16α HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES
スポンサーリンク
概要
- 論文の詳細を見る
Adrenal and liver tissues from a human fetus aborted after 6 months gestation were sliced to 30μ thickness and incubated with dehydroepiandrosterone-4-<SUP>14</SUP>C in Krebs-Ringer bicarbonate buffer solution. 16αOH DHEA was found in the adrenal incubate after purification by alumina column chromatography, acetylation, thin layer chromatography and recrystallization to constant specific activity. The recrystallization data indicated that 4.9% of the radioactive material in the initial extract was 16αOH DHEA. However, the radioactive material in the androstenetriol fraction of the initial extract was not associated with carrier androstenetriol. Androstenetriol was detected in the liver incubate after purification by alumina column chromatography, two successive thin layer chromatographies and recrystallization to constant specific activity. The recrystallization data showed that 5.6% of the radioactive material in the initial extract was androstenetriol. But the radioactive material in the 16αOH DHEA fraction of the initial extract was dissociated from carrier 16αOH DHEA. The possible role of the fetus in the formation of estriol during pregnancy is discussed.
- 社団法人 日本内分泌学会の論文
著者
-
SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
-
Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
-
Nakayama Tetsuya
Department Of Obstetrics And Gynecology School Of Medicine Showa University
-
Fujita Yoshihisa
Department of Chemistry, Biology and Marine Science, University of the Ryukyus
-
Arai Kiyoshi
Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo
-
NAGATOMI KEIJI
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
-
Fujita Yoshihisa
Department Of Anesthesiology & Intensive Care Medicine Kawasaki Medical School
-
Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
-
SATOH KAZUO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
関連論文
- BIOSYNTHESIS OF STEROIDS BY HUMAN FETAL ADRENAL PERFUSED IN VITRO
- Anomalous Phase Sequence in Binary Mixture of 3MC2PCPOPB and TFMHPOBC ( FERROELECTRIC MATERIALS AND THEIR APPLICATIONS)
- Effects of fadrozole and leuprorelin acetate on aromatase activity and cell proliferation in a human breast cancer cell line (SK-BR-3)
- Inhibitory Effects of Catecholamines and Maternal Stress on Aromatase Activity in the Fetal Rat Brain
- Aromatase and Estrogen 2-Hydroxylase Activities of Human Placental Microsomes in Pregnancy-Induced Hypertension
- Localization of Serum Proteins in the Embryo
- SETTLEMENT OF COMATULID LARVAE ON THE CORAL REEFS OF THE RYUKYU ISLANDS(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Urinary Excretion of D-Serine in Human : Comparison of Different Ages and Species
- Effects of sintered apatite on bone regeneration in rabbits
- EFFECTS OF ESTRIOL VAGINAL TABLETS ON THE EPITHELIUM OF THE PORTIO VAGINALIS
- The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells
- The Effect of Vaginal Delivery on the Pelvic Floor
- Changes in Purine Metabolism and Production of Oxygen Free Radicals by Intermittent Partial Umbilical Cord Occlusion in Chronically Instrumented Fetal Lambs
- PTHrP and PTH/PTHrP Receptor Expressions in Human Endometrium
- The Role of Parathyroid Hormone-Related Protein in Intra-Tracheal Fluid
- The Effect of Cytokines on Parathyroid Hormone-Related Protein (PTH-rP) Production in Human Amnion Cells
- New record of a crinoid symbiotic crab, Harrovia longipes Lanchester, 1900 (Decapoda: Brachyura: Pilumnidae: Eumedoninae) from Japan
- Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility : results
- Recombinant follicle-stimulating hormone (follitropin alfa) for ovulation induction in Japanese patients with anti-estrogen-ineffective oligo- or anovulatory infertility : results of a phase II dose-response study
- Larval development of Galathea amboinensis (Decapoda: Anomura: Galatheidae) under laboratory conditions.
- Redescription of the first zoeas of six Macrobrachium species (Decapoda: Caridea: Palaemonidae) occurring in Japan
- Larval stages of Macrobrachium australe (Guerin Meneville, 1838) (Decapoda: Palaemonidae), described from laboratory-reared material
- Larval development of Galathea inflata Potts, 1915 (Decapoda: Anomura: Galatheidae) described from laboratory-reared material
- 3β-Hydroxysteroid Dehydrogenase Activity in Human Osteoblast-Like Cells
- A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
- Optically Detected Cyclotron Resonance in CdTe
- Prostaglandin F2α Metabofites in Plasma and Urine in Relation to Peripheral Plasma Levels of Progesterone and Estradiof-17β in the Rat During Pregnancy and Parturition
- Treatment of a Crown Malformation in a Lower Left Permanent Central Incisor Tooth Derived from Earlier Traumatic Injuries to a Primary Tooth Based on Diagnosis using 3DX^(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayam
- THE EFFECT OF AN ACUTE STRESS IN LATE PREGNANCY ON HYPOTHALAMIC CATECHOLAMINES OF THE RAT FETUS
- Improvement of Preservation Method for Ammonia-Oxidizing Bacteria by Freeze-Drying(Soil Biology)
- Two Kinds of Ammonia-Oxidizing Bacteria Isolated from Biologically Deodorizing Plants in Cold District(ENVIRONMENTAL BIOTECHNOLOGY)
- Coronary Artery Spasm Induced by Injection of an Atropine-neostigmine Mixture A Case Report
- Application of Forward Dispersion Relation to Kaon Carbon Scattering
- Do radial arterial pressure curves have diagnostic validity for identify severe aortic stenosis?
- PATHWAY OF THE FORMATION OF ESTRIOL IN THE FETOPLACENTAL UNIT
- FORMATION OF ESTROGENS IN THE FETO-PLACENTAL COMPARTMENTS
- 16α HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES
- BIOGENESIS OF ESTROGENS BY THE PERFUSED HUMAN OVARY (I) CONVERSION OF PROGESTERONE-14C AND ANDROST-4-ENE-3, 17-DIONE-14C TO ESTRADIOL-17β
- BIOSYNTHESIS OF ESTROGENS IN IN VITRO PERFUSION OF THE HUMAN PLACENTA
- THE FORMATION OF ESTRIOL FROM ESTRADIOL-17β BY THE HUMAN FETAL ADRENAL TISSUE
- BIO-AND HISTOCHEMICAL STUDIES ON ENZYMES IN STEROIDOGENESIS IN THE ADRENAL CORTEX OF MATURING RATS
- The Possibility of Clinical Application of the Thromboxane A_2 Synthase Inhibitor, Ozagrel, for the Treatment and Prevention of Preeclampsia : A Preliminary Report
- Peritoneal and Peripheral B-1-Cell Populations in Patients with Endometriosis
- Stainability of steroid hormones in tissue using different fixatives
- Prostaglandin F2α and E1 in Plasma and Amniotic Fluid During Human Pregnancy and Labor
- Biosynthesis of Prostaglandin in Human Decidua, Amnion, Chorion and Villi
- Metabolic Fate of 3H-Testosterone Administered into the Fetoplacental Compartments
- The Effect of Ovarian Steroid Feedback upon Radioimmunoreactive Luteinizing Hormone Releasing Hormone in the Hypothalamus
- Sensitization to Bjerkandera adusta Enhances Severity of Cough Symptom in Patients with Fungus-Associated Chronic Cough(FACC)
- Refractory Hypotension During Propofol/Fentanyl Anesthesia. A Report of Two Cases
- Possibility of application of calcium carbonate in pulpotomy of rat molars
- Two galatheid associates of crinoids from the Ryukyu Islands (Decapoda: Anomura: Galatheidae), with their ecological notes
- Zoeal Development of Two Spot-Pattern Morphs of Neopetrolisthes maculatus, and of N. spinatus (Crustacea : Decapoda : Anomura : Porcellanidae), Reared under Laboratory Conditions
- A Radioimmunoassay of Serum 16α-Hydroxypregnenolone With Specific Antiserum
- Safety and efficacy of oral rehydration therapy until 2h before surgery : a multicenter randomized controlled trial
- The formaldehyde inspiration by the child patient, dentist, and dental assistant during formocresol pulpotomy
- Effect of sugammadex on bronchial smooth muscle function in rats
- Biosynthetic pathways for corticoids and androgen formation in human fetal adrenal tissue in vitro.
- Inhibition of fetal adrenal 21-hydroxylase by naturally occurring steroids.
- Optically Detected Cyclotron Resonance in CdTe
- A study of 5.ALPHA.-reductase in human fetal brain.
- Cytokine Production by Peripheral Blood Mononuclear Cells and Metabolic Turnover of Bone During Pregnancy.