THE FORMATION OF ESTRIOL FROM ESTRADIOL-17β BY THE HUMAN FETAL ADRENAL TISSUE
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概要
- 論文の詳細を見る
Human adrenal tissue from a fetus aborted after 6 months gestation was sliced to 30μ thickness and incubated with estradiol-17β-16-<SUP>14</SUP>C in Krebs-Ringer bicarbonate buffer solution. The estriol fraction from the incubation mixture was purified by gradient elution partition chromatography on a Celite column, paper chromatography and thin layer chromatography to constant specific activity. Throughout these purification steps, the radioactive metabolite in the estriol fraction behaved exactly as the added carrier standard estriol. It was, therefore, considered that estradiol-17β-16-<SUP>14</SUP>C was converted to estriol by the incubation experiment with the fetal adrenal tissue. The overall conversion rate was 1.1%. In addition, the possible role of a fetus in the formation of estriol during pregnancy was discussed.
- 社団法人 日本内分泌学会の論文
著者
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SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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NAKAYAMA T.
Department of Food Science, Univeristy of Georgia
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Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Nakayama Tetsuya
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Arai Kiyoshi
Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo
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NAGATOMI KEIJI
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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TABEI TORU
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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SATOH KAZUO
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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YANAIHARA TAKUMI
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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TABEI TORU
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo
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