Biosynthesis of Prostaglandin in Human Decidua, Amnion, Chorion and Villi
スポンサーリンク
概要
- 論文の詳細を見る
The biosynthetic study utilizing <SUP>14</SUP>C-eicosatrienoic acid or <SUP>14</SUP>C-arachidonic acid as substrate was carried out with human fetal membranes and villi at term pregnancy. Prostaglandin synthetase activity was demonstrated in the homogenates of decidua, chorionic membrane, amniotic membrane and villi. The enzyme was localized in the microsomal fractions of decidua and amniotic membrane, of which relative activities were 5.1% and 3.1% to that of bovine seminal vesicle microsome, respectively. To achieve the maximal enzyme activity, GSH, Hb and 1-epinephrine must be present. The only type of prostaglandins found in our assay was only Ecompounds, which seemed to be due mainly to the cofactors employed. Production of PGE<SUB>2</SUB> in the microsomal fraction of either decidua or bovine seminal vesicle was inhibited by the 80, 000 × <I>g</I> supernatant fraction of decidua, which was shown to contain an inhibitory substance of heat-unstable and non-dialyzable nature. The significance of the experimental results in assessing the control of PG production in human decidua is discussed.
- 社団法人 日本内分泌学会の論文
著者
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SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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Kinoshita Katsuyuki
Department Of Obstetrics And Gynecology Juntendo University
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Sakamoto Shoichi
Department Of Applied Physics Seikei University
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Kinoshita Katsuyuki
Department Of Mechanical Engineering Faculty Of Engineering Yamaguchi University
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Sakamoto Shoichi
Department Applied Physics Seikei University
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