Effect of sugammadex on bronchial smooth muscle function in rats
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概要
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Sugammadex can encapsulate the steroid-based neuromuscular blocker molecule and results in rapid reversal of neuromuscular blockade induced by rocuronium and vecuronium. However, several cases of bronchospasm after the administration of sugammadex have been reported. The current study was carried out to determine whether sugammadex directly affects smooth muscle function of the airways. The ring strips of left main bronchi were isolated from male Wistar rats and isometric forces were measured. In the isolated bronchial smooth muscle tissues, sugammadex (10–8 – 10 –3 M) had no effect on baseline tension or the acetylcholine (ACh; 30 μM)-induced sustained contraction. Moreover, sugammadex did not affect bronchial smooth muscle responsiveness to ACh. These findings indicate that sugammadex itself does not affect contractile function in bronchial smooth muscle of the rat.
- 2012-06-01
著者
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花崎 元彦
岡山大学大学院医歯薬学総合研究科麻酔科蘇生科
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花崎 元彦
岡山大学医学部附属病院 麻酔蘇生
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花崎 元彦
岡山大学 大学院医歯学総合研究科消化器･腫瘍外科学部門
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Nakatsuka Hideki
Department Of Anesthesiology And Resuscitology Okayama University Graduate School Of Medical Dentist
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Chiba Yoshihiko
Department Of Pharmacology School Of Pharmacy Hoshi University
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Hanazaki Motohiko
Department Of Anesthesiology And Resuscitology Okayama University Graduate School Of Medical Dentist
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Hanazaki Motohiko
Department Of Anesthesiology And Resuscitology Okayama University Medical School
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Yoshioka Naoki
Department Of Anesthesiology And Icm Kawasaki Medical School
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Fujita Yoshihisa
Department Of Anesthesiology & Intensive Care Medicine Kawasaki Medical School
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Katayama Hiroshi
Department Of Anesthesiology And Resuscitology Okayama University Graduate School Of Medical Dentist
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Chiba Yoshihiko
Department Of Biology School Of Pharmacy Hoshi University
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Katayama Hiroshi
Department Of Anesthesiology And Intensive Care Medicine Kawasaki Medical School
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Nakatsuka Hideki
Department Of Anesthesiology And Intensive Care Medicine Kawasaki Medical School
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Hanazaki Motohiko
Department Of Anesthesiology And Intensive Care Medicine Kawasaki Medical School
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Yoshioka Naoki
Department Of Anesthesiology And Intensive Care Medicine Kawasaki Medical School
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