LOCALIZATION OF HUMAN CHORIONIC GONADOTROPIN AT THE NIDATORY SITE OF TUBAL PREGNANCY

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Localization of human chorionic gonadotropin (HCG) at the nidatroy sites of tubal pregnancies was studied using immunoperoxidase and immunofluorescent methods. In the villous trophoblast including anchoring villi, HCG was exclusively located in the syncytiotrophoblast. The amount of HCG which syncytiotrophoblast contained decreased in relation to the degenerative changes of the placental villi. In the anchoring villi, HCG was shown to exist more at the proximal part of the syncytiotrophoblast than at the distal part of the same villi. A markedly strong immunoreaction was observed at the syncytiotrophoblast which was scattered in the trophoblastic shell and also partly covered the trophoblastic shell. Not only the mononuclear trophoblast with abundunt glycogen in the cytoplasm, which usually existed in the trophoblastic column and shell and was classified as transitional trophoblast based on ultrastructural features, but also the mononuclear trophoblast that existed in the fibrinoid layer showed a weak but not negligible immune reaction. The characteristic localization of HCG at the nidatory site of the tubal pregnancy seemed to imply some special roles of HCG on nidation and various phenomena correlated with it. And it was also shown from these findings that the transitional trophoblast contained a small amount of HCG and that HCG concentration of the villous syncytiotrophoblast reflected the degenerative changes of the villi.
日本組織細胞化学会の論文

LOCALIZATION OF HUMAN CHORIONIC GONADOTROPIN AT THE NIDATORY SITE OF TUBAL PREGNANCY

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