Hypothalamic-Pituitary Testicular Interrelations in Fetal Rats : Effects of Castration on <SUP>3</SUP>H-Leucine Uptake in Pituitary Basophilic Cells
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概要
- 論文の詳細を見る
Male fetal rats were castrated <I>in utero</I> on the 21st day of gestation. Twenty-four hrs after the operation, they were given a subcutaneous injection of 22.5μCi of <SUP>3</SUP>H-leucine. One hr later they were autopsied, and their pituitaries were examined autoradiographica lly by the dipping method. Our experiment showed a significant increase in both leucine uptake and percentage of basophilic cells after the castration. Since the parallel relationship between the uptake of leucine and the biosynthesis of anterior pituitary hormones have been recently elucidated, the significant enhancement of leucine uptake by basophilic cells suggests the increase in production of gonadotrophic hormones by these cells. The increase in percentage of basophilic cells also supports the view of the existence of feedback mechanism between the testis and the hypothalamic-pituitary axis in the fetal rat.
- 社団法人 日本内分泌学会の論文
著者
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Nakai Toshiaki
Department Of Clinical Pathology University Of Tsukuba
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Sakamoto Shoichi
Department Of Applied Physics Seikei University
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KIGAWA Tomonori
Department of Obstetrics and Gynecology, Oita Medical College
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Kigawa Tomonori
Department Of Obstetrics And Gynecology Faculty Of Medicine University Of Tokyo Tokyo
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Sakamoto Shoichi
Department Applied Physics Seikei University
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