HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
スポンサーリンク
概要
- 論文の詳細を見る
Participation of histamine H_1-and H_2-receptors in the bronchial musculature and vasculature of the dog was investigated by using the method for evaluating airway responses. A peristaltic pump and a Starling pneumatic resistance were used for a constant pressure perfusion. Dogs given 0.1-10μg histamine by a close intraarterial injection showed increases in ventilation overflow (bronchoconstriction) and in blood flow (bronchial vasodilatation) in a dose-dependent manner. The bronchoconstriction produced by histamine was antagonized strongly by chlorpheniramine, a H_1-receptor antagonist, but not modified by cimetidine, a H_2-receptor antagonist. The bronchial vasodilatation produced by histamine was antagonized by both chlorpheniramine and cimetidine. These results suggest that histamine evokes bronchoconstriction through H_1-receptors and bronchial vasodilatation through H_1-and H_2-receptors.
- 公益社団法人日本薬学会の論文
著者
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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YANAURA Saizo
Department of Pharmacology, School of Pharmacy, Hoshi University
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GOTO Kazuhiro
Department of Materials Science, Faculty of Science, Kanagawa University
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HOSOKAWA Tomokazu
Department of Pharmacology, School of Pharmacy, Hoshi University
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Hosokawa Tomokazu
Department Of Pharmacology Hoshi College Of Pharmacy
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Misawa Miwa
Department Of Pharmacology Hoshi College Of Pharmacy
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Yanaura Saizo
Department Of Pharmacology Hoshi College Of Pharmacy
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Yanaura Saizo
Department Of Applied Pharmacology School Of Pharmacy Hoshi University
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Goto Kazuhiro
Department Of Electronic Engineering Tokyo Denki University
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Goto Kazuhiro
Department Of Pharmacology Hoshi College Of Pharmacy
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Hukuhara T
Jikei Univ. School Of Medicine Tokyo
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Hosokawa Tomokazu
Department of Medicinal Plant Science, Hoshi University
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YANAURA Saizo
Department of Applied Pharmacology, School of Pharmacy, Hoshi University:Research Institute of Nippon Chemiphar, Co., Ltd.
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