HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG

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概要

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• Participation of histamine H_1-and H_2-receptors in the bronchial musculature and vasculature of the dog was investigated by using the method for evaluating airway responses. A peristaltic pump and a Starling pneumatic resistance were used for a constant pressure perfusion. Dogs given 0.1-10μg histamine by a close intraarterial injection showed increases in ventilation overflow (bronchoconstriction) and in blood flow (bronchial vasodilatation) in a dose-dependent manner. The bronchoconstriction produced by histamine was antagonized strongly by chlorpheniramine, a H_1-receptor antagonist, but not modified by cimetidine, a H_2-receptor antagonist. The bronchial vasodilatation produced by histamine was antagonized by both chlorpheniramine and cimetidine. These results suggest that histamine evokes bronchoconstriction through H_1-receptors and bronchial vasodilatation through H_1-and H_2-receptors.

• 公益社団法人日本薬学会の論文

著者

• MISAWA Miwa

  Department of Pharmacology, School of Pharmacy, Hoshi University

• YANAURA Saizo

  Department of Pharmacology, School of Pharmacy, Hoshi University

• GOTO Kazuhiro

  Department of Materials Science, Faculty of Science, Kanagawa University

• HOSOKAWA Tomokazu

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Hosokawa Tomokazu

  Department Of Pharmacology Hoshi College Of Pharmacy

• Misawa Miwa

  Department Of Applied Pharmacology Hoshi University

• Misawa Miwa

  Department Of Pharmacology Hoshi College Of Pharmacy

• Yanaura Saizo

  Department Of Pharmacology Hoshi College Of Pharmacy

• Yanaura Saizo

  Department Of Applied Pharmacology School Of Pharmacy Hoshi University

• Goto Kazuhiro

  Department Of Electronic Engineering Tokyo Denki University

• Goto Kazuhiro

  Department Of Pharmacology Hoshi College Of Pharmacy

• Hukuhara T

  Jikei Univ. School Of Medicine Tokyo

• Hosokawa Tomokazu

  Department of Medicinal Plant Science, Hoshi University

• YANAURA Saizo

  Department of Applied Pharmacology, School of Pharmacy, Hoshi University:Research Institute of Nippon Chemiphar, Co., Ltd.

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