Evaluation of the Histamine H_1-Antagonist-Induced Place Preference in Rats
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概要
- 論文の詳細を見る
The place preferences by some histamine H1 antagonists, such as tripelennamine, optical isomers of chlorpheniramine (dl-, d- and l-forms) and pyrilamine, in rats were evaluated with the conditioned place preference paradigm. In the present study, tripelennamine and all of the optical isomers of chlorpheniramine, but not pyrilamine, produced a significant place preference. The degree of the place preference induced by optical isomers of chlorpheniramine (6.0 mg/kg) did not correlate with the H1-antagonistic potency of these drugs, suggesting that H1-antagonist-induced place preferences are not mediated by H1-receptor blockade. The tripelennamine (3.0 mg/kg)- and dl-chlorpheniramine (6.0 mg/kg)-induced place preferences were completely abolished by pretreatment with the dopamine D1-receptor antagonist SCH23390 (0.05 mg/kg). Furthermore, the doses of H1 antagonists that induced a place preference significantly reduced the levels of DOPAC, which may be mediated by inhibition of dopamine uptake, in the limbic forebrain (including the nucleus accumbens and olfactory tubercle). These results suggest that some H1 antagonists induce rewarding effects, which may be mediated by the activation of dopamine D1 receptors, followed by the inhibition of dopamine uptake.
- 社団法人 日本薬理学会の論文
- 1999-12-01
著者
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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SUZUKI Tsutomu
Department of Applied and Environmental Chemistry, Kitami Institute of Technology
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ONODERA Kenji
Department of Pharmacology, Tohoku University School of Dentistry
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Sawaguchi T
Department Of Emergency Medicine Tokyo Women's Medical University
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Mori Tetsuya
Department Of Radiology And Nuclear Medicine Hyogo Brain And Heart Center
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Onodera K
Department Of Dental Pharmacology Okayama University Graduate School Of Medicine And Dentistry
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Onodera Kenji
Department Of Dental Pharmacology
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MORI Tomohisa
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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NOMURA Mutsuko
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
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Suzuki Tsutomu
Department Of Emergency Medicine Tokyo Women's Medical University
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Mori T
First Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Mori T
Department Of Pharmacology School Of Pharmacy Hoshi University
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Nomura Mutsuko
Department Of Toxicology Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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TSUJI Minoru
Department of Pharmacology, School of Pharmacy, Hoshi University
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Tsuji Minoru
Department Of Pharmacology School Of Pharmacy Hoshi University
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Namiki Mizuho
Dep. Of Emergency Medicine Tokyo Women's Medical Univ. Jpn
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Namiki Mizuho
Department Of Emergency Medicine Tokyo Women's Medical University
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Mori Tomohisa
Department Of Legal Medicine Tokyo Women's Medical University
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Nomura Mutsuko
Department Of Emergency Medicine Tokyo Women's Medical University
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Suzuki Tsutomu
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Tsuji Minoru
Department of Pharmacology and Intractable Diseases Research Center (Division of Drug Research and Development),Tokyo Medical University
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ONODERA Kenji
Department of Chemical Pharmacology, Tohoku College of Pharmacy
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