Increase in the Expression of Matrix Metalloproteinase-12 in the Airways of Rats with Allergic Bronchial Asthma(Pharmacology)
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概要
- 論文の詳細を見る
Although an involvement of matrix metalloproteinase (MMP)-12 in the development of chronic obstructive pulmonary disease (COPD) and airway inflammation has been suggested, its detailed role in the airways is not well known now. In the present study, the changes in the expression and localization of MMP-12 in airways of repeatedly antigen-challenged rats were investigated to show an association of MMP-12 with allergic bronchial asthma. Rats sensitized by dinitrophenylated Ascaris antigen were 3 times repeatedly challenged with aerosolized antigen solution to induce an asthmatic reaction. Twenty-four hours after the last antigen challenge, marked airway inflammation and bronchial smooth muscle hyperresponsiveness were observed. In this animal model of allergic bronchial asthma, a significant increase in the expression/activity of MMP-12 was found: the peak was observed at 12h after the last antigen challenge. Furthermore, mRNA expression of MMP-12 was also increased at the early phase (1-3h) after the last antigen challenge. Immunohistochemical studies revealed that MMP-12 was mainly expressed in airway epithelia and alveolar macrophages. These findings suggest that MMP-12 is upregulated after the induction of asthmatic reaction. MMP-12 might be a new target for the therapy against allergic bronchial asthma.
- 公益社団法人日本薬学会の論文
- 2007-02-01
著者
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CHIBA Yoshihiko
Department of Pharmacology, School of Pharmacy, Hoshi University
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MISAWA Miwa
Department of Pharmacology, School of Pharmacy, Hoshi University
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SAKAI Hiroyasu
Department of Internal Medicine, Gifu University Graduate School of Medicine
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千葉 喜彦
山口大学理学部時間生物学研究室
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Chiba Yoshihiko
Dep. Of Pharmacology School Of Pharmacy Hoshi Univ.
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YU Yingyan
Department of Pathology, Shanghai First People's hosppital
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Yu Yingyan
Department Of Pathology Shanghai First People's Hosppital
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Misawa Miwa
Department Of Pharmacology School Of Pharmacy Hoshi University
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Misawa M
Hoshi Univ. Tokyo Jpn
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Misawa Miwa
Department Of Applied Pharmacology Hoshi University
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Sakai Hiroyasu
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sakai H
Department Of Pharmaceutical Physiology Graduate School Of Medicine And Pharmaceutical Sciences Univ
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Yu Yingyan
Department Of Pharmacology School Of Pharmacy Hoshi University
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Sugitani Hideki
Department Of Clinical Chemistry Hoshi University School Of Pharmacy And Pharmaceutical Sciences
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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