg/kg) and morphine (10 and 20 mg/kg) did not merely enhance their effects (or attenuated the peak effects of methamphetamine-induced hyperlocomotion). These results indicate that different mechanisms explain the interaction between morphine and methamphetamine or cocaine. It is well known that psychostimulants- and opioids-induced hyperlocomotion is mediated by the activation of the dopaminergic system, however, haloperidol (a dopamine receptor antagonist) and U50,488H (which attenuates dopamine release from nerve terminals) significantly increased the effects of methamphetamine and morphine on the locomotor activity. These results suggest that excess dopaminergic activation may be involved in the effects of methamphetamine and morphine on locomotor activity in mice.
- 社団法人 日本薬理学会の論文
- 2004-12-01
著者
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SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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Sawaguchi T
Department Of Emergency Medicine Tokyo Women's Medical University
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Ito Shinobu
Vitamin C60 Bioresearch Corporation
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Ito Shinobu
Department Of Legal Medicine Tokyo Women's Medical University
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NARITA Minoru
Department of Toxicology, School of Pharmacy, Hoshi University
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MORI Tomohisa
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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SAWAGUCHI Toshiko
Department of Legal Medicine, Tokyo Women's Medical University
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Suzuki Tsutomu
Department Of Emergency Medicine Tokyo Women's Medical University
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Sawaguchi Toshiko
Department Of Anatomy Keio University
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Nomura Mutsuko
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Namiki Mizuho
Dep. Of Emergency Medicine Tokyo Women's Medical Univ. Jpn
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Namiki Mizuho
Department Of Emergency Medicine Tokyo Women's Medical University
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Mori Tomohisa
Department Of Legal Medicine Tokyo Women's Medical University
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Narita Minoru
Department Of Emergency Medicine Tokyo Women's Medical University
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Narita Minoru
Department Of Anesthesiology Medical College Of Wisconsin
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Nomura Mutsuko
Department Of Emergency Medicine Tokyo Women's Medical University
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Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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