Prostaglandin F<SUB>2α</SUB> and E<SUB>1</SUB> in Plasma and Amniotic Fluid During Human Pregnancy and Labor
スポンサーリンク
概要
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In order to elucidate the significance of PGs in human labor, PGE<SUB>1</SUB> and F<SUB>2α</SUB> in biological fluid during human pregnancy and labor were measured by RIA newly developed.<BR>Analytical studies demonstrated that the levels of PGF<SUB>2α</SUB> in maternal plasma were 3.7±2.5ng/ml a few days before parturition, 2.0±0.9ng/m<I>l</I> in the first stage of labor and 1.9±1.4ng/m<I>l</I> at delivery. Thus the concentrations of PGF in maternal plasma showed no significant changes around parturition. On the other hand, the level of PGF<SUB>2α</SUB>. in amniotic fluid represented a significant increase up to 44.27±32.81ng/m<I>l</I> at delivery from 1.45±0.76ng/m<I>l</I> before labor at 38-40 weeks of pregnancy (p<0.05), although it was uncertain whether this elevation was the cause or effect of uterine contraction.<BR>The concentration of PGE<SUB>1</SUB> ranged from 2 to 14ng/m<I>l</I> around parturition. This indicates that there was little remarkable difference between the levels of PGE<SUB>1</SUB> in plasma and amniotic fluid during the last month of pregnancy and labor.<BR>Possible involvement of prostaglandins (PGs) in human labor has been discussed.
- 社団法人 日本内分泌学会の論文
著者
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SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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Kinoshita Katsuyuki
Department Of Obstetrics And Gynecology Juntendo University
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Sakamoto Shoichi
Department Of Applied Physics Seikei University
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Kinoshita Katsuyuki
Department Of Mechanical Engineering Faculty Of Engineering Yamaguchi University
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Sakamoto Shoichi
Department Applied Physics Seikei University
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SAKAMOTO SHOICHI
Department of Obstetrics and Gynecology, University of Tokyo, Faculty of Medicine
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